Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
- Product Name
- Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
- CAS No.
- 875318-46-0
- Chemical Name
- Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
- Synonyms
- Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate;Ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate ,97%;5-Pyrimidinecarboxylic acid, 2-[4-(hydroxymethyl)-1-piperidinyl]-, ethyl ester
- CBNumber
- CB8547284
- Molecular Formula
- C13H19N3O3
- Formula Weight
- 265.31
- MOL File
- Mol file
Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate Property
- Boiling point:
- 447.7±41.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.94±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- Z3160
- Product name
- Ethyl2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- NUC0001679
- Product name
- ETHYL 2-[4-(HYDROXYMETHYL)PIPERIDIN-1-YL]PYRIMIDINE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $412.65
- Updated
- 2021/12/16
- Product number
- CM128244
- Product name
- ethyl2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $561
- Updated
- 2021/12/16
- Product number
- CD11038267
- Product name
- Ethyl2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- A128879
- Product name
- Ethyl2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $792
- Updated
- 2021/12/16
Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Synthesis
6457-49-4
148550-51-0
875318-46-0
Stage 1 - Coupling Reaction: Under nitrogen protection, piperidine-4-methanol (2.48 g, 21.55 mmol) was stirred with K2CO3 (8.9 g, 64.65 mmol) in a 1:1 solvent mixture of DMF/MeCN (20 mL) for 10 min at room temperature. Subsequently, ethyl 2-methylsulfonyl-5-pyrimidinecarboxylate (5 g, 21.55 mmol) was added and the reaction continued to be stirred for 20 min. After completion of the reaction, the reaction mixture was diluted with deionized water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent to afford the orange solid product ethyl 2-(4-hydroxymethylpiperidin-1-yl)pyrimidine-5-carboxylate (5.70 g, 99% yield). Mass spectrometry analysis showed m/z = 266 [M + H]+. The product was used directly in subsequent steps without further purification.
References
[1] Patent: WO2008/53131, 2008, A1. Location in patent: Page/Page column 51; 53
[2] Patent: WO2006/10750, 2006, A1. Location in patent: Page/Page column 30-31
[3] Patent: WO2007/82878, 2007, A1. Location in patent: Page/Page column 26
[4] Patent: WO2007/82882, 2007, A1. Location in patent: Page/Page column 30
Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +86-13916956214
- sales@victory-pharm.com
- Country
- China
- ProdList
- 1299
- Advantage
- 58
- Tel
- 0086-19817745290; +8619817745290
- bd@blocksynth.com
- Country
- China
- ProdList
- 5661
- Advantage
- 58
- Tel
- 15895968936
- Fax
- qq 1018762393
- 1018762393@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58