Trimethyl orthobenzoate
- Product Name
- Trimethyl orthobenzoate
- CAS No.
- 707-07-3
- Chemical Name
- Trimethyl orthobenzoate
- Synonyms
- (Trimethoxymethyl)benzene;Methyl orthobenzoate;Benzene, (trimethoxymethyl)-;SKL283;NSC-67391;Orthobenzoate;trimethyl benzoate;Intedanib Impurity 6;TRIMETHYL-O-BENZOATE;Sunitinib Impurity 71
- CBNumber
- CB9160297
- Molecular Formula
- C10H14O3
- Formula Weight
- 182.22
- MOL File
- 707-07-3.mol
Trimethyl orthobenzoate Property
- Boiling point:
- 87-88 °C/7 mmHg (lit.)
- Density
- 1.061 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.489(lit.)
- Flash point:
- 180 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in organic solvents.
- form
- Liquid
- color
- Clear colorless
- Sensitive
- Moisture Sensitive
- BRN
- 777623
- Stability:
- Hygroscopic
- InChI
- 1S/C10H14O3/c1-11-10(12-2,13-3)9-7-5-4-6-8-9/h4-8H,1-3H3
- InChIKey
- IECKAVQTURBPON-UHFFFAOYSA-N
- SMILES
- COC(OC)(OC)c1ccccc1
- CAS DataBase Reference
- 707-07-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, (trimethoxymethyl)-(707-07-3)
- EPA Substance Registry System
- Benzene, (trimethoxymethyl)- (707-07-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39
- WGK Germany
- 3
- TSCA
- TSCA listed
- HS Code
- 29163100
- Storage Class
- 10 - Combustible liquids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 164534
- Product name
- Trimethyl orthobenzoate
- Purity
- 98%
- Packaging
- 50g
- Price
- $534
- Updated
- 2026/03/19
- Product number
- 164534
- Product name
- Trimethyl orthobenzoate
- Purity
- 98%
- Packaging
- 10g
- Price
- $99.4
- Updated
- 2023/06/20
- Product number
- T2287
- Product name
- Trimethyl Orthobenzoate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $25
- Updated
- 2026/03/19
- Product number
- T2287
- Product name
- Trimethyl Orthobenzoate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $54
- Updated
- 2026/03/19
- Product number
- 9303AL
- Product name
- Trimethyl Orthobenzoate
- Packaging
- 100g
- Price
- $161
- Updated
- 2021/12/16
Trimethyl orthobenzoate Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Uses
Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067
General Description
Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.
Synthesis
The phenylbenzamide derivative (44.3 mmol) and methyl trifluoromethanesulfonate (5.93 mL, 52.5 mmol) were dissolved in dry dichloromethane (20 mL) and the reaction solution was stirred for 18 hours. Anhydrous ether (70 mL) was added to the reaction mixture to obtain benzimidazolium trifluoromethanesulfonate; the salt was separated by decantation. The salt was washed with anhydrous ether (10 mL) and redissolved in dichloromethane (20 mL). The mixture was cooled to 0C and the reaction mixture was treated with sodium methanol solution. The reaction mixture was stirred at room temperature for 10 minutes; the solvent was evaporated to give the crude aniline acetal mixed with the trifluoromethanesulfonate. The mixture was dissolved in hexane (150-200 mL) and filtered to remove the salt and the solvent was removed under vacuum. The acetal dissolved in anhydrous methanol (35 mL) was treated with glacial acetic acid (3.4 mL), the reaction mixture was treated with sodium methanol solution, the reaction mixture was stirred at room temperature for 15 minutes, and the reaction mixture was treated with K2CO3 (3 g). The solvent was evaporated and ether and water were added to the reaction mixture to separate the organic layer. The solvent was removed under vacuum to obtain the crude protic acid ester. The crude product was purified by fractional distillation at 0.1 mmHg to afford N-methylaniline at 25-30 C and trimethyl orthobenzoate at 90-100 C.
Trimethyl orthobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimethyl orthobenzoate manufacturers
- Product
- Trimethyl Orthobenzoate 707-07-3
- Price
- US $99.00-45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-12-18
- Product
- Trimethyl orthobenzoate 707-07-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- Trimethyl orthobenzoate 707-07-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22