ChemicalBook > CAS DataBase List > Bis(2-ethylhexyl) phthalate

Bis(2-ethylhexyl) phthalate

Product Name
Bis(2-ethylhexyl) phthalate
CAS No.
117-81-7
Chemical Name
Bis(2-ethylhexyl) phthalate
Synonyms
DOP;DEHP;Behp;daf68;DAF 68;di-sec;NLA-20;Octoil;mollano;Fleximel
CBNumber
CB8708555
Molecular Formula
C24H38O4
Formula Weight
390.56
MOL File
117-81-7.mol
More
Less

Bis(2-ethylhexyl) phthalate Property

Melting point:
-50 °C
Boiling point:
386 °C (lit.)
Density 
0.985 g/mL at 20 °C (lit.)
vapor density 
>16 (vs air)
vapor pressure 
1.2 mm Hg ( 93 °C)
refractive index 
n20/D 1.488
Flash point:
405 °F
storage temp. 
2-8°C
solubility 
Miscible with mineral oil and hexane (U.S. EPA, 1985)
form 
Liquid
color 
APHA: ≤10
Odor
Very slight, characteristic.
Water Solubility 
Negligible
FreezingPoint 
<-60℃
Merck 
14,2864
BRN 
1890696
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.1 at 25 °C (calculated, Howard, 1989)
Exposure limits
Potential occupational carcinogen. NIOSH REL: TWA 5, STEL 10, IDLH 5,000; OSHA PEL: TWA 5; ACGIH TLV: TWA 5 (adopted).
CAS DataBase Reference
117-81-7(CAS DataBase Reference)
IARC
2B (Vol. Sup 7, 77, 101) 2013
NIST Chemistry Reference
Bis(2-ethylhexyl)phthalate(117-81-7)
EPA Substance Registry System
Di(2-ethylhexyl) phthalate (117-81-7)
More
Less

Safety

Hazard Codes 
T,F
Risk Statements 
60-61-39/23/24/25-23/24/25-11
Safety Statements 
53-45-36/37-16
RIDADR 
UN 1230 3/PG 2
WGK Germany 
1
RTECS 
TI0350000
Autoignition Temperature
734 °F
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29173400
Hazardous Substances Data
117-81-7(Hazardous Substances Data)
Toxicity
Acute oral LD50 for guinea pigs 26 gm/kg, mice 30 gm/kg, rats 30,600 mg/kg, rabbits 34 gm/kg (quoted, RTECS, 1985).
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H360May damage fertility or the unborn child

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
47994
Product name
Bis(2-ethylhexyl) phthalate solution
Purity
certified reference material, 2000?μg/mL in methanol
Packaging
1 mL
Price
$35.7
Updated
2021/03/22
Sigma-Aldrich
Product number
36735
Product name
Bis(2-ethylhexyl) phthalate
Purity
PESTANAL , analytical standard
Packaging
1g
Price
$37.8
Updated
2021/03/22
Sigma-Aldrich
Product number
1545056
Product name
Plastic additive 14
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$366
Updated
2020/08/18
TCI Chemical
Product number
P0297
Product name
Bis(2-ethylhexyl) Phthalate
Purity
>98.0%(GC)
Packaging
25g
Price
$17
Updated
2021/03/22
TCI Chemical
Product number
P0297
Product name
Bis(2-ethylhexyl) Phthalate
Purity
>98.0%(GC)
Packaging
500g
Price
$22
Updated
2021/03/22
More
Less

Bis(2-ethylhexyl) phthalate Chemical Properties,Usage,Production

Chemical Properties

Bis(2-ethylhexyl)phthalate is a colorless liquid with a slight odor. It is miscible with mineral oil and hexane, and soluble in most organic solvents. Bis(2-ethylhexyl)phthalate is insoluble in water (NTP, 1994a).

Uses

Dialkyl phthalate ester plasticizer used to import softness and flexibility to PVC products.

Uses

As plasticizer in PVC applications and flexible vinyls.

Uses

Bis(2-ethylhexyl) phthalate is commonly used plasticizing agent for PVCs, which as such is a component of blood bank bags, surgical tubing, and other products including food wrappers and children’s toys.

