Ethyl 4,4,4-trifluoroacetoacetate

Product Name: Ethyl 4,4,4-trifluoroacetoacetate
CAS No.: 372-31-6
Chemical Name: Ethyl 4,4,4-trifluoroacetoacetate
Synonyms: ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE;ETHYL TRIFLUOROACETOACETATE;ETFAA;4,4,4-trifL;AKOS B020306;uoroacetoacetate;TIMTEC-BB SBB008825;Ethyl 4,4,4-trifluor;Trifluoroacylacidester;4-trifluoroacetoacetate
CBNumber: CB1133091
Molecular Formula: C6H7F3O3
Formula Weight: 184.11
MOL File: 372-31-6.mol

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Ethyl 4,4,4-trifluoroacetoacetate Property

Melting point:: -39 °C
Boiling point:: 129-130 °C(lit.)
Density: 1.259 g/mL at 25 °C(lit.)
vapor pressure: 8hPa at 20℃
refractive index: n20/D 1.375(lit.)
Flash point:: 84 °F
storage temp.: Sealed in dry,Room Temperature
solubility: 10g/l
form: Liquid
pka: 7.76±0.10(Predicted)
color: Clear colorless to slightly yellow
Specific Gravity: 1.259 (20/4℃)
PH: 6.2 (10g/l, H2O, 20℃)
Water Solubility: 10 g/L (20 ºC)
BRN: 608353
InChIKey: OCJKUQIPRNZDTK-UHFFFAOYSA-N
CAS DataBase Reference: 372-31-6(CAS DataBase Reference)
NIST Chemistry Reference: Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6)
EPA Substance Registry System: Ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

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Safety

Hazard Codes: Xn,F,C,Xi
Risk Statements: 10-22-52/53
Safety Statements: 61-16
RIDADR: UN 3272 3/PG 3
WGK Germany: 2
Hazard Note: Flammable/Corrosive
TSCA: TSCA listed
HazardClass: 3
PackingGroup: III
HS Code: 29183000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T0810
Product name: Ethyl 4,4,4-Trifluoroacetoacetate
Purity: >98.0%(GC)
Packaging: 25g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: T0810
Product name: Ethyl 4,4,4-Trifluoroacetoacetate
Purity: >98.0%(GC)
Packaging: 100g
Price: $195
Updated: 2025/07/31

Sigma-Aldrich

Product number: E50205
Product name: Ethyl 4,4,4-trifluoroacetoacetate
Purity: 99%
Packaging: 5g
Price: $33.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: E50205
Product name: Ethyl 4,4,4-trifluoroacetoacetate
Purity: 99%
Packaging: 25g
Price: $55.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: E50205
Product name: Ethyl 4,4,4-trifluoroacetoacetate
Purity: 99%
Packaging: 100g
Price: $116
Updated: 2025/07/31

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Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties,Usage,Production

Chemical Properties

Clear liquid

Uses

Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet

Uses

Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Flammability and Explosibility

Flammable

Synthesis

With an ethanol solution of sodium ethoxide as a catalyst and in the presence of an organic solvent, ethyl trifluoroacetate and ethyl acetate are subjected to a Claisen condensation reaction, and ethyl 4,4,4-trifluoroacetoacetate is synthesized.

References

[1] Journal of Fluorine Chemistry, 1982, vol. 20, p. 187
[2] Patent: CN103214355, 2016, B. Location in patent: Paragraph 0076
[3] Bulletin des Societes Chimiques Belges, 1926, vol. 35, p. 414
[4] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1926, vol. <5> 12, p. 680,692
[5] Chem. Zentralbl., 1927, vol. 98, # I, p. 996,1286

Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid

Preparation Products

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 2-Hydroxy-4-(trifluoromethyl)quinoline (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE THIFLUZAMIDE Ethyl 3-amino-4,4,4-trifluorocrotonate 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE 4-Methylpyrimidine 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97% Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% Coumarin 151 ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline 6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97% 4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-bromo-2-(trifluoromethyl)quinoline 4-(Trifluoromethyl)quinolin-2-amine 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone 4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE 2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

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Ethyl 4,4,4-trifluoroacetoacetate Suppliers

Belgium 2 Canada 1 China 467 Europe 3 France 1 Germany 8 India 15 Ireland 1 Italy 1 Japan 5 Russia 1 Slovakia 1 Sweden 1 Switzerland 5 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 50 Global 583

Jinan Wanxingda Chemical Co., Ltd.

