7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

Product Name: 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
CAS No.: 575-03-1
Chemical Name: 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
Synonyms: 7-HYDROXY-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;TFMU;BUTTPARK 20\02-70;TFMU, Coumarin 174;TIMTEC-BB SBB006559;TRIFLUOROMETHYLUMBELLIFERONE;4-(TRIFLUOROMETHYL)UMBELLIFERON;4-(TRIFLUOROMETHYL)UMBELLIFERONE;BETA-TRIFLUOROMETHYLUMBELLIFERONE;Trifluoromethylumbelliferone(TFMU)
CBNumber: CB1102257
Molecular Formula: C10H5F3O3
Formula Weight: 230.14
MOL File: 575-03-1.mol

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7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN Property

Melting point:: 178-180 °C (lit.)
Boiling point:: 311.4±42.0 °C(Predicted)
Density: 1.4435 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMF: soluble
form: powder to crystal
pka: 7.23±0.20(Predicted)
color: White to Light yellow to Light orange
λmax: 330nm(Toluene)(lit.)
BRN: 210932
InChI: InChI=1S/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H
InChIKey: CCKWMCUOHJAVOL-UHFFFAOYSA-N
SMILES: C1(=O)OC2=CC(O)=CC=C2C(C(F)(F)F)=C1
CAS DataBase Reference: 575-03-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-25
Safety Statements: 26-36-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
F: 8-10
HazardClass: IRRITANT
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 368512
Product name: 7-Hydroxy-4-(trifluoromethyl)coumarin
Purity: 98%
Packaging: 250mg
Price: $53.7
Updated: 2023/01/07

Sigma-Aldrich

Product number: 368512
Product name: 7-Hydroxy-4-(trifluoromethyl)coumarin
Purity: 98%
Packaging: 1g
Price: $108
Updated: 2023/01/07

TCI Chemical

Product number: H1422
Product name: 7-Hydroxy-4-(trifluoromethyl)coumarin
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: H1422
Product name: 7-Hydroxy-4-(trifluoromethyl)coumarin
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $342
Updated: 2025/07/31

TRC

Product number: H971550
Product name: 7-Hydroxy-4-(trifluoromethyl)coumarin
Packaging: 2.5g
Price: $145
Updated: 2021/12/16

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7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN Chemical Properties,Usage,Production

Description

7-Hydroxy-4-(trifluoromethyl)coumarin can be used as a reference standard for fluorescent pH indicator.

Chemical Properties

Off-white to light yellow or pink powder

Uses

Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.

Uses

7-Hydroxy-4-(trifluoromethyl)coumarin is an halogenated metabolite of Coumarin (C755380), an naturally occurring organic compound that exists in many plants. Coumarin is the precursor molecule in the synthesis of various synthetic anti-coagulant such as warfarin (W498500)/.

General Description

7-Hydroxy-4-(trifluoromethyl)coumarin is a class of 7-hydroxycoumarin that is majorly used as laser dyes. It has a characterized emission spectra and may be used in excited state proton transfer (ESPT).

Synthesis

372-31-6

108-46-3

575-03-1

GENERAL METHOD: Iodine (25 mol%) was added to a mixture of resorcinol (5 mmol) and ethyl 4,4,4-trifluoroacetoacetate (6 mmol) in toluene (1 mL). The reaction mixture was heated and stirred at 90 °C for 18 h. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (10 mL) and washed with distilled water (10 mL). The combined organic layers were dried with anhydrous sodium sulfate and the solvent was removed by evaporation under reduced pressure. The product was purified by fast column chromatography (silica gel, eluent: hexane/ethyl acetate = 95/5 to 80/20).

