Indications and Usage Uses synthesis
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Benzocaine

Indications and Usage Uses synthesis
Product Name
Benzocaine
CAS No.
94-09-7
Chemical Name
Benzocaine
Synonyms
Solu H;Norcain;Ora-jel;NSC 4688;Ethoform;Norcaine;Topcaine;ORTHESIN;Euphagin;Anaesthin
CBNumber
CB1217951
Molecular Formula
C9H11NO2
Formula Weight
165.19
MOL File
94-09-7.mol
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Benzocaine Property

Melting point:
88-90 °C
Boiling point:
172 °C (12.7517 mmHg)
Density 
1.17
refractive index 
1.5600 (estimate)
Flash point:
172°C/13mm
storage temp. 
2-8°C
solubility 
alcohol: soluble1 gm in 5 ml
pka
2.5(at 25℃)
form 
Crystalline Powder
color 
White
Water Solubility 
Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water
Merck 
14,1086
BRN 
638434
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
BLFLLBZGZJTVJG-UHFFFAOYSA-N
CAS DataBase Reference
94-09-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-amino-, ethyl ester(94-09-7)
EPA Substance Registry System
Benzocaine (94-09-7)
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Safety

Hazard Codes 
Xi,T,F
Risk Statements 
43-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
22-24/25-37/39-26-24-45-36/37-16-7
RIDADR 
3077
WGK Germany 
2
RTECS 
DG2450000
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29224995
Hazardous Substances Data
94-09-7(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 3042mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P321Specific treatment (see … on this label).

P391Collect spillage. Hazardous to the aquatic environment

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
06952
Product name
Benzocaine
Purity
tested according to Ph.Eur.
Packaging
100g
Price
$26.7
Updated
2020/08/18
Sigma-Aldrich
Product number
B0600000
Product name
Benzocaine
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1054000
Product name
Benzocaine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
A0271
Product name
Ethyl 4-Aminobenzoate
Purity
>99.0%(GC)(T)
Packaging
25g
Price
$18
Updated
2021/03/22
TCI Chemical
Product number
A0271
Product name
Ethyl 4-Aminobenzoate
Purity
>99.0%(GC)(T)
Packaging
500g
Price
$112
Updated
2021/03/22
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Benzocaine Chemical Properties,Usage,Production

Indications and Usage

Benzocaine is a colorless trapezial crystal. Its melting point is 92℃ (88-90℃), boiling point is 183-184°C (1.87kPa). 1g of this drug is soluble in about 2500ml water, 5ml ethanol, 2ml chloroform, 4ml ether or 30-50ml almond oil and olive oil, and it is also soluble in dilute acid. It is stable in air, odorless, and slightly bitter.
Benzocaine is a lipid-soluble surface anesthetic, and it weaker than other local anesthetics such as lidocaine and tetracaine, so it will not cause any discomfort due to its anesthetizing effects when acting on mucosa. Benzocaine is a type of drug with relatively strong lipid-solubility and will bind with mucosa and the fatty layer of skin, but it will not easily penetrate into the body and cause poisoning. Benzocaine can be used as a precursor for Ossur imitation, orthocaine, and procaine. It is also used as a local anesthetic and can stop pain and itching. It is mainly used in pain and itch prevention on wounds, ulcer surfaces, mucous membrane surfaces and hemorrhoids. Its paste form can also lubricate and stop pain for the nasopharynx and endoscope. Benzocaine’s aural solution is used to alleviate acute congestion, concentrated otitis externa, and the pain and itching of swimming otitis. Benzocaine is also effective for toothaches, sore throat, oral ulcers, all kinds of hemorrhoids, anal fissures, and vulvar itching. Benzocaine can be used as a male sex organ numbing agent to slow ejaculation. It can also be used as a numbing lubricant for the pharynx and endoscope, and it can be used as a UV absorbing agent for cosmetics.

Uses

  1. Benzocaine is a local anaesthetic of the ester type with a poor solubility in water. The drug benzocaine is normally used as a topical pain reliever or as a common ingredient in cough drops. Benzocaine is used in multiple forms including lotion, gel, liquid, lozenges, and sprays. When Benzocaine is applied in any form it temporarily numbs or blocks the nerve endings, which leads to a decreases in the amount of pain. It is used in cattle, sheep, swine and horses for local and prolonged low epidural anaesthesia. Standard therapeutic doses of benzocaine ranged from 150 to 750 mg per animal. Benzocaine is also currently used as surface anaesthetic as ointments (0.5% benzocaine) for wounds and ulcerated surfaces in horses, cattle and sheep applied twice a day until healing.
  2. A commonly used topical pain reliever. Main active ingredient in anesthetic ointments.
  3. Anesthetic;Na+ channel blocker
  4. Benzocaine acts on the central nervous system, cardiovascular system, neuromuscular junctions and ganglion synapse. Its mechanism of action is to prevent the generation and conduction of the nerve impulse. Local anaesthetics block conduction by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that is produced by a slight depolarisation. This action of local anaesthetics is due to their direct interaction with voltage-sensitive Na+ channels. Benzocaine is mainly hydroxylated in the metabolite para-aminobenzoic acid (PABA) that inhibits the action of sulphonamides.
  5. Benzocaine is distributed in the body, crosses the placenta and is metabolised in the liver and in the plasma by non-specific cholinesterases. Benzocaine and its main metabolite (para-aminobenzoic acid) are excreted into urine.
  6. Benzocaine appears as a moderately toxic compound after single administration. The acute intraperitoneal LD50 value was 216 mg/kg bw in mice. Benzocaine may induce methemoglobinemia in several species such as sheep, cats and dogs.