Uses

Bis(2-ethylhexyl) phthalate, known by a variety of other names and usually abbreviated DEHP, was patented in 1950 and first used as vacuum pump oil. But since then, it has become the most widely used plasticizer for poly(vinyl chloride) (PVC) and other plastics. Recently, relatively high levels of DEHP have been found in foods, especially foods high in oils and fats. The U.S. Food and Drug Administration now restricts its use in packaging materials to water-based foods. The European Commission has banned the use of DEHP and other phthalates in PVC toys.
Di(2-ethylhexyl)phthalate (DEHP) is a benzenedicarboxilate ester which is the most widely used plasticizer to soften resins. DEHP is hydrolyzed into what many believe to be its toxic metabolite, mono(2-ethylhexyl)phthalate (MEHP), by lipase enzymes in the gastrointestinal tract.

Definition

ChEBI: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.

Production Methods

DEHP is commercially produced via esterification of phthalic acid anhydride and 2-ethylhexanol. Esterification is completed with an acid or metal catalyst or with no catalyst at high temperature.

General Description

Colorless to pale yellow oily liquid. Nearly odorless.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Bis(2-ethylhexyl) phthalate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. Incompatible with nitrates .

Health Hazard

Inhalation can cause nausea and irritation of nose and throat. Contact of liquid with eyes or skin causes irritation. Ingestion can cause abdominal cramps, nausea and diarrhea.

Health Hazard

The acute oral toxicity is of extremelylow order. The oral LD50 value in miceis in the range 30,000 mg/kg. Ingestion ofabout 10 mL of the liquid may produce gas trointestinal pain, hypermotility, and diar rhea in humans. Chronic administration byoral route did not produce any adverseeffect in animals. A dose of 100 mg/kg/dayproduced increased liver and kidney weight,as well as retardation of growth in dogs.Mice given diets containing 12,000 ppm ofdiethylhexyl phthalate for 40 weeks devel oped renal hyperplasia (Ward et al. 1988).There was no evidence of renal carcino genicity. Oral administration, however, pro duced tumors in livers in the laboratoryanimals. It is a suspected cancer-causingagent, and there is sufficient evidence of itscarcinogenicity in animals. Such evidence inhumans, however, is lacking
Rock and co-workers (1988) reported theinteraction of diethylhexyl phthalate withblood during storage in PVC plastic containers. The plasticizer is leached into theplasma and converted to mono(2-ethylhexyl)phthalate by a plasma enzyme. At a levelof >125 mg/mL in the blood mono(2-ethyl hexyl) phthalate produced a 50% decrease inheart rate and blood pressure in rats.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Experimental teratogenic data. Other experimental reproductive effects. Poison by intravenous route. Human systemic effects by ingestion: gastrointestinal tract effects. A mild skin and eye irritant. When heated to decomposition it emits acrid smoke.

Potential Exposure

Bis(2-ethylhexyl)phthalate is primarily used as one of several plasticizers in polyvinyl chloride resins used for fabricating flexible vinyl products. It has also been reported as being used as a replacement for polychlorinated biphenyls (PCBs) in dielectric fluids for electric capacitors and in vacuum pumps (NTP, 1994a; Merck, 1989). The primary stationary sources that have reported emissions of bis(2-ethylhexyl)phthalate in California are furniture and fixtures manufacturing, and lumber and wood products manufacturing (ARB, 1997b).

Carcinogenicity

Di(2-ethylhexyl) phthalate (DEHP) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Source

MCLG: zero; MCL: 6 μg/L. In addition, a DWEL of 700 μg/L was recommended (U.S. EPA, 2000).
Detected in distilled water-soluble fractions of new and used motor oil at concentrations of 17–21 and ND-1.2 μg/L, respectively (Chen et al., 1994). Also may leach from plastic products used in analytical laboratories (e.g., tubing, containers).

