2,4,5-Trifluorobenzoic acid

Product Name: 2,4,5-Trifluorobenzoic acid
CAS No.: 446-17-3
Chemical Name: 2,4,5-Trifluorobenzoic acid
Synonyms: 2,4,5-Trilfuorobenzoic acid;2,4,5-TrifL;RARECHEM AL BO 0258;2,4,5-Trifluorobenzo;5-Trifluorobenzoic acid;2,4,5-tifluorobenzoicacid;2,4,5-TRIFLUOROBENZOIC ACID;Benzoic acid, 2,4,5-trifluoro-;2,4,5-Trifluorobenzoic acid 99%;2,4,5-Trifluorobenzoic acid ,99%
CBNumber: CB1742985
Molecular Formula: C7H3F3O2
Formula Weight: 176.09
MOL File: 446-17-3.mol

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2,4,5-Trifluorobenzoic acid Property

Melting point:: 94-96 °C (lit.)
Boiling point:: 241.9±35.0 °C(Predicted)
Density: 1.4362 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
pka: 2.87±0.10(Predicted)
color: Off-White
BRN: 3257609
InChIKey: AKAMNXFLKYKFOJ-UHFFFAOYSA-N
CAS DataBase Reference: 446-17-3(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 2,4,5-trifluoro- (446-17-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 328154
Product name: 2,4,5-Trifluorobenzoic acid
Purity: 99%
Packaging: 5g
Price: $25.62
Updated: 2024/03/01

TCI Chemical

Product number: T1586
Product name: 2,4,5-Trifluorobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $54
Updated: 2024/03/01

TCI Chemical

Product number: T1586
Product name: 2,4,5-Trifluorobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $216
Updated: 2024/03/01

Alfa Aesar

Product number: A14193
Product name: 2,4,5-Trifluorobenzoic acid, 98%
Packaging: 5g
Price: $94.65
Updated: 2024/03/01

Alfa Aesar

Product number: A14193
Product name: 2,4,5-Trifluorobenzoic acid, 98%
Packaging: 1g
Price: $30.5
Updated: 2021/12/16

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2,4,5-Trifluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.

Preparation

Synthesis of 2,4,5-trifluorobenzoic acid: Tetrachloroisophthalonitrile was used as the starting material, which was fluoridated, selectively reduced, and partially defluoridated to obtain 2,4,5-trifluoroisophthalonitrile. This compound was hydrolyzed to form 2,4,5-trifluoroisophthalic acid. Then, selective decarboxylation of 2,4,5-trifluorobenzoic acid was carried out to prepare 2,4,5-trifluorobenzoic acid.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 168, 1991 DOI: 10.1021/jm00105a025

General Description

2,4,5-Trifluorobenzoic acid is an important quinolone antibacterial intermediate. It is used in the synthesis of Temafloxacin and liquid crystals, among others.

2,4,5-Trifluorobenzoic acid Preparation Products And Raw materials

Raw materials

1,2,4-Trifluorobenzene Isophthalic acid Chlorothalonil 2,4-Difluoroaniline

Preparation Products

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2,4,5-Trifluorobenzoic acid Suppliers

Belgium 4 Canada 3 China 351 Europe 3 France 2 Germany 6 India 9 Italy 1 Japan 4 Jordan 1 Russia 1 Slovakia 1 South Korea 3 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 23 United States 52 Global 470

Shanghai Harvest Chemical Industrial Co., Ltd.

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Shanghai Troedsson Technology Co., LTD

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Shandong Ruibowen New Material Technology Co., Ltd

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ZhengZhou HuaWen Chemical Co.Ltd

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 2,4,5-Trifluorobenzoic acid manufacturers

Speranza Chemical Co., Ltd.

Product: 2,4,5-trifluorobenzoic acid 446-17-3
Price: US $20.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 446-17-3
Release date: 2019-12-24

Henan Fengda Chemical Co., Ltd

Product: 2,4,5-Trifluorobenzoic acid 446-17-3
Price: US $35.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-19

Hebei Duling International Trade Co. LTD

Product: 2,4,5-Trifluorobenzoic acid 446-17-3
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-04-20

446-17-3, 2,4,5-Trifluorobenzoic acidRelated Search:

ALUMINUM FORMATE 3-(Trifluoromethyl)benzoic acid Triethyl orthoformate Florfenicol Trimethoxymethane Pentafluorobenzoic acid Trimesic acid 4-Fluorobenzoic acid 1,3,5-Trifluorobenzene 2,4,5-Trifluorobenzyl alcohol 2,3,4-Trifluorobenzoic acid Tetrafluorophthalic anhydride 3-HYDROXY-2,4,5-TRIFLUOROBENZOIC ACID METHYL PENTAFLUOROBENZOATE Tetrafluorophthalic acid ETHYL PENTAFLUOROBENZOATE 2,3,4,5-Tetrafluorobenzoic acid 3-METHOXY-2,4,5-TRIFLUOROBENZOIC ACID,3-Methoxy-2,4,5-Trifluorobenzoic Acid 2,4,5-Trifluoro-3-Methoxybenzoic Acid

2,4-trifluorobenzoic acid and derivatives

2,4,5-Trilfuorobenzoic acid

2,4,5-TRIFLUOROBENZOIC ACID AND THE DERIVATIVES

2,4,5-TrifluoroBenzoicacidsolution

2,4,5-Trifluorobenzoic acid, 99.5+%

2,4,5-Trifluorobenzoic acid 20% solution

2,4,5-Trifluorobenzoic acid 99%

RARECHEM AL BO 0258

2,4,5-Trifluorobenzoic acid ,99%

2,4,5-Trifluorobenzo

2,4,5-Trifluorobenzoic acid, 99.5+%, 99.5+%

5-Trifluorobenzoic acid

2,4,5-tifluorobenzoicacid

2,4,5-TRIFLUOROBENZOIC ACID

2,4,5-TrifL

Benzoic acid, 2,4,5-trifluoro-

446-17-3

Carbonyl Compounds

Carboxylic Acids

ARYL ACID

Organic Building Blocks

C7

Building Blocks

Pyridines ,Halogenated Heterocycles

C7

Carbonyl Compounds

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

Miscellaneous

blocks

Carboxes

FluoroCompounds

bc0001