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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

Product Name
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
CAS No.
155377-19-8
Chemical Name
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
Synonyms
ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE;BUTTPARK 29\06-81;Ethyl 3-(trifluoromethyl)pyrazole-4-c;ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-;ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE;Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate97%;Ethyl3-(Trifluoromethyl)pyrazole-4-carboxylate>Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate 97%;Ethyl 3-(trifluoromethyl)-2H-pyrazole-4-carboxylate;Ethyl3-trifluoromethyl-1H-pyrazole-4-carboxylate,97%
CBNumber
CB6254184
Molecular Formula
C7H7F3N2O2
Formula Weight
208.14
MOL File
155377-19-8.mol
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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Property

Melting point:
145 °C
Boiling point:
301.3±42.0 °C(Predicted)
Density 
1.397±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
8.26±0.50(Predicted)
color 
White to Light yellow
CAS DataBase Reference
155377-19-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681873
Product name
Ethyl 3- (trifluoromethyl)-1H-pyrazole-4-carboxylate
Purity
97%
Packaging
5g
Price
$123
Updated
2022/05/15
TCI Chemical
Product number
E1024
Product name
Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
Purity
>98.0%(GC)
Packaging
1g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
E1024
Product name
Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
Purity
>98.0%(GC)
Packaging
5g
Price
$205
Updated
2025/07/31
TRC
Product number
E931250
Product name
Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
Packaging
10g
Price
$330
Updated
2021/12/16
Matrix Scientific
Product number
006377
Product name
Ethyl 5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Purity
97%
Packaging
1g
Price
$21
Updated
2021/12/16
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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White to tan powder

Uses

Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate (cas# 155377-19-8) is a compound useful in organic synthesis.

Synthesis

571-55-1

155377-19-8

The general procedure for the synthesis of ethyl 3-trifluoromethylpyrazole-4-carboxylate from ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate was as follows: hydrazine hydrate (10 g, 0.199 mol) was dissolved in ethanol (400 mL) and the solution was cooled to 0 °C. A solution of ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate (47.03 g, 0.19 mol) in ethanol (200 mL) was added dropwise to this cooled solution over 90 min. The reaction mixture was kept at 0 °C. Subsequently, the reaction solution was slowly warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, the mixture was concentrated to dryness. The resulting residue was dispersed in boiling cyclohexane (200 mL) and then cooled to room temperature. The precipitate was collected by filtration and washed with cyclohexane. Finally, the product was dried under vacuum at 75 °C to afford ethyl 3-trifluoromethylpyrazole-4-carboxylate (compound 3f) as a yellow powder (38.67 g, 95% yield). The melting point of the product was 145 °C. 1H NMR (CDCl3) data: δ 1.40 (t, 3H, J = 7.0 Hz), 4.39 (q, 2H, J = 7.0 Hz), 8.26 (s, 1H), 13.2 (s (br), 1H). 13C NMR (CDCl3) data: δ 14.0, 61.2, 113.4, 121.0 ( q, J = 268 Hz), 135.3, 142.0 (q, J = 38 Hz), 160.8. High-resolution mass spectrometry (HRMS) analysis: calculated value of 207.0381 for C7H7F3N2O2-H; measured value of 207.0377.

References

[1] Tetrahedron, 2011, vol. 67, # 44, p. 8451 - 8457
[2] Patent: WO2016/81918, 2016, A1. Location in patent: Paragraph 00279
[3] Patent: WO2016/151403, 2016, A1. Location in patent: Paragraph 00521
[4] Patent: WO2017/205684, 2017, A1. Location in patent: Paragraph 00692; 00693
[5] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 47 - 56

ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Acetic anhydride Triethyl orthoformate Hydrazine dihydrochloride

Preparation Products

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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Suppliers

Americas 1 Belgium 2 Canada 1 China 149 Europe 1 France 1 Germany 2 India 8 Japan 1 Switzerland 1 United Kingdom 10 United States 20 Global 197
Creasyn Finechem(Tianjin) Co., Ltd.
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View Lastest Price from ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate 155377-19-8
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Career Henan Chemical Co
Product
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 155377-19-8
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

155377-19-8, ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATERelated Search:

ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-(4-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 3-(Trifluoromethyl)pyrazole Ethyl pyrazole-4-carboxylate ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-PHENYL-1,3-THIAZOL-2-YL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Ethyl 2-methyl-3-(trifluoromethyl)pyrazole-4-carboxylate ,97% ETHYL 1-(5-ACETYL-4-METHYL-1,3-THIAZOL-2-YL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-[(2-CHLOROACETYL)AMINO]PHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-[5-[(4-CHLOROPHENYL)SULFANYL]-4-(2,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-[4-(4-METHOXYPHENYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(2,3,3-TRICHLOROACRYLOYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-(4-AMINO-PHENYL)-5-TRIFLUOROMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 1-[4-(4-NITROPHENYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

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