Environmental Fate

Biological. Bis(2-ethylhexyl) phthalate degraded in both amended and unamended calcareous soils from New Mexico. After 146 d, 76 to 93% degraded (mineralized) to carbon dioxide. No other metabolites were detected (Fairbanks et al., 1985). In a 56-d experiment, [14C]bis(2- ethylhexyl) phthalate applied to soil-water suspensions under aerobic and anaerobic conditions gave 14CO2 yields of 11.6 and 8.1%, respectively (Scheunert et al., 1987).
When bis(2-ethylhexyl) phthalate was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, no degradation was observed after 7 d. In a 21-d period, however, gradual adaptation did occur resulting in 95 and 93% losses at concentrations of 5 and 10 mg/L, respectively (Tabak et al., 1981).
Half-lives of 19 h and 4–5 wk were reported for bis(2-ethylhexyl) phthalate in activated sludge and river water, respectively (Saeger and Tucker, 1976). In sludge-amended agricultural soil, bis(2-ethylhexyl) phthalate (initial concentration 4.1 nmol/g) degraded at a rate of 25.6 pmol/g·day via the intermediate o-phthalic acid. Despite the presence of microorganisms capable of degrading bis(2-ethylhexyl) phthalate, >40% of the bis(2-ethylhexyl) phthalate added was not mineralized after 1 yr (Roslev et al., 1998). Aerobic degradation of bis(2-ethylhexyl) phthalate by acclimated soil and activated sewage sludge microbes was studied using an acclimated shake flask CO2 evolution test. After 28 d, loss of bis(2-ethylhexyl) phthalate (primary degradation) was >99%, with a lag phase of 2.7 d, and ultimate biodegradation (CO2 evolution) was 86%. The half-life under these conditions was 4.55 d (Sugatt et al., 1984).
In the presence of suspended natural populations from unpolluted aquatic systems, the secondorder microbial transformation rate constant determined in the laboratory was reported to be 4.2 ± 0.7 x 10-15 L/organism?h (Steen, 1991). Using the modified Sturm test, >80% of bis(2-ethylhexyl) phthalate mineralized to carbon dioxide in 28 d (Scholz et al., 1997).
Surface Water. In laboratory experiments, the extrapolated volatilization half-life of bis(2- ethylhexyl) phthalate in a stirred water vessel (outer dimensions 22 x 10 x 21 cm) conducted at 22 and 30 °C and an air flow rate of 0.20 m/sec is 3,500 h (Kl?pffer et al., 1982).
Photolytic. The estimated photolytic half-life of bis(2-ethylhexyl) phthalate in water is 143 d (Wolfe et al., 1980).
Chemical/Physical. Hydrolyzes in water to o-phthalic acid (via the intermediate 2-ethyl-hexyl hydrogen phthalate) and 2-ethylhexyl alcohol (Kollig, 1993; Wolfe et al., 1980). Although no pH value was given, the reported hydrolysis rate constant under alkaline conditions is 1,400/M?yr (Ellington et al., 1993; Kollig, 1993). A second-order rate constant of 1.1 x 10-4/M?sec was reported for the hydrolysis bis(2-ethylhexyl) phthalate at 30 °C and pH 8 (Wolfe et al., 1980). Kl?pffer et al. (1982) estimated an evaporation half-life of approximately 140 d from a 21-cm deep vessel.

Metabolism

Bis(2-ethylhexyl) phthalate is metabolized in fish by enzymatic hydrolysis to mono-2-ethylhexyl phthalate, phthalic acid, and glucuronides of these compounds (Stalling et al., 1973).

Purification Methods

Wash the ester with Na2CO3 solution, then shake it with water. After the resulting emulsion has been broken by adding ether, the ethereal solution is washed twice with water, dried (CaCl2), and evaporated. The residual liquid is distilled several times under reduced pressure, then stored in a vacuum desiccator over P2O5 [French & Singer J Chem Soc 1424 1956]. [Beilstein 9 IV 3184.]

