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4-Piperidinemethanol

Product Name
4-Piperidinemethanol
CAS No.
6457-49-4
Chemical Name
4-Piperidinemethanol
Synonyms
PIPERIDIN-4-YLMETHANOL;piperidin-4-ylmethanol hydrochloride;PiperidineMethanol;4-PIPERIDYLMETHANOL;4-(HYDROXYMETHYL)PIPERIDINE;55-59℃;BUTTPARK 27\08-74;4-piperdinemethanol;4-PIPERIDINEMETHANOL;4-Piperidinecarbinol
CBNumber
CB5710894
Molecular Formula
C6H13NO
Formula Weight
115.17
MOL File
6457-49-4.mol
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4-Piperidinemethanol Property

Melting point:
55-59 °C(lit.)
Boiling point:
118-120 °C10 mm Hg(lit.)
Density 
0,997 g/cm3
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Water Solubility 
Soluble in water
form 
Crystalline Powder, Chunks and/or Solid
pka
14.94±0.10(Predicted)
color 
White to off-white
Sensitive 
Hygroscopic
BRN 
103071
InChI
InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2
InChIKey
XBXHCBLBYQEYTI-UHFFFAOYSA-N
SMILES
N1CCC(CO)CC1
CAS DataBase Reference
6457-49-4(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-22
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
Hazard Note 
Irritant/Hygroscopic
HazardClass 
8
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
497312
Product name
4-Piperidinemethanol
Purity
97%
Packaging
5g
Price
$203
Updated
2025/07/31
Sigma-Aldrich
Product number
497312
Product name
4-Piperidinemethanol
Purity
97%
Packaging
25g
Price
$995
Updated
2025/07/31
TCI Chemical
Product number
P1653
Product name
4-Piperidinemethanol
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
P1653
Product name
4-Piperidinemethanol
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$239
Updated
2025/07/31
TRC
Product number
P481945
Product name
4-Piperidinemethanol
Packaging
10g
Price
$385
Updated
2021/12/16
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4-Piperidinemethanol Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder, chunks

Uses

4-Piperidinemethanol may be used in the preparation of:

  • N-tert-butoxycarbonyl-4-hydroxymethyl piperidine
  • desferrioxamine B (DFO) containing third generation triazine dendrimer
  • ethyl 3-(4-(hydroxymethyl)piperidin-1-yl)propanoate (EHMPP)
  • 4-(hydroxymethyl)piperidine-1-carbodithioic acid (HL)
  • 1-[[(1E)-2-(4-chlorophenyl)ethenyl]sulfonyl]-4-piperidinemethanol

General Description

4-Piperidinemethanol is a cyclic secondary amine. Its standard molar enthalpies of combustion, sublimation and formation have been determined.

Synthesis

1126-09-6

6457-49-4

The general procedure for the synthesis of 4-hydroxymethylpiperidine from ethyl 4-piperidinecarboxylate was as follows: lithium aluminum hydride (LiAlH4, 10.10 g, 0.266 mol) was suspended in tetrahydrofuran (THF, 150 mL) at 0 °C. Subsequently, a solution of ethyl 4-piperidinecarboxylate (18.13 g, 0.120 mol) dissolved in THF (300 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, it was cooled in an ice bath and a mixture of water (14 mL) and THF (28 mL) was slowly added. Next, a mixture of 15% aqueous sodium hydroxide (14 mL) and water (37 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was filtered to remove the precipitate and the filtrate was concentrated to give 17.88 g of the target product 4-hydroxymethylpiperidine in quantitative yield.

References

[1] Patent: WO2004/76450, 2004, A1. Location in patent: Page 59
[2] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 27
[3] RSC Advances, 2016, vol. 6, # 22, p. 17929 - 17940
[4] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[5] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 773 - 791

4-Piperidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 2-(4-Chloromethylpiperidin-1-yl)pyrimidine-5-carboxamide ,97% 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxamide 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate (2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl)methanol 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate 2-(4-(Hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide 1-Boc-4-(aminomethyl)piperidine Terfenadine Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate (1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)methanol
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4-Piperidinemethanol Suppliers

Americas 1 Belgium 3 China 311 Czech Republic 1 Europe 2 France 3 Germany 8 India 20 Ireland 1 Italy 2 Japan 4 Slovakia 1 Switzerland 4 Ukraine 2 United Kingdom 19 United States 46 Global 428
YuChen Biological Medicine
Tel
0535-7295056 15692356085
Email
sdycc1234@163.com
Country
China
ProdList
158
Advantage
58
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375892 15553111391
Email
3276840968@qq.com
Country
China
ProdList
301
Advantage
58
JIANGYIN RUISHIPHARM CO.,LIMITED
Tel
0510-0510-66227179 18921203887
Fax
+86-0510-66227179 QQ:2200317867
Email
sales@ruishipharm.com
Country
China
ProdList
749
Advantage
58
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084; 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
392
Advantage
60
BTC Pharmaceutical CO. Ltd
Tel
15716293042 18862996710
Fax
0513-68015394
Email
15050603958@163.com
Country
China
ProdList
694
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
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View Lastest Price from 4-Piperidinemethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Piperidinemethanol 6457-49-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-13
Shaanxi Dideu Medichem Co. Ltd
Product
4-Piperidinemethanol 6457-49-4
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31
Henan Fengda Chemical Co., Ltd
Product
4-Piperidinemethanol 6457-49-4
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-17

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