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Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd

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View Lastest Price from Ethyl 4,4,4-trifluoroacetoacetate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 4,4,4-trifluoroacetoacetate 372-31-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-06-30

Chongqing Soarwin Technology Co., Ltd

Product: Ethyl 4,4,4-trifluoroacetoacetate 372-31-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-15

Qingdao RENAS Polymer Material Co., Ltd.

Product: ethyl 4,4,4-trifluoroacetoacetate 372-31-6
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-08-26

372-31-6, Ethyl 4,4,4-trifluoroacetoacetateRelated Search:

Ethyl acetoacetate Ethyl 2-chloroacetoacetate Ethylparaben Methyl acetoacetate Ethyl formate Ethyl bromodifluoroacetate Ethanol Acetoxyacetic acid Ethyl cellulose Ethyl trifluoroacetate Ethyl 4-chloroacetoacetate Ethyl 4-bromoacetoacetate CHLOROETHANE Ethylbenzene Ethyl acetate Ethyl acrylate Ethyl 2-methylacetoacetate tert-Butyl acetoacetate Ethyl Trifluoroacetoacetate

Ethyl4,4,-Trifluoroacetoacetate

Ethyltrifluoroacetoacetate,98+%

ETHYL 4,4,4-TRIFLUOROACETYLACETATE

ETFAA

1-Ethoxy-4,4,4-trifluorobutane-1,3-dione

Ethyl 3-oxo-4,4,4-trifluorobutanoate

Ethyl 4,4,4-trifluoro-3-oxobutyrate

(Trifluoroacetyl)acetic acid ethyl ester

2-(Trifluoroacetyl)acetic acid ethyl ester

3-Oxo-4,4,4-trifluorobutanoic acid ethyl ester

4,4,4-Trifluoro-3-oxobutyric acid ethyl ester

Trifluoroacetylacetic acid ethyl ester

Ethyl 4,4,4-trifluoroacetoacetate 98%

Ethyl4,4,4-trifluoroacetoacetate98%

Ethyl 4,4,4-trifluoroacetoacetate,Ethyl 3-oxo-4,4,4-trifluorobutyrate

Ethyl 4,4,4-trifluoro-3-oxobutanoate, 97%+

Ethyl 4,4,4-trifluoro-3-oxobutanoate, 95%+

ETHYL TRIFLUOROACETOACETATE 98%

Ethyl 4,4,4-trifluoroacetoacetate,97%

Ethyl 2-(trifluoroacethyl)acetate

1-Ethoxy-4,4,4-trifluorobutane

ETHYL 3-OXO-4,4,4-TRIFLUOROACETOACETATE

ETHYL 3-OXO,4,4,4-TRIFLUOROBUTYRATE

ETHYL 4,4,4-TRIFLUOROACETOACETATE

ETHYL 4,4,4-TRIFLUOROACETOACTATE

ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE

ETHYL TRIFLUOROACETOACETATE

TIMTEC-BB SBB008825

4,4,4-TRIFLUORO-3-OXOBUTANOIC ACID ETHYL ESTER

4,4,4-TRIFLUOROACETOACETIC ACID ETHYL ESTER

AKOS B020306

4,4,4-trifluoro-3-oxo-butanoicaciethylester

Acetoacetic acid, 4,4,4-trifluoro-, ethyl ester

Acetoacetic acid, 4-trifluoro-, ethyl ester

Butanoicacid,4,4,4-trifluoro-3-oxo-,ethylester

Ethyl (trifluoroacetyl)acetate

Ethyl gamma,gamma,gamma-trifluoroacetoacetate

Ethyl omega,omega,omega-trifluoroacetoacetate

Ethyl 4,4,4-trifluor

TRIFLUOROACETOACETIC ACID ETHYL ESTER

Ethyl 4,4,4-trifluoroacetocaetate

Ethyl 4,4,4-trifluoroaceto

4,4,4- threefluorideethyl acetoacetate

Trifluoro ethyl acetoacetate

4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (Ethyl trifluoroacetoacetate)

Ethyl 4,4,4-trifluoro-3-oxobutanoate, Ethyl 4,4,4-trifluoro-3-oxobutyrate

Ethyl 3-oxo-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-oxobutanoate 4,4,4-Trifluoroacetoacetic Acid Ethyl Ester

4-trifluoroacetoacetate

Ethyl4,4,4-trifluoroacetoacetate (ETFAA)

4,4,4-trifL

uoroacetoacetate

Ethyl 4,4,4-trifluoroacetoa

Ethyl-4,4,4-trifluoracetoacetat

4,4,4-Ethyl trifluoroacetyl acetate

Ethyl 4,4,4-trifluoroacetoacetate?New

Ethyl4,4,4-Triflouroacetoacetate

Trifluoroacylacidester

372-31-6