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Ethyl cyanoformate

Product Name
Ethyl cyanoformate
CAS No.
623-49-4
Chemical Name
Ethyl cyanoformate
Synonyms
NSC 65347;C2H5OC(O)CN;cyanoformate;ETHYL CYANOFORMATE;Ethylcyanoformate,99%;ethyl carbonocyanidate;Ethyl cyanoformate 99%;Ethoxycarbonyl Cyanide;Ethyl cyanocarboxylate;Ethyl Cyanoformate >
CBNumber
CB8854001
Molecular Formula
C4H5NO2
Formula Weight
99.09
MOL File
623-49-4.mol
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Ethyl cyanoformate Property

Boiling point:
115-116 °C (lit.)
Density 
1.003 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.381(lit.)
Flash point:
76 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Miscible with chloroform and methanol.
form 
Liquid
color 
Clear colorless
Specific Gravity
1.01
Sensitive 
Moisture Sensitive
BRN 
635955
CAS DataBase Reference
623-49-4(CAS DataBase Reference)
NIST Chemistry Reference
NCCOOC2H5(623-49-4)
EPA Substance Registry System
Carbonocyanidic acid, ethyl ester (623-49-4)
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Safety

Hazard Codes 
T,F
Risk Statements 
10-23/24/25-34-36/37/38
Safety Statements 
26-36/37/39-45-24/25-16-7/9
RIDADR 
UN 3275 6.1/PG 2
WGK Germany 
3
10-19-21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H300Fatal if swallowed

H310Fatal in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P320Specific treatment is urgent (see … on this label).

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E18859
Product name
Ethyl cyanoformate
Purity
99%
Packaging
10g
Price
$58.1
Updated
2021/12/16
Sigma-Aldrich
Product number
E18859
Product name
Ethyl cyanoformate
Purity
99%
Packaging
50g
Price
$213
Updated
2021/12/16
TCI Chemical
Product number
C1266
Product name
Ethyl Cyanoformate
Purity
>98.0%(GC)
Packaging
5g
Price
$30
Updated
2021/12/16
TCI Chemical
Product number
C1266
Product name
Ethyl Cyanoformate
Purity
>98.0%(GC)
Packaging
25g
Price
$86
Updated
2021/12/16
Alfa Aesar
Product number
L15777
Product name
Ethyl cyanoformate, 99%
Packaging
25g
Price
$98.5
Updated
2021/12/16
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Ethyl cyanoformate Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.

Uses

Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.

Application

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes.

Purification Methods

Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.]

Precautions

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Ethyl cyanoformate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl cyanoformate Suppliers

OrgSynChem (Beijing) Technology Co., LTD.
Tel
010-52860678
Fax
010-60300056
Email
orgsyn-chem@163.com
Country
China
ProdList
3067
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280-
Email
sales01@aikonchem.com
Country
China
ProdList
16689
Advantage
50
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-86838766-
Email
2258830676@qq.com
Country
China
ProdList
3491
Advantage
58
Jinan Wanduoxin Chemical Co., Ltd.
Tel
531-88770993- ;531-88275220-
Fax
0531-88275220
Email
wonderfulchem@163.com;wonderfulchem@126.com
Country
China
ProdList
86
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
400-025-5188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
6456
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
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View Lastest Price from Ethyl cyanoformate manufacturers

Honest Joy Holdings Limited
Product
EthylCarbonocyanidate 623-49-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.6%
Supply Ability
100 tons
Release date
2022-01-14
Baoji Guokang Bio-Technology Co., Ltd.
Product
Ethyl cyanoformate 623-49-4
Price
US $157.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
10 tons
Release date
2021-06-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl cyanoformate 623-49-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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