2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
- Product Name
- 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
- CAS No.
- 16462-27-4
- Chemical Name
- 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
- Synonyms
- NSC 135235;2,4-DIAMINO-5-CYANO-PYRIMIDINE;2,4-Diaminopyrimidine-5-carbonitriL;2,4-DIAMINO-5-PYRIMIDINECARBONITRILE;2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE;5-Pyrimidinecarbonitrile, 2,4-diamino-;2,4-Diaminopyrimidine-5-carbonitrile ,97%;5-Pyrimidinecarbonitrile, 2,4-diamino- (6CI,8CI,9CI);2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE ISO 9001：2015 REACH
- CBNumber
- CB3683161
- Molecular Formula
- C5H5N5
- Formula Weight
- 135.13
- MOL File
- 16462-27-4.mol
2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE Property
- Melting point:
- 318 °C (decomp)
- Boiling point:
- 498.2±55.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMF (Slightly, Heated), DMSO (Slightly)
- form
- Solid
- pka
- 3.93±0.10(Predicted)
- color
- Light Yellow
Safety
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D416740
- Product name
- 2,4-Diaminopyrimidine-5-carbonitrile
- Packaging
- 500mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 271869
- Product name
- 2,4-Diaminopyrimidine-5-carbonitrile
- Packaging
- 100mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- FD21495
- Product name
- 2,4-Diaminopyrimidine-5-carbonitrile
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD21495
- Product name
- 2,4-Diaminopyrimidine-5-carbonitrile
- Packaging
- 250mg
- Price
- $182.5
- Updated
- 2021/12/16
- Product number
- CHM0975062
- Product name
- 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $210
- Updated
- 2021/12/16
2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
2,4-Diaminopyrimidine-5-carbonitrile is used as an intermediate for the preparation of medicines and agrochemicals (1).
Uses
Intermediate for the preparation of medicines and agrochemicals.
Synthesis
506-93-4
123-06-8
16462-27-4
General procedure for the synthesis of 2,4-diaminopyrimidine-5-carbonitrile from guanidine nitrate and ethoxymethylenemalonononitrile: 1.22 g (10 mmol) of guanidine nitrate was dissolved in 50 mL of sodium ethanolate ethanol solution, keeping the reaction temperature at 5°C, and 1.22 g (10 mmol) of ethoxymethylenemalononitrile was added slowly dropwise, the dropwise process lasted for 8 hours. Upon completion of the reaction, the reaction was quenched by the addition of an appropriate amount of water and extracted with ethyl acetate. The organic phases were combined and washed with saturated saline, followed by concentration of the organic phase by removing the solvent by distillation under reduced pressure. Finally, the residue was purified by silica gel column chromatography with an eluent ratio of dichloromethane:methanol=1:30 (v/v) to afford the white solid product 2,4-diaminopyrimidine-5-carbonitrile (compound of formula IV) in 71% yield.
References
[1] Patent: CN106938997, 2017, A. Location in patent: Paragraph 0048; 0058-0059
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 9, p. 3187 - 3197
2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE manufacturers
- Product
- 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE 16462-27-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-03-13