Ethyl 3-amino-4,4,4-trifluorocrotonate

Product Name: Ethyl 3-amino-4,4,4-trifluorocrotonate
CAS No.: 372-29-2
Chemical Name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Synonyms: Ethyl 3-amino-4;4-trifluorocrotonate;Ethyl 3-amino-4,4,4-trifluorocrotote;ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE;ethyl 3-amino-4,4,4-trifluro crotonate;Ethyl3-amino-4,4,4-trifluorocrotonate97%;ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE;ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE;2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR;Ethyl 3-amino-4,4,4-trifluorocrotonate 97%
CBNumber: CB2742977
Molecular Formula: C6H8F3NO2
Formula Weight: 183.13
MOL File: 372-29-2.mol

More

Less

Ethyl 3-amino-4,4,4-trifluorocrotonate Property

Melting point:: 26°C
Boiling point:: 83 °C15 mm Hg(lit.)
Density: 1.245 g/mL at 25 °C(lit.)
refractive index: n20/D 1.424(lit.)
Flash point:: 149 °F
storage temp.: 2-8°C(protect from light)
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Colourless to Pale Yellow Low-Melting to Semi-Solid
pka: 0.76±0.70(Predicted)
color: White or Colorless to Light yellow
FreezingPoint: 22.0 to 26.0 ℃
Sensitive: Air Sensitive
BRN: 4397839
InChIKey: NXVKRKUGIINGHD-ONEGZZNKSA-N
CAS DataBase Reference: 372-29-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37
Safety Statements: 26-36-36/37
RIDADR: 3259
WGK Germany: 3
Hazard Note: Toxic/Irritant
HazardClass: IRRITANT
HazardClass: 8
HS Code: 29224999

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 443697
Product name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Purity: 96%
Packaging: 10G
Price: $44.6
Updated: 2023/01/07

TCI Chemical

Product number: A1475
Product name: Ethyl 3-Amino-4,4,4-trifluorocrotonate
Purity: >97.0%(GC)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: A1475
Product name: Ethyl 3-Amino-4,4,4-trifluorocrotonate
Purity: >97.0%(GC)
Packaging: 25g
Price: $68
Updated: 2025/07/31

TRC

Product number: E899680
Product name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E899680
Product name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Packaging: 1g
Price: $50
Updated: 2021/12/16

More

Less

Ethyl 3-amino-4,4,4-trifluorocrotonate Chemical Properties,Usage,Production

Chemical Properties

Colourless liquid or white solid

Uses

Ethyl 3-amino-4,4,4-trifluorocrotonate is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis

383-63-1

141-78-6

372-29-2

A slurry of sodium enolides was prepared from ethyl trifluoroacetate (88.1 g, 1.0 mol) and ethyl acetate (71.05 g, 0.50 mol) by mixing with solid sodium ethoxide (34.05 g, 0.5 mol). The mixture was evaporated and concentrated with reference to the operation of Example 1. Subsequently, 250 ml of cyclohexane was added to the reaction system, followed by ammonium acetate (77.1 g, 1.0 mol) and anhydrous acetic acid (39.0 g, 0.65 mol). The resulting suspension was heated to boiling, water was separated by distillation and cyclohexane was refluxed into the reaction mixture. The reaction was terminated after 5 hours. The organic phase was separated by adding 300 mL of water. Cyclohexane was removed from the organic phase by distillation and the product was subsequently fractionated under vacuum. 57.0 g of ethyl 3-amino-4,4,4-trifluorobut-2-enoate was obtained with 97.4% purity and 62% yield. The product was analyzed by EI mass spectrometry ([M+] = 183 AMU), 1H-NMR (7.6 ppm, NH; 4.86 ppm, 1H, CH; 4.08 ppm, Quadruple peak, 2H, ethyl; 1.18 ppm, Triple peak, 3H, ethyl) and 13C-NMR (168 ppm, COOEt; 147 ppm, Quadruple peak, C-NH2. 120 ppm, broad quadruple peak, CF3; 82 ppm, quadruple peak, CH; 59 ppm, ethyl; 14 ppm, ethyl) were