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4-Fluorobenzoic acid

Description Reference
Product Name
4-Fluorobenzoic acid
CAS No.
456-22-4
Chemical Name
4-Fluorobenzoic acid
Synonyms
PFBA;P-FLUOROBENZOIC ACID;potassium 2,2,3,3,3-pentafluoropropanoate;4-fluoro-benzoicaci;The acid;AKOS 92636;p-Fluorobenzoic;fluorobenzoicacid;Fluoro benzoic ac;4-Fluorbenzoesure
CBNumber
CB4853637
Molecular Formula
C7H5FO2
Formula Weight
140.11
MOL File
456-22-4.mol
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4-Fluorobenzoic acid Property

Melting point:
182-184 °C (lit.)
Boiling point:
117 °C
Density 
1.479
storage temp. 
Sealed in dry,Room Temperature
solubility 
alcohol: soluble
form 
Crystalline Powder
pka
4.15(at 25℃)
color 
White to slightly yellow
Water Solubility 
Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water.
Merck 
14,4171
BRN 
1906922
InChIKey
BBYDXOIZLAWGSL-UHFFFAOYSA-N
CAS DataBase Reference
456-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-fluoro-(456-22-4)
EPA Substance Registry System
Benzoic acid, 4-fluoro- (456-22-4)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-41-36/37/38
Safety Statements 
26-39-24/25-22-37/39-36
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
128384
Product name
4-Fluorobenzoic acid
Purity
98%
Packaging
5g
Price
$17.8
Updated
2024/03/01
Sigma-Aldrich
Product number
128384
Product name
4-Fluorobenzoic acid
Purity
98%
Packaging
25g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
F0112
Product name
4-Fluorobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$47
Updated
2024/03/01
Alfa Aesar
Product number
A14129
Product name
4-Fluorobenzoic acid, 98%
Packaging
25g
Price
$34.4
Updated
2024/03/01
Alfa Aesar
Product number
A14129
Product name
4-Fluorobenzoic acid, 98%
Packaging
100g
Price
$77.65
Updated
2024/03/01
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4-Fluorobenzoic acid Chemical Properties,Usage,Production

Description

4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the 18F labeling of antibodies. It has been used in high resolution charge density study.

Reference

AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorobenzoic acid has been used in high resolution charge density study.

Definition

ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4.

Purification Methods

Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.]

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4-Fluorobenzoic acid Suppliers

Hebei Zhenjia new material Co., LTD
Tel
0319-5925599 13315915972
Email
13313090628@163.com
Country
China
ProdList
3491
Advantage
58
Weifang Mingran Chemical Co., Ltd.
Tel
15066331899,0536-2082396,117761326 15063661899
Fax
0536-2082397
Email
mingranchem@163.com
Country
China
ProdList
429
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
851
Advantage
58
Weifang Siyuan Chemical Co., Ltd.
Tel
0536-8888106 17663601818
Fax
0536-8888106
Email
2354379876@qq.com
Country
China
ProdList
244
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323 15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Danyang Wanlong Chemical Co., Ltd
Tel
86-511-8681 0993
Fax
0511-86810666
Email
jeff@wanlongchem.com
Country
China
ProdList
63
Advantage
55
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
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View Lastest Price from 4-Fluorobenzoic acid manufacturers

Speranza Chemical Co., Ltd.
Product
4-Fluorobenzoic acid 456-22-4
Price
US $15.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300MT/year
Release date
2019-12-24
Henan Fengda Chemical Co., Ltd
Product
4-Fluorobenzoic acid 456-22-4
Price
US $9.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-23
Shanghai UCHEM Inc.
Product
4-Fluorobenzoic acid 456-22-4
Price
US $38.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100kg
Release date
2023-10-30

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