More
Less

Bis(2-ethylhexyl) phthalate Suppliers

Ji' nan anying trading co., ltd
Tel
Email
wmc2020@qq.com
Country
China
ProdList
22
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Foshan Daping Chemical Technology Co., Ltd
Tel
0757-26601217-
Fax
0757-26601217
Email
dxp6878@163.com
Country
China
ProdList
28
Advantage
58
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-87576359- ;029-61856359- ;029-61856362-
Fax
029-88380327
Email
1018@dideu.com;1027@dideu.com;1028@dideu.com
Country
China
ProdList
2011
Advantage
58
Wuhan jiyesheng Chemical Co., Ltd
Fax
027-83325000
Email
2186555900@qq.com
Country
CHINA
ProdList
368
Advantage
58
Ji 'nan jinbang environmental protection technology co., ltd
Tel
; ;
Email
3306388863@qq.com;3306388863@qq.com;3306388863@qq.com
Country
China
ProdList
29
Advantage
58
-Wuhan unioncom Biotechnology Co., Ltd
Tel
Email
jyschemzh@qq.com
Country
China
ProdList
31
Advantage
58
Shandong kejian chemical co., ltd
Tel
Email
2967443613@qq.com
Country
China
ProdList
20
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
More
Less

View Lastest Price from Bis(2-ethylhexyl) phthalate manufacturers

Wuhan Mulei New Material Technology Co. Ltd
Product
Bis(2-ethylhexyl) phthalate 117-81-7
Price
US $10.00/KG/Tin
Min. Order
1KG
Purity
99%
Supply Ability
5000tons per month
Release date
2021-04-06
Wuhan wingroup Pharmaceutical Co., Ltd
Product
Bis(2-ethylhexyl) phthalate 117-81-7
Price
US $1.00/g
Min. Order
1KG
Purity
99%
Supply Ability
30 Tons
Release date
2021-06-29
Wuhan Monad Medicine Tech Co.,LTD
Product
bis(2-ethylhexyl) phthalate 117-81-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99%
Supply Ability
200 tons/month
Release date
2020-12-30

117-81-7, Bis(2-ethylhexyl) phthalateRelated Search:


  • 1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester
  • 1,2-Benzenedicarboxylic acid, bis(ethylhexyl) ester
  • 1,2-benzenedicarboxylicacid,bis(2-ethylhexyl)ester
  • 1,2-benzenedicarboxylicacid,bis(ethylhexyl)ester
  • Di(2-ethylhexyl) Phthalate Dioctyl Phthalate Phthalic Acid Bis(2-ethylhexyl) Ester Phthalic Acid Di(2-ethylhexyl) Ester Phthalic Acid Dioctyl Ester DEHP DOP
  • Bis(2-ethylhexyl)ester phthalic acid
  • bis-(2-ethylhexyl)esterkyselinyftalove
  • Bis(ethylhexyl) phthalate
  • Bisoflex 81
  • Bisoflex 82
  • Bisoflex DOP
  • bisoflex81
  • bisoflexdop
  • Compound 889
  • compound889
  • DAF 68
  • daf68
  • DEHP
  • dehp(1,2-benzenedicarboxylicacid,bis(2-ethylhexyl)ester)
  • di(.alpha.-Ethylhexyl)phthalate
  • di(2-ethylhexyl)
  • Di(2-ethylhexyl) o-phthalate
  • Di(2-ethylhexyl)orthophthalate
  • Di(2-ethylhexyl)phthalat
  • Di(ethylhexyl) phthalate
  • di(ethylhexyl)phthalate
  • di-2-ethylhexylphthalate(dehp)
  • diethylhexylphthalate
  • Dioctyl phthalate1,2-benzenedicarboxylic acid bis(2-ethylhexyl) ester
  • di-sec
  • dof(russianplasticizer)
  • Ergoplast fdo
  • Ergoplast FDO-S
  • ergoplastfdo
  • ergoplastfdo-s
  • Ethylhexyl Phthalate
  • ethylhexylphthalate
  • Eviplast 80
  • Eviplast 81
  • eviplast80
  • eviplast81
  • Fleximel
  • Flexol DOP
  • Flexol plasticizer DOP
  • flexoldop
  • flexolplasticizerdop
  • Good-rite gp 264
  • good-ritegp264
  • Hatcol dop
  • hatcoldop
  • Hercoflex 260
  • hercoflex260
  • jayflexdop
  • Kodaflex DOP
  • Kodaflex DP
  • kodaflexdop
  • Merrol DOP
  • Mollan O