ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
- CAS No.
- 111493-74-4
- Chemical Name
- ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Synonyms
- BUTTPARK 82\18-63;Ethyl 1-methyl-3-(trifluoromethyl)pyrazole-4-;Ethyl 1-methyl-3-trifluoromethyl-4-pyrazolecarboxylate;ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE;1-methyl-3-trifluoromethyl-1H-pyrazole-4-ethyl carboxylate;4-(Ethoxycarbonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole;Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-carboxylate;ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE;Ethyl-5-(trifluoroMethyl)-1-Methyl-1h-pyrazole-4-carboxylate;Ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
- CBNumber
- CB6280468
- Molecular Formula
- C8H9F3N2O2
- Formula Weight
- 222.16
- MOL File
- 111493-74-4.mol
ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Property
- Melting point:
- 60-61°C
- Boiling point:
- 267.4±40.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -2.85±0.10(Predicted)
- form
- solid
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C8H9F3N2O2/c1-3-15-7(14)5-4-13(2)12-6(5)8(9,10)11/h4H,3H2,1-2H3
- InChIKey
- ZZEXDJGNURSJOF-UHFFFAOYSA-N
- SMILES
- N1(C)C=C(C(OCC)=O)C(C(F)(F)F)=N1
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- JRD0014
- Product name
- Ethyl 5-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- 043005
- Product name
- Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 043005
- Product name
- Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- CAPOM11115
- Product name
- Ethyl1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 043005
- Product name
- Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
74-88-4
155377-19-8
111493-74-4
Ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate (2.0 g, 9.61 mmol) was dissolved in N,N-dimethylformamide (20 mL) and the solution was cooled to 0 °C. Sodium hydride (0.58 g, 14.42 mmol, 60% dispersed in mineral oil) was slowly added to the solution at 0 °C and the reaction mixture was stirred for 20 min. Subsequently, iodomethane (0.90 mL, 14.42 mmol) was added and the reaction mixture was gradually warmed to room temperature over 18 hours. Upon completion of the reaction, the mixture was partitioned between ethyl acetate (100 mL) and water (50 mL). The organic layer was separated and washed sequentially with water (5 x 50 mL) and saturated aqueous sodium chloride solution (50 mL). The organic layer was dried with anhydrous sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (eluent: 90:10 hexane/ethyl acetate) to afford ethyl 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylate (1.74 g, 81.7% yield).1H-NMR (400 MHz, CDCl3) δ 7.92 (s, 1H), 4.27 (q, 2H ), 3.95 (s, 3H), 1.33 (t, 3H).
References
[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 16, p. 4569 - 4574
[2] Angew. Chem., 2017, vol. 129, # 16, p. 4640 - 4645,6
[3] Patent: WO2008/141020, 2008, A1. Location in patent: Page/Page column 50
[4] Molecules, 2012, vol. 17, # 12, p. 14205 - 14218
ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE Suppliers
- Tel
- --
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- info@abcr.de
- Country
- Germany
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View Lastest Price from ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE manufacturers
- Product
- ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 111493-74-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22
- Product
- ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 111493-74-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23