4-Aminophthalic acid
- Product Name
- 4-Aminophthalic acid
- CAS No.
- 5434-21-9
- Chemical Name
- 4-Aminophthalic acid
- Synonyms
- AKOS 92080;4-AminophthaL;4-aminophthalate;4-Aminophthalsure;RARECHEM AL BO 1135;4-Amnophthalic acid;4-AMINOPHTHALIC ACID;4-AminophthalicAcid>4-Aminophthalicacid,98%;4-Amino-o-phthalic acid
- CBNumber
- CB8287890
- Molecular Formula
- C8H7NO4
- Formula Weight
- 181.15
- MOL File
- 5434-21-9.mol
4-Aminophthalic acid Property
- Melting point:
- 344 °C (dec.)(lit.)
- Boiling point:
- 465.1±40.0 °C(Predicted)
- Density
- 1.551±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 3.41±0.10(Predicted)
- color
- White to Gray to Brown
- BRN
- 2723405
- Major Application
- peptide synthesis
- InChI
- InChI=1S/C8H7NO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)
- InChIKey
- OXSANYRLJHSQEP-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=CC=C(N)C=C1C(O)=O
- CAS DataBase Reference
- 5434-21-9(CAS DataBase Reference)
- EPA Substance Registry System
- 4-Aminophthalic acid (5434-21-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 524716
- Product name
- 4-Aminophthalic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $58.8
- Updated
- 2022/05/15
- Product number
- A1512
- Product name
- 4-Aminophthalic Acid
- Purity
- >95.0%(T)
- Packaging
- 5g
- Price
- $91
- Updated
- 2025/07/31
- Product number
- A1512
- Product name
- 4-Aminophthalic Acid
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $270
- Updated
- 2025/07/31
- Product number
- A627713
- Product name
- 4-Aminophthalic Acid
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A627713
- Product name
- 4-Aminophthalic Acid
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
4-Aminophthalic acid Chemical Properties,Usage,Production
Chemical Properties
Beige powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
610-27-5
5434-21-9
The general procedure for the synthesis of 4-amino phthalic acid from 4-nitrophthalic acid was as follows: 1 g (4.73 mmol) of 4-nitrophthalic acid was dissolved in 10 ml of anhydrous ethanol. The solution was stirred and degassed at room temperature and under argon protection. Subsequently, 50 mg of 5% palladium/carbon catalyst was added at once and hydrogen was passed into the solution for hydrogenation reaction. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated by evaporation to give an orange oily product with a mass of 820 mg and a yield of 96%. The structure of the product was confirmed by 1H NMR (DMSO-d6) with the following chemical shifts: 3.32 (1H, s), 5.95 (1H, s), 6.49-6.53 (2H, m), 7.46-7.50 (1H, d, J = 8.8 Hz), 12.33 (2H, COOH, s).
References
[1] Patent: US6689922, 2004, B1. Location in patent: Page column 20
[2] Patent: US6706725, 2004, B1. Location in patent: Page column 11
[3] Chemical Communications, 2017, vol. 53, # 62, p. 8751 - 8754
[4] Justus Liebigs Annalen der Chemie, 1881, vol. 208, p. 230
[5] Journal of the American Chemical Society, 1908, vol. 30, p. 1143
4-Aminophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminophthalic acid manufacturers
- Product
- 4-Aminophthalic acid 5434-21-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 4-Aminophthalic acid 5434-21-9
- Price
- US $167.44/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 98.50%HPLC
- Supply Ability
- 6tons/month
- Release date
- 2021-09-23
- Product
- Pomalidomide Impurity 45 5434-21-9
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-27