Triethyl orthoformate

Product Name: Triethyl orthoformate
CAS No.: 122-51-0
Chemical Name: Triethyl orthoformate
Synonyms: TRIETHOXYMETHANE;TEOF;ETHYL ORTHOFORMATE;orthoformate;ORTHOFORMIC ACID TRIETHYL ESTER;ETHONE;iethyl orthoforMate;1,1';TEOE;AETHON
CBNumber: CB4126252
Molecular Formula: C7H16O3
Formula Weight: 148.2
MOL File: 122-51-0.mol

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Triethyl orthoformate Property

Melting point:: -76 °C (lit.)
Boiling point:: 146 °C (lit.)
Density: 0.891 g/mL at 25 °C (lit.)
vapor density: 5.11 (vs air)
vapor pressure: 2.9 mm Hg ( 20 °C)
refractive index: n20/D 1.391(lit.)
Flash point:: 86 °F
storage temp.: Flammables area
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Liquid
color: Clear colorless
Water Solubility: 1.35 g/L
Sensitive: Moisture Sensitive
Merck: 14,6884
BRN: 605384
Stability:: Moisture Sensitive
InChIKey: GKASDNZWUGIAMG-UHFFFAOYSA-N
LogP: 1.2 at 20℃
CAS DataBase Reference: 122-51-0(CAS DataBase Reference)
NIST Chemistry Reference: Ethyl orthoformate(122-51-0)
EPA Substance Registry System: Ethyl orthoformate (122-51-0)

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Safety

Hazard Codes: Xi
Risk Statements: 10-36-36/38
Safety Statements: 16-26-37/39-36-45-36/39
RIDADR: UN 2524 3/PG 3
WGK Germany: 1
RTECS: RM6475000
F: 21
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29159080
Toxicity: LD50 orally in rats: 7.06 g/kg (Smyth)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H226Flammable liquid and vapour
Precautionary statements: P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T60453
Product name: Triethyl orthoformate
Purity: reagent grade, 98%
Packaging: 18L
Price: $1040
Updated: 2024/03/01

Sigma-Aldrich

Product number: 304050
Product name: Triethyl orthoformate
Purity: anhydrous, 98%
Packaging: 2l
Price: $262.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 304050
Product name: Triethyl orthoformate
Purity: anhydrous, 98%
Packaging: 1l
Price: $297
Updated: 2024/03/01

TCI Chemical

Product number: O0066
Product name: Triethyl Orthoformate
Purity: >98.0%(GC)
Packaging: 25mL
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: O0066
Product name: Triethyl Orthoformate
Purity: >98.0%(GC)
Packaging: 500mL
Price: $46
Updated: 2024/03/01

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Triethyl orthoformate Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

Triethyl orthoformate is used in Bodroux-Chichibabin aldehyde synthesis to prepare an aldehyde with one carbon higher by reacting with Grignard reagent. It is also used in the electrophilic formylation of activated aromatic species such as phenol.

Application

Sweet, somewhat camphoraceous-herbaceous odor with a Fimecdle-like note. Triethyl orthoformate has been suggested for use in industrial fragrances for masking, etc. and may find some application in that field. It tends to lift the odor of the conventional components of a pine fragrance and increase the radiation, an effect often desirable for masking purposes.

General Description

Triethyl orthoformate is a clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Health Hazard

Triethyl orthoformate may cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Triethyl orthoformate will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate triethyl orthoformate first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column. [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate Preparation Products And Raw materials

Raw materials

Ethanol Sodium Chloroform Sodium ethoxide Sodium ethylate solution,in ethyl alcohol Benzoyl chloride

Preparation Products

5-CARBETHOXYURACIL Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chloromethyltriethoxysilane 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- 1-CHLORO-4-ISOCYANOBENZENE 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE 1-CYCLOHEXYLURACIL METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE 2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID 2-AMINO-3,5-DICYANOPYRIDINE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE 4-Methylpyrimidine 3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-Chloro-7-(trifluoromethyl)quinoline 3-Aminopyrazole-4-carboxylic acid ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4,5-Dicyanoimidazole ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE Ethoxylated 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE N-FORMYLGLYCINE ETHYL ESTER 1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 4-Acetylphenylboronic acid 2-Formylfuran-5-boronic acid Diethoxymethyl acetate Estazolam 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE

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Triethyl orthoformate Suppliers

Americas 1 Belgium 2 Canada 1 China 404 Europe 4 Germany 8 India 45 Italy 1 Japan 6 Russia 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 7 United States 53 Global 536

Shanghai TongYuan Chemical Co., Ltd.

Tel: 021-021-69182866 13701855675
Fax: 021-69182022
Email: tongyuanchem@126.com
Country: China
ProdList: 4321
Advantage: 58

Jinan Hui Feng Da chemical Co., LTD.

Tel: 13156148719 15554103218
Fax: 0531-89702765
Email: jnhuifengda@163.com
Country: China
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Jinan Renyuan Chemical Co., Ltd.

Tel: 0531-86128689 18396852370
Fax: 0531-86128689
Email: 1840274076@qq.com
Country: China
ProdList: 279
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Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
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Changzhou KOYE Chemical Co.,LTD.

Tel: 519-81882581 18602584369
Email: Lydia@kwchem.com
Country: China
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Changzhou Chengyi Biotechnology Co., Ltd.

Tel: 13338800824
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Tangyuan Life Science (Shanghai) Co., Ltd

Tel: 400-618-1121 18616561988
Fax: 400-618-1121
Email: sales@townyuan.com
Country: China
ProdList: 3001
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Zibo Chuanggu Chemical Technology Co., Ltd.

Tel: 00-15864498288 15864498288
Email: 15864498288@163.cn
Country: China
ProdList: 43
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JINAN QUANSHENG CHEMICAL CO.,LTD

Tel: 0531-80962058 13012986817
Email: 961556194@qq.com
Country: China
ProdList: 77
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Tianjin Zhongxin Chemtech Co., Ltd.

Tel: 022-66880623
Fax: 86(0)22-66880086
Email: sales@tjzxchem.com
Country: China
ProdList: 613
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View Lastest Price from Triethyl orthoformate manufacturers

Ningxia Jinhua Chemical Co.,Ltd

Product: Triethyl Orthoformate 122-51-0
Price: US $0.00/Kg/Drum
Min. Order: 180KG
Purity: 99.4
Supply Ability: 1000kg
Release date: 2021-05-17

Hebei Weibang Biotechnology Co., Ltd

Product: Triethyl Orthoformate 122-51-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-31

Hebei Chuanghai Biotechnology Co,.LTD

Product: Triethyl orthoformate 122-51-0
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-22

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