Ethyl cyanoformate

Product Name: Ethyl cyanoformate
CAS No.: 623-49-4
Chemical Name: Ethyl cyanoformate
Synonyms: NSC 65347;C2H5OC(O)CN;cyanoformate;ETHYL CYANOFORMATE;Ethylcyanoformate,99%;ethyl carbonocyanidate;Ethyl cyanoformate 99%;Ethoxycarbonyl Cyanide;Ethyl cyanocarboxylate;Ethyl Cyanoformate >
CBNumber: CB8854001
Molecular Formula: C4H5NO2
Formula Weight: 99.09
MOL File: 623-49-4.mol

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Ethyl cyanoformate Property

Boiling point:: 115-116 °C (lit.)
Density: 1.003 g/mL at 25 °C (lit.)
refractive index: n20/D 1.381(lit.)
Flash point:: 76 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Miscible with chloroform and methanol.
form: Liquid
Specific Gravity: 1.01
color: Clear colorless
Sensitive: Moisture Sensitive
BRN: 635955
Exposure limits: NIOSH: IDLH 25 mg/m3
CAS DataBase Reference: 623-49-4(CAS DataBase Reference)
NIST Chemistry Reference: NCCOOC2H5(623-49-4)
EPA Substance Registry System: Carbonocyanidic acid, ethyl ester (623-49-4)

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Safety

Hazard Codes: T,F
Risk Statements: 10-23/24/25-34-36/37/38
Safety Statements: 26-36/37/39-45-24/25-16-7/9
RIDADR: UN 3275 6.1/PG 2
WGK Germany: 3
F: 10-19-21
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E18859
Product name: Ethyl cyanoformate
Purity: 99%
Packaging: 10g
Price: $86.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: E18859
Product name: Ethyl cyanoformate
Purity: 99%
Packaging: 50g
Price: $114
Updated: 2024/03/01

TCI Chemical

Product number: C1266
Product name: Ethyl Cyanoformate
Purity: >98.0%(GC)
Packaging: 5g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: C1266
Product name: Ethyl Cyanoformate
Purity: >98.0%(GC)
Packaging: 25g
Price: $98
Updated: 2024/03/01

Alfa Aesar

Product number: L15777
Product name: Ethyl cyanoformate, 99%
Packaging: 5g
Price: $39.1
Updated: 2024/03/01

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Ethyl cyanoformate Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.

Uses

Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.

Uses

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:

Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.

Application

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes.

Purification Methods

Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.]

Precautions

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Ethyl cyanoformate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl cyanoformate Suppliers

Americas 1 Belgium 2 Canada 1 China 194 Europe 3 Germany 5 India 16 Japan 5 Poland 1 Slovakia 1 Switzerland 2 United Kingdom 8 United States 25 Global 264

Changzhou Mailekang Pharmaceutical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Alfa Aesar

Tel: 400-6106006
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Email: saleschina@alfa-asia.com
Country: China
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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from Ethyl cyanoformate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Ethyl cyanoformate 623-49-4
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

Baoji Guokang Bio-Technology Co., Ltd.

Product: Ethyl cyanoformate 623-49-4
Price: US $157.00/ASSAYS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 tons
Release date: 2021-06-07

Honest Joy Holdings Limited

Product: EthylCarbonocyanidate 623-49-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.6%
Supply Ability: 100 tons
Release date: 2022-01-14

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Ethyl cyanoformate 99%

CYANOFORMIC ACID ETHYL ESTER

ETHYL CYANOFORMATE

2-ethoxy-2-oxoacetonitrile

[(Cyanocarbonyl)oxy]ethane

C2H5OC(O)CN

carbocyanidicacidethylester

Carbonocyanidic acid, ethyl ester

cyanoformate

carbonocyanidicacid,ethylester

Formic acid, cyano-, ethyl ester

Nitriloaceticacidethylester

Ethoxycarbonyl Cyanide

NSC 65347

Ethylcyanoformate,99%

Ethyl cyanocarboxylate

Ethyl Cyanoformate &gt

Formicacid, cyano-, ethyl este

623-49-4

NCCOOC2H5

C4H5NO2

NCCO2C2H5

NCCO2CH2CH3

Esters

Organic Building Blocks

Building Blocks

C2 to C5

Carbonyl Compounds

Aliphatics

Esters

C2 to C5

Carbonyl Compounds

Building Blocks

C2 to C5

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

john's