Ethyl cyanoformate
- Product Name
- Ethyl cyanoformate
- CAS No.
- 623-49-4
- Chemical Name
- Ethyl cyanoformate
- Synonyms
- NSC 65347;C2H5OC(O)CN;cyanoformate;ETHYL CYANOFORMATE;Ethylcyanoformate,99%;ethyl carbonocyanidate;Ethyl cyanoformate 99%;Ethoxycarbonyl Cyanide;Ethyl cyanocarboxylate;Ethyl Cyanoformate >
- CBNumber
- CB8854001
- Molecular Formula
- C4H5NO2
- Formula Weight
- 99.09
- MOL File
- 623-49-4.mol
Ethyl cyanoformate Property
- Boiling point:
- 115-116 °C (lit.)
- Density
- 1.003 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.381(lit.)
- Flash point:
- 76 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Miscible with chloroform and methanol.
- form
- Liquid
- Specific Gravity
- 1.01
- color
- Clear colorless
- Sensitive
- Moisture Sensitive
- BRN
- 635955
- Exposure limits
- NIOSH: IDLH 25 mg/m3
- CAS DataBase Reference
- 623-49-4(CAS DataBase Reference)
- NIST Chemistry Reference
- NCCOOC2H5(623-49-4)
- EPA Substance Registry System
- Carbonocyanidic acid, ethyl ester (623-49-4)
Safety
- Hazard Codes
- T,F
- Risk Statements
- 10-23/24/25-34-36/37/38
- Safety Statements
- 26-36/37/39-45-24/25-16-7/9
- RIDADR
- UN 3275 6.1/PG 2
- WGK Germany
- 3
- F
- 10-19-21
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- E18859
- Product name
- Ethyl cyanoformate
- Purity
- 99%
- Packaging
- 10g
- Price
- $86.5
- Updated
- 2024/03/01
- Product number
- E18859
- Product name
- Ethyl cyanoformate
- Purity
- 99%
- Packaging
- 50g
- Price
- $114
- Updated
- 2024/03/01
- Product number
- C1266
- Product name
- Ethyl Cyanoformate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2024/03/01
- Product number
- C1266
- Product name
- Ethyl Cyanoformate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $98
- Updated
- 2024/03/01
- Product number
- L15777
- Product name
- Ethyl cyanoformate, 99%
- Packaging
- 5g
- Price
- $39.1
- Updated
- 2024/03/01
Ethyl cyanoformate Chemical Properties,Usage,Production
Chemical Properties
Clear Colourless Liquid
Uses
Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.
Uses
Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.
Uses
Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
- Activated olefins in the presence of a titanium catalyst.
- Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
- Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Application
Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes.
Purification Methods
Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.]
Precautions
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.
Ethyl cyanoformate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl cyanoformate Suppliers
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View Lastest Price from Ethyl cyanoformate manufacturers
- Product
- Ethyl cyanoformate 623-49-4
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
- Product
- Ethyl cyanoformate 623-49-4
- Price
- US $157.00/ASSAYS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2021-06-07
- Product
- EthylCarbonocyanidate 623-49-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14