Isonipecotamide

Product Name: Isonipecotamide
CAS No.: 39546-32-2
Chemical Name: Isonipecotamide
Synonyms: PIPERIDINE-4-CARBALDEHYDE;PIPERIDINE-4-CARBOXAMIDE;ISONIPECOTAMIDE;4-PIPERIDINECARBOXAMIDE;Isonipectoamide;Isonepicotamide;Isonipecotinamide;Isonipecotamide>TIMTEC-BB SBB004237;Isonipecotamide,98%
CBNumber: CB3411759
Molecular Formula: C6H12N2O
Formula Weight: 128.17
MOL File: 39546-32-2.mol

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Isonipecotamide Property

Melting point:: 145-148 °C(lit.)
Boiling point:: 237.61°C (rough estimate)
Density: 1.0754 (rough estimate)
refractive index: 1.4880 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Crystalline Powder
pka: 16.48±0.20(Predicted)
color: White to light yellow
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
BRN: 112554
Stability:: Hygroscopic
InChIKey: DPBWFNDFMCCGGJ-UHFFFAOYSA-N
LogP: -0.88
CAS DataBase Reference: 39546-32-2(CAS DataBase Reference)
EPA Substance Registry System: 4-Piperidinecarboxamide (39546-32-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I17907
Product name: 4-Piperidinecarboxamide
Purity: 97%
Packaging: 25g
Price: $46
Updated: 2024/03/01

Sigma-Aldrich

Product number: I17907
Product name: 4-Piperidinecarboxamide
Purity: 97%
Packaging: 100g
Price: $145
Updated: 2024/03/01

TCI Chemical

Product number: I0255
Product name: Isonipecotamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $70
Updated: 2024/03/01

TCI Chemical

Product number: I0255
Product name: Isonipecotamide
Purity: >98.0%(GC)
Packaging: 250g
Price: $377
Updated: 2024/03/01

Alfa Aesar

Product number: A13442
Product name: Isonipecotamide, 98%
Packaging: 10g
Price: $20.65
Updated: 2024/03/01

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Isonipecotamide Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

Reactant for synthesis of:• ;Survival motor neuron (SMN) protein modulators1• ;Diaminotriazine hNav1.7 inhibitors2• ;Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase3• ;Orally available naphthyridine protein kinase D inhibitors4• ;Phosphodiesterase 5 inhibitors5Reactant for identification of small molecular inhibitors of importin-β mediated nublear import6

Uses

Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.

Uses

Anesthetic, analgesic, antimicrobial and cooling agent for prevention or treatment of skin irritation.

Application

Isonipecotamide is an important substrate for organic synthesis reactions and can be used to prepare a wide range of inhibitors:
(1) Dual inhibitors of thrombin and cholinesterase with therapeutic potential for Alzheimer's disease^[1].
(2) 5-HT receptor inhibitors, based on Isonipecotamide synthesised piperidine carboxamide derivatives showing signs of decreasing 5-HT levels alone while increasing dopamine levels, with antidepressant drug effects^[2].
(3) Reversible inhibitors of coagulation factor Xa (fXa) and thrombin (thr) (cmpds 1-3), which have the ability to impede the infection of VERO cells with SARS-CoV-2, with cmpds3 showing a significant inhibitory effect on SARS-CoV-2 infection (~30%) at lower concentrations (3-50 μM)^[3].

Definition

ChEBI: 4-Piperidine carboxamide is a piperidinecarboxamide.

References

[1] ROSA PURGATORIO. First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.[J]. Molecules, 2021. DOI:10.3390/molecules26175208.
[2] SHAMIM AKHTAR. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.[J]. Pakistan journal of pharmaceutical sciences, 2012.
[3] FLAVIO DE MAIO. Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection.[J]. Viruses-Basel, 2022. DOI:10.3390/v14081730.

Isonipecotamide Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 4-Amino-1-benzylpiperidine TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE 1-METHYL-PIPERIDINE-4-CARBONITRILE (1-Methyl-4-piperidinyl)methanamine 1-Boc-4-cyanopiperidine

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Isonipecotamide Suppliers

Americas 1 Belgium 4 Canada 3 China 253 Europe 3 France 2 Germany 6 India 29 Japan 7 Singapore 1 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 12 United States 54 Venezuela 1 Global 382

Shanghai Hobor Chemical Co., Ltd

Tel: 21-21-61026752 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 409
Advantage: 60

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 15523000485
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1686
Advantage: 58

Terma Medicare India Pvt Ltd

Tel: 021-52530655 18930806002
Email: yuli@semsstar.com
Country: China
ProdList: 134
Advantage: 58

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375878 15269101859
Email: 3385307203@qq.com
Country: China
ProdList: 294
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3576
Advantage: 66

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

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View Lastest Price from Isonipecotamide manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Hexahydroisonicotinamide 39546-32-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100tons
Release date: 2023-09-21

Hebei Kingfiner Technology Development Co. , Ltd.

Product: Piperidine-4-carboxamide 39546-32-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000kg
Release date: 2023-12-08

Anhui Zhongda Biotechnology Co., Ltd

Product: Hexahydroisonicotinamide 39546-32-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-10-23

39546-32-2, IsonipecotamideRelated Search:

piperidine-N-carbaldehyde,PIPERIDINE-1-CARBALDEHYDE,N-FORMYL PIPERIDINE PIPERIDINE-1-CARBALDEHYDE 4-Benzyloxycarbonylaminopiperidine Hydrochloride DL-Pipecolinic acid Piperazine-2-carboxylic acid dihydrochloride 3-CBZ-AMINOPIPERIDINE HCL tert-Butyl 1-piperazinecarboxylate PIPERIDIN-3-ONE HYDROCHLORIDE Azido-PEG1-CH2CO2H 4-HYDROXY-3-METHYLBENZOIC ACID Benzyl 4-hydroxy-1-piperidinecarboxylate 4-Pyrimidinecarboxylic acid Isonipecotic acid 4,4-Piperidinediol hydrochloride PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Methyl 4-piperidinecarboxylate 4-Piperidinemethanol Methyl isonipecotate

Piperidine-4-carboxylic acid aMide

IsonipecotaMide, 98% 100GR

Isonipecotamide, 4-Carbamoylpiperidine, 4-(Aminocarbonyl)piperidine

4 - piperidine forMaMide

4-Piperidinecarboxamide 97%

Hexahydroisonicotimide

HEXAHYDROISONICOTINAMIDE

LABOTEST-BB LT00848032

ISONIPECOTAMIDE

PIPERIDINE-4-CARBOXAMIDE

TIMTEC-BB SBB004237

4-PIPERIDINECARBOXAMIDE

Isonipecotinamide

Isonipecotamide,98%

4-Piperazine-D9-carboxamide

Isonipectoamide

PIPERIDINE-4-CARBALDEHYDE

Hexahydroisonicotinamide, Isonipecotamide

4-Piperidinecarboxamide ,98%

Piperidine-4-carboxamide 98%

China HEXAHYDROISONICOTINAMIDE

Isonipecotamide&gt

Piperidine-4-carboxylamide

4-Piperidinecarboxamide (9CI, ACI)

Isonipecotamide /4-Piperidinecarboxamide

Raffenacin impurity 42 (zopiclone impurity 7) (piperidine-4-carboxamide)

Piperdine-4-carboxamide

Piperidine-4-formamide

Revefenacin Impurity 40

Isonepicotamide

lsonipecotamide /4-Piperidinecarboxamide

4-piperdinecarboxamide

39546-32-2

AMINE

Piperidines

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C5 to C7

Chemical Synthesis

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