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Triethyl orthoformate

Product Name
Triethyl orthoformate
CAS No.
122-51-0
Chemical Name
Triethyl orthoformate
Synonyms
1,1';TEOF;ETHONE;AETHON;Formylolate;orthoformate;ortho-formic;ETHYL-O-FORMATE;Triethoxmethane;triethoxy-methan
CBNumber
CB4126252
Molecular Formula
C7H16O3
Formula Weight
148.2
MOL File
122-51-0.mol
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Triethyl orthoformate Property

Melting point:
-76 °C (lit.)
Boiling point:
146 °C (lit.)
Density 
0.891 g/mL at 25 °C (lit.)
vapor density 
5.11 (vs air)
vapor pressure 
2.9 mm Hg ( 20 °C)
refractive index 
n20/D 1.391(lit.)
Flash point:
86 °F
storage temp. 
Flammables area
form 
Liquid
color 
Clear colorless
Water Solubility 
1.35 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6884
BRN 
605384
InChIKey
GKASDNZWUGIAMG-UHFFFAOYSA-N
CAS DataBase Reference
122-51-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl orthoformate(122-51-0)
EPA Substance Registry System
Ethyl orthoformate (122-51-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
10-36-36/38
Safety Statements 
16-26-37/39-36-45-36/39
RIDADR 
UN 2524 3/PG 3
WGK Germany 
1
RTECS 
RM6475000
21
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29159080
Toxicity
LD50 orally in rats: 7.06 g/kg (Smyth)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
304050
Product name
Triethyl orthoformate
Purity
anhydrous, 98%
Packaging
2l
Price
$352
Updated
2021/12/16
Sigma-Aldrich
Product number
304050
Product name
Triethyl orthoformate
Purity
anhydrous, 98%
Packaging
1l
Price
$243
Updated
2021/12/16
Sigma-Aldrich
Product number
T60453
Product name
Triethyl orthoformate
Purity
reagent grade, 98%
Packaging
18 L
Price
$880
Updated
2021/12/16
Sigma-Aldrich
Product number
T60453
Product name
Triethyl orthoformate
Purity
reagent grade, 98%
Packaging
500ml
Price
$67.9
Updated
2021/03/22
Sigma-Aldrich
Product number
T60453
Product name
Triethyl orthoformate
Purity
reagent grade, 98%
Packaging
1l
Price
$102
Updated
2021/03/22
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Triethyl orthoformate Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

Labelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740).

Uses

A reagent useful for acetylization and imidic ester formation.

Uses

Triethyl orthoformate is used in Bodroux-Chichibabin aldehyde synthesis to prepare an aldehyde with one carbon higher by reacting with Grignard reagent. It is also used in the electrophilic formylation of activated aromatic species such as phenol.

General Description

A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate Preparation Products And Raw materials

Raw materials

Preparation Products

5-CARBETHOXYURACIL Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chloromethyltriethoxysilane 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- 1-CHLORO-4-ISOCYANOBENZENE 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE 1-CYCLOHEXYLURACIL METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE 2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID 2-AMINO-3,5-DICYANOPYRIDINE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE 4-Methylpyrimidine 3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-Chloro-7-(trifluoromethyl)quinoline 3-Aminopyrazole-4-carboxylic acid ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4,5-Dicyanoimidazole ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE Ethoxylated 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE N-FORMYLGLYCINE ETHYL ESTER 1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 4-Acetylphenylboronic acid 2-Formylfuran-5-boronic acid Diethoxymethyl acetate Estazolam 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE
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Triethyl orthoformate Suppliers

Jinan Hui Feng Da chemical Co., LTD.
Tel
0531-88872378- ;0531-88691896- ;0531-82687654-
Fax
0531-89702765
Email
jnhuifengda@163.com;3148353978@qq.com;3388693927@qq.com
Country
China
ProdList
574
Advantage
58
Changzhou Xuanming Chemical Co., Ltd.
Tel
Fax
0519-85190960
Email
36485073@qq.com
Country
China
ProdList
89
Advantage
58
Jinan Renyuan Chemical Co., Ltd.
Email
1840274076@qq.com
Country
CHINA
ProdList
214
Advantage
58
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546-
Fax
025-87193546
Email
chemweiao@163.com;
Country
China
ProdList
9076
Advantage
60
Shandong Yihong Chemical Co. LTD
Tel
13305392349
Fax
0539-7910696
Email
977495915@qq.com
Country
China
ProdList
496
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
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View Lastest Price from Triethyl orthoformate manufacturers

Wuhan Mulei New Material Technology Co. Ltd
Product
Triethyl orthoformate 122-51-0
Price
US $10.00/KG/Tin
Min. Order
1KG
Purity
99%
Supply Ability
5000tons per month
Release date
2021-04-01
Shandong Luning Pharmaceutical Co., Ltd.
Product
Triethyl Orthoformate ( TEOF ) 122-51-0
Price
US $606.00/T
Min. Order
1T
Purity
99%
Supply Ability
600T
Release date
2020-10-22
Hebei Crovell Biotech Co Ltd
Product
Triethyl orthoformate 122-51-0
Price
US $5.70/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-06-29

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