ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
- CAS No.
- 155377-19-8
- Chemical Name
- ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
- Synonyms
- ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE;BUTTPARK 29\06-81;Ethyl 3-(trifluoromethyl)pyrazole-4-c;ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-;ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE;Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate97%;Ethyl3-(Trifluoromethyl)pyrazole-4-carboxylate>Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate 97%;Ethyl 3-(trifluoromethyl)-2H-pyrazole-4-carboxylate;Ethyl3-trifluoromethyl-1H-pyrazole-4-carboxylate,97%
- CBNumber
- CB6254184
- Molecular Formula
- C7H7F3N2O2
- Formula Weight
- 208.14
- MOL File
- 155377-19-8.mol
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Property
- Melting point:
- 145 °C
- Boiling point:
- 301.3±42.0 °C(Predicted)
- Density
- 1.397±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 8.26±0.50(Predicted)
- color
- White to Light yellow
- CAS DataBase Reference
- 155377-19-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29331990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 681873
- Product name
- Ethyl 3- (trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $123
- Updated
- 2022/05/15
- Product number
- E1024
- Product name
- Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- E1024
- Product name
- Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $205
- Updated
- 2025/07/31
- Product number
- E931250
- Product name
- Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
- Packaging
- 10g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 4H58-3-34
- Product name
- Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $456
- Updated
- 2021/12/16
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White to tan powder
Uses
Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate (cas# 155377-19-8) is a compound useful in organic synthesis.
Synthesis
571-55-1
155377-19-8
The general procedure for the synthesis of ethyl 3-trifluoromethylpyrazole-4-carboxylate from ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate was as follows: hydrazine hydrate (10 g, 0.199 mol) was dissolved in ethanol (400 mL) and the solution was cooled to 0 °C. A solution of ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate (47.03 g, 0.19 mol) in ethanol (200 mL) was added dropwise to this cooled solution over 90 min. The reaction mixture was kept at 0 °C. Subsequently, the reaction solution was slowly warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, the mixture was concentrated to dryness. The resulting residue was dispersed in boiling cyclohexane (200 mL) and then cooled to room temperature. The precipitate was collected by filtration and washed with cyclohexane. Finally, the product was dried under vacuum at 75 °C to afford ethyl 3-trifluoromethylpyrazole-4-carboxylate (compound 3f) as a yellow powder (38.67 g, 95% yield). The melting point of the product was 145 °C. 1H NMR (CDCl3) data: δ 1.40 (t, 3H, J = 7.0 Hz), 4.39 (q, 2H, J = 7.0 Hz), 8.26 (s, 1H), 13.2 (s (br), 1H). 13C NMR (CDCl3) data: δ 14.0, 61.2, 113.4, 121.0 ( q, J = 268 Hz), 135.3, 142.0 (q, J = 38 Hz), 160.8. High-resolution mass spectrometry (HRMS) analysis: calculated value of 207.0381 for C7H7F3N2O2-H; measured value of 207.0377.
References
[1] Tetrahedron, 2011, vol. 67, # 44, p. 8451 - 8457
[2] Patent: WO2016/81918, 2016, A1. Location in patent: Paragraph 00279
[3] Patent: WO2016/151403, 2016, A1. Location in patent: Paragraph 00521
[4] Patent: WO2017/205684, 2017, A1. Location in patent: Paragraph 00692; 00693
[5] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 47 - 56
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE manufacturers
- Product
- Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate 155377-19-8
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 155377-19-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23