ChemicalBook > CAS DataBase List > 4-Aminophthalic acid

4-Aminophthalic acid

Product Name
4-Aminophthalic acid
CAS No.
5434-21-9
Chemical Name
4-Aminophthalic acid
Synonyms
AKOS 92080;4-AminophthaL;4-aminophthalate;4-Aminophthalsure;RARECHEM AL BO 1135;4-Amnophthalic acid;4-AMINOPHTHALIC ACID;4-AminophthalicAcid>4-Aminophthalicacid,98%;4-Amino-o-phthalic acid
CBNumber
CB8287890
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
5434-21-9.mol
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4-Aminophthalic acid Property

Melting point:
344 °C (dec.)(lit.)
Boiling point:
465.1±40.0 °C(Predicted)
Density 
1.551±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
3.41±0.10(Predicted)
color 
White to Gray to Brown
BRN 
2723405
InChI
InChI=1S/C8H7NO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)
InChIKey
OXSANYRLJHSQEP-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=CC=C(N)C=C1C(O)=O
CAS DataBase Reference
5434-21-9(CAS DataBase Reference)
EPA Substance Registry System
4-Aminophthalic acid (5434-21-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
TSCA 
Yes
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
524716
Product name
4-Aminophthalic acid
Purity
97%
Packaging
1g
Price
$58.8
Updated
2022/05/15
TCI Chemical
Product number
A1512
Product name
4-Aminophthalic Acid
Purity
>95.0%(T)
Packaging
5g
Price
$91
Updated
2025/07/31
TCI Chemical
Product number
A1512
Product name
4-Aminophthalic Acid
Purity
>95.0%(T)
Packaging
25g
Price
$270
Updated
2025/07/31
TRC
Product number
A627713
Product name
4-Aminophthalic Acid
Packaging
2.5g
Price
$45
Updated
2021/12/16
TRC
Product number
A627713
Product name
4-Aminophthalic Acid
Packaging
5g
Price
$60
Updated
2021/12/16
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4-Aminophthalic acid Chemical Properties,Usage,Production

Chemical Properties

Beige powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

610-27-5

5434-21-9

The general procedure for the synthesis of 4-amino phthalic acid from 4-nitrophthalic acid was as follows: 1 g (4.73 mmol) of 4-nitrophthalic acid was dissolved in 10 ml of anhydrous ethanol. The solution was stirred and degassed at room temperature and under argon protection. Subsequently, 50 mg of 5% palladium/carbon catalyst was added at once and hydrogen was passed into the solution for hydrogenation reaction. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated by evaporation to give an orange oily product with a mass of 820 mg and a yield of 96%. The structure of the product was confirmed by 1H NMR (DMSO-d6) with the following chemical shifts: 3.32 (1H, s), 5.95 (1H, s), 6.49-6.53 (2H, m), 7.46-7.50 (1H, d, J = 8.8 Hz), 12.33 (2H, COOH, s).

References

[1] Patent: US6689922, 2004, B1. Location in patent: Page column 20
[2] Patent: US6706725, 2004, B1. Location in patent: Page column 11
[3] Chemical Communications, 2017, vol. 53, # 62, p. 8751 - 8754
[4] Justus Liebigs Annalen der Chemie, 1881, vol. 208, p. 230
[5] Journal of the American Chemical Society, 1908, vol. 30, p. 1143

4-Aminophthalic acid Preparation Products And Raw materials

Raw materials

4-Nitrobenzoic acid

Preparation Products

Benzocaine Sulindac
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4-Aminophthalic acid Suppliers

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View Lastest Price from 4-Aminophthalic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Aminophthalic acid 5434-21-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-05
Asia Chem I and E (Jiangsu) Co Ltd
Product
4-Aminophthalic acid 5434-21-9
Price
US $167.44/Kg/Drum
Min. Order
25Kg/Drum
Purity
98.50%HPLC
Supply Ability
6tons/month
Release date
2021-09-23
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Pomalidomide Impurity 45 5434-21-9
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-27

5434-21-9, 4-Aminophthalic acidRelated Search:

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