synthesis

the synthesis of benzocaine is carried out by the acid-catalyzed esterification of 4-aminobenzoic acid with ethanol:

In a 5-mL round bottom flask, add 120 mg of 4-aminobenzoic acid (often called PABA for paminobenzoic acid), 1.5 mL of absolute ethanol (absolute ethanol is completely free of water and can be found on the hooded shevles), and 3 boiling chips. Heat this mixture on a sand bath until all the solid dissolves. Cool in ice and then add 0.25 mL of concentrated sulfuric acid dropwise. (One drop at a time.) A large amount of precipitate will form when the sulfuric acid is added, but this will dissolve during the reflux that follows. Attach an air condenser from the microscale kit, and reflux gently for 60- 75 min. Check periodically to be sure that the mixture is refluxing gently, and that the ring of condensation of solvent lies somewhere along the inner surface of the air condenser; loss of solvent will cause overheating and a significant decrease in yield.

Description

Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.

Chemical Properties

white odourless crystals

Uses

Benzocaine is used as an anesthetic (local).

Uses

Local and topical anesthetic used in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.

Uses

Apply to a maximum of three to four times a day to the affected area, as directed by the physician.

brand name

Americaine (Fisons); Baby Anbesol (Whitehall-Robins).

Biological Functions

Benzocaine is a PABA derivative used primarily for topical application to skin and mucous membranes. Its low aqueous solubility allows it to stay at the site of application for long periods. Its minimal rate of absorption after topical administration is associated with a low incidence of systemic toxicity. Benzocaine is contraindicated in patients with known sensitivity to ester-linked anesthetics or PABA-containing compounds.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 4154, 1949 DOI: 10.1021/ja01180a513
Chemical and Pharmaceutical Bulletin, 29, p. 1443, 1981 DOI: 10.1248/cpb.29.1443

General Description

Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH.Because it is uncharged, it is not water soluble but is ideal fortopical applications. The onset of action is within 30 secondsand the duration of drug action is 10 to 15 minutes.

Clinical Use

Benzocaine is used for endoscopy, bronchoscopy, and topicalanesthesia. Benzocaine is available as a 20% solution topicalspray, in a 1% gel for mucous membrane application, and a14% glycerin suspension for topical use in the outer ear.Toxicity to benzocaine can occur when the topical doseexceeds 200 to 300 mg resulting in methemoglobinemia.Infants and children are more susceptible to this and methemoglobinemiahas been reported after benzocaine lubricationof endotracheal tubes and after topical administration to treata painful diaper rash.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by rectal route: methemoglobinemia/carboxyhemoglobinem ia in infants. A skin irritant and a mild sensitizer. Local contact may cause contact dermatitis. Used as a topical anesthetic and as a sun-screening agent. When heated to decomposition it emits highly toxic fumes of NOx. See also ETHYL ALCOHOL and ESTERS

Chemical Synthesis

Benzocaine is the ethyl ester of 4-aminobenzoic acid (2.3.1). The classic, optimal way of benzocaine synthesis is the reduction of the nitro group of the ethyl ester of 4-nitrobenzoic acid to benzocaine by hydrogen, which generates directly in the reaction medium by the reaction of iron filings with dilute acids [24–26].

Purification Methods

Crystallise Benzocaine from EtOH/H2O or EtOH (m 93-94o), and dry it in air. [Beilstein 14 H 422, 14 IV 1129.]

Structure and conformation

Ethyl aminobenzoate, a para-aminobenzoate derivative (PABA)

Benzocaine Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzocaine Suppliers

-
Tel
--
Fax
--
Email
17310985352@163.com
Country
China
ProdList
47
Advantage
58
Changzhou Sunlight Pharmaceutical Co., Ltd
Tel
0519-83131668;0519-83137042
Fax
+86-519-83138041
Email
info@sunlightchem.com;info@sunlightchem.com
Country
China
ProdList
90
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69
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
0519-85269522
Fax
013660798926
Email
sunlight68@126.com
Country
China
ProdList
99
Advantage
60
Changzhou Sunlight Farmacéutica.S.L.
Tel
0519-83138357-
Fax
0519-83138041
Email
810308@sunlightchem.com;
Country
China
ProdList
38
Advantage
60
Changzhou Yonghe Fine Chemical Co., Ltd.
Tel
0519-88552298
Fax
86-519-88552298
Email
xuxiaosong1972@163.com
Country
China
ProdList
47
Advantage
65
Hebei Guanlang Biotechnology Co., Ltd.
Email
515253120@qq.com
Country
China
ProdList
311
Advantage
58
Anhui Rencheng Technology Co., Ltd
Tel
Email
admin@ahrencheng.com
Country
China
ProdList
42
Advantage
58
hebei crovell biotech Co,.LTD
Tel
Email
mia@crovellbio.com
Country
China
ProdList
366
Advantage
58
Guangdong Xianqiang Pharmaceutical Co., Ltd.
Tel
020-87815159-
Email
tanshuhua@xianqiang.com
Country
China
ProdList
30
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Benzocaine manufacturers

Hanhong Medicine Technology (Hubei) Co., Ltd.
Product
Benzocaine 94-09-7
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200 ton
Release date
2021-05-21
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Benzocaine base
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-01-16
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Benzocaine base 94-09-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-27

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