ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

Product Name: ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
CAS No.: 111493-74-4
Chemical Name: ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
Synonyms: BUTTPARK 82\18-63;Ethyl 1-methyl-3-(trifluoromethyl)pyrazole-4-;Ethyl 1-methyl-3-trifluoromethyl-4-pyrazolecarboxylate;ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE;1-methyl-3-trifluoromethyl-1H-pyrazole-4-ethyl carboxylate;4-(Ethoxycarbonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole;Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-carboxylate;ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE;Ethyl-5-(trifluoroMethyl)-1-Methyl-1h-pyrazole-4-carboxylate;Ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
CBNumber: CB6280468
Molecular Formula: C8H9F3N2O2
Formula Weight: 222.16
MOL File: 111493-74-4.mol

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ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Property

Melting point:: 60-61°C
Boiling point:: 267.4±40.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -2.85±0.10(Predicted)
form: solid
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C8H9F3N2O2/c1-3-15-7(14)5-4-13(2)12-6(5)8(9,10)11/h4H,3H2,1-2H3
InChIKey: ZZEXDJGNURSJOF-UHFFFAOYSA-N
SMILES: N1(C)C=C(C(OCC)=O)C(C(F)(F)F)=N1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0014
Product name: Ethyl 5-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $216
Updated: 2025/07/31

AK Scientific

Product number: X8976
Product name: Ethyl1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Packaging: 1g
Price: $77
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: CAPOM11115
Product name: Ethyl1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Purity: 98%
Packaging: 5g
Price: $119
Updated: 2021/12/16

Apolloscientific

Product number: PC10137
Product name: Ethyl1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Packaging: 5g
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 043005
Product name: Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Purity: >95%
Packaging: 1g
Price: $24
Updated: 2021/12/16

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ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

74-88-4

155377-19-8

111493-74-4

Ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate (2.0 g, 9.61 mmol) was dissolved in N,N-dimethylformamide (20 mL) and the solution was cooled to 0 °C. Sodium hydride (0.58 g, 14.42 mmol, 60% dispersed in mineral oil) was slowly added to the solution at 0 °C and the reaction mixture was stirred for 20 min. Subsequently, iodomethane (0.90 mL, 14.42 mmol) was added and the reaction mixture was gradually warmed to room temperature over 18 hours. Upon completion of the reaction, the mixture was partitioned between ethyl acetate (100 mL) and water (50 mL). The organic layer was separated and washed sequentially with water (5 x 50 mL) and saturated aqueous sodium chloride solution (50 mL). The organic layer was dried with anhydrous sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (eluent: 90:10 hexane/ethyl acetate) to afford ethyl 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylate (1.74 g, 81.7% yield).1H-NMR (400 MHz, CDCl3) δ 7.92 (s, 1H), 4.27 (q, 2H ), 3.95 (s, 3H), 1.33 (t, 3H).

References

[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 16, p. 4569 - 4574
[2] Angew. Chem., 2017, vol. 129, # 16, p. 4640 - 4645,6
[3] Patent: WO2008/141020, 2008, A1. Location in patent: Page/Page column 50
[4] Molecules, 2012, vol. 17, # 12, p. 14205 - 14218

ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethyl vinyl ether Hexane tert-Butyllithium Ethanol Sodium thiosulfate Trifluoroacetic acid Carbon dioxide Pentane Tetrahydrofuran Diethyl ether Bromine Methylhydrazine Methanol Iron Thionyl chloride 4-Dimethylaminopyridine

Preparation Products

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ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Suppliers

China 92 Germany 1 India 2 United Kingdom 7 United States 17 Global 119

Nanjing YiFan Biological Technology Co., Ltd.

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Pure Chemistry Scientific Inc.

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View Lastest Price from ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 111493-74-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

Career Henan Chemical Co

Product: ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 111493-74-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

111493-74-4, ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATERelated Search:

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 3-(Trifluoromethyl)pyrazole RARECHEM AL BI 1018 ETHYL 1-(2,3,3-TRICHLOROACRYLOYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE RARECHEM AL BI 1289 RARECHEM AL BI 0329 RARECHEM AL BI 1069 RARECHEM AL BI 1285 RARECHEM AL BI 1288 RARECHEM AL BI 1021 RARECHEM AL BI 1068 RARECHEM AL BI 1020 RARECHEM AL BI 1017 RARECHEM AL BI 1287 RARECHEM AL BI 1019 RARECHEM AL BI 1286

Ethyl 1-methyl-3-(trifluoromethyl)pyrazole-4-

Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate ,95%

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ethyl ester

ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

BUTTPARK 82\18-63

4-(Ethoxycarbonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole

Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate ,97%

JR-13907, Ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, 96%

Ethyl-5-(trifluoroMethyl)-1-Methyl-1h-pyrazole-4-carboxylate

1-Methyl-3-trifluoromethylpyrazole-4-carboxylic acid ethyl ester

Ethyl 1-methyl-3-trifluoromethyl-4-pyrazolecarboxylate

Ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

1H-Pyrazole-4-carboxylic acid, 1-methyl-3-(trifluoromethyl)-, ethyl ester

Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-carboxylate

1-methyl-3-trifluoromethyl-1H-pyrazole-4-ethyl carboxylate

111493-74-4

C8H9F3N2O2

C8H11F3N2O2

Building Blocks

Pyrazole