Isonipecotamide
- Product Name
- Isonipecotamide
- CAS No.
- 39546-32-2
- Chemical Name
- Isonipecotamide
- Synonyms
- PIPERIDINE-4-CARBALDEHYDE;PIPERIDINE-4-CARBOXAMIDE;ISONIPECOTAMIDE;4-PIPERIDINECARBOXAMIDE;Isonipectoamide;Isonepicotamide;Isonipecotinamide;Isonipecotamide>TIMTEC-BB SBB004237;Isonipecotamide,98%
- CBNumber
- CB3411759
- Molecular Formula
- C6H12N2O
- Formula Weight
- 128.17
- MOL File
- 39546-32-2.mol
Isonipecotamide Property
- Melting point:
- 145-148 °C(lit.)
- Boiling point:
- 237.61°C (rough estimate)
- Density
- 1.0754 (rough estimate)
- refractive index
- 1.4880 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 16.48±0.20(Predicted)
- color
- White to light yellow
- Water Solubility
- Soluble in water.
- Sensitive
- Hygroscopic
- BRN
- 112554
- Stability:
- Hygroscopic
- InChIKey
- DPBWFNDFMCCGGJ-UHFFFAOYSA-N
- LogP
- -0.88
- CAS DataBase Reference
- 39546-32-2(CAS DataBase Reference)
- EPA Substance Registry System
- 4-Piperidinecarboxamide (39546-32-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I17907
- Product name
- 4-Piperidinecarboxamide
- Purity
- 97%
- Packaging
- 25g
- Price
- $46
- Updated
- 2024/03/01
- Product number
- I17907
- Product name
- 4-Piperidinecarboxamide
- Purity
- 97%
- Packaging
- 100g
- Price
- $145
- Updated
- 2024/03/01
- Product number
- I0255
- Product name
- Isonipecotamide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- I0255
- Product name
- Isonipecotamide
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $377
- Updated
- 2024/03/01
- Product number
- A13442
- Product name
- Isonipecotamide, 98%
- Packaging
- 10g
- Price
- $20.65
- Updated
- 2024/03/01
Isonipecotamide Chemical Properties,Usage,Production
Chemical Properties
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER
Uses
Reactant for synthesis of:• ;Survival motor neuron (SMN) protein modulators1• ;Diaminotriazine hNav1.7 inhibitors2• ;Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase3• ;Orally available naphthyridine protein kinase D inhibitors4• ;Phosphodiesterase 5 inhibitors5Reactant for identification of small molecular inhibitors of importin-β mediated nublear import6
Uses
Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.
Uses
Anesthetic, analgesic, antimicrobial and cooling agent for prevention or treatment of skin irritation.
Application
Isonipecotamide is an important substrate for organic synthesis reactions and can be used to prepare a wide range of inhibitors:
(1) Dual inhibitors of thrombin and cholinesterase with therapeutic potential for Alzheimer's disease[1].
(2) 5-HT receptor inhibitors, based on Isonipecotamide synthesised piperidine carboxamide derivatives showing signs of decreasing 5-HT levels alone while increasing dopamine levels, with antidepressant drug effects[2].
(3) Reversible inhibitors of coagulation factor Xa (fXa) and thrombin (thr) (cmpds 1-3), which have the ability to impede the infection of VERO cells with SARS-CoV-2, with cmpds3 showing a significant inhibitory effect on SARS-CoV-2 infection (~30%) at lower concentrations (3-50 μM)[3].
Definition
ChEBI: 4-Piperidine carboxamide is a piperidinecarboxamide.
References
[1] ROSA PURGATORIO. First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.[J]. Molecules, 2021. DOI:10.3390/molecules26175208.
[2] SHAMIM AKHTAR. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.[J]. Pakistan journal of pharmaceutical sciences, 2012.
[3] FLAVIO DE MAIO. Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection.[J]. Viruses-Basel, 2022. DOI:10.3390/v14081730.
Isonipecotamide Preparation Products And Raw materials
Raw materials
Preparation Products
Isonipecotamide Suppliers
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- 03-36680489
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View Lastest Price from Isonipecotamide manufacturers
- Product
- Hexahydroisonicotinamide 39546-32-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KG
- Release date
- 2024-11-09
- Product
- Hexahydroisonicotinamide 39546-32-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100tons
- Release date
- 2023-09-21
- Product
- Piperidine-4-carboxamide 39546-32-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2024-06-11