References

[1] Synthetic Communications, 2006, vol. 36, # 20, p. 2949 - 2956
[2] Monatshefte fur Chemie, 2013, vol. 144, # 3, p. 411 - 414
[3] Tetrahedron Letters, 2002, vol. 43, # 50, p. 9195 - 9197
[4] Synthetic Communications, 2004, vol. 34, # 21, p. 3997 - 4003
[5] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6715 - 6717

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Sodium sulfate Toluene Resorcinol Iodine Ethyl acetate

Preparation Products

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7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN Suppliers

Americas 1 Belgium 2 Canada 1 China 139 Europe 1 France 1 Germany 3 India 12 Japan 2 Switzerland 3 United Kingdom 16 United States 32 Global 213

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View Lastest Price from 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN manufacturers

Dideu Industries Group Limited

Product: 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN 575-03-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN 575-03-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN 575-03-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-09

575-03-1, 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARINRelated Search:

Dimethyl sulfate 6,7-DIMETHOXY-4-(TRIFLUOROMETHYL)COUMARIN 4-(TRIFLUOROMETHYL)UMBELLIFERYL-BETA-D-GALACTOPYRANOSIDE 6,7-Diethoxy-4-(trifluoromethyl)coumarin 4-(TRIFLUOROMETHYL)UMBELLIFERYL BUTYRATE 4-TRIFLUOROMETHYLUMBELLIFERYL-A-D-N-ACETYLNEURAMINIC ACID 4-(TRIFLUOROMETHYL)UMBELLIFERYL-BETA-D-GLUCOPYRANOSIDE 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN 7-BENZYLOXY-4-(TRIFLUOROMETHYL)COUMARIN 4-(TRIFLUOROMETHYL)UMBELLIFERYL OLEATE 4-(TRIFLUOROMETHYL)UMBELLIFERYL ACETATE 6,7-DIHYDROXY-4-(TRIFLUOROMETHYL)COUMARIN 7-ETHOXY-4-(TRIFLUOROMETHYL)COUMARIN 6-CHLORO-7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN,6-chloro-7-hydroxy-4-(trifluoromethyl)coumarin 97%,6-chloro-7-hydroxy-4-(trifluoromethyl)coumarin97% 4-TRIFLUOROMETHYL-7-HYDROXYCOUMARIN GLUCURONIDE POTASSIUM SALT 7-METHOXY-4-(TRIFLUOROMETHYL)COUMARIN

TIMTEC-BB SBB006559

TFMU

TRIFLUOROMETHYLUMBELLIFERONE

7-HYDROXY-4-TRIFLUOROMETHYL-CHROMEN-2-ONE

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

7-HYDROXY-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE

4-(TRIFLUOROMETHYL)UMBELLIFERON

4-(TRIFLUOROMETHYL)UMBELLIFERONE

Trifluoromethylumbelliferone(TFMU)

7-Hydroxy-4-(trifluoromethyl)coumarin 97%

BUTTPARK 20\02-70

BETA-TRIFLUOROMETHYLUMBELLIFERONE

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN, 9 8%

4-(TRIFLUOROMETHYL)UMBELLIFERONE, FOR FL UORESCENCE

7-Hydroxy-4-(trifluoromethyl)coumarin97%

7-HYDROXY-4-(TRIFLOROMETHYL)COUMARIN

7-Hydroxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one

TFMU, Coumarin 174

7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one, 4-(Trifluoromethyl)umbelliferone

Beta-trifluoromethylumbelliferone [7-Hydroxy-4-trifluoromethylcoumarin] *CAS 575-03-1*

7-Hydroxy-4-(trifluoromethyl)coumarin&gt

2H-1-Benzopyran-2-one, 7-hydroxy-4-(trifluoromethyl)-

4-(Trifluoromethyl)-7-hydroxycoumarin

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN ISO 9001：2015 REACH

Beta-trifluoromethylumbelliferone [7-Hydroxy-4-trifluoromethylcoumarin]

575-03-1

C10H5F3O3

Biochemicals and Reagents

BioChemical

Fluorescent Probes, Labels, Particles and Stains

Detection

Biochemicals and Reagents

Detection

Fluorescent Probes, Labels, Particles and Stains

Coumarins

Coumarin

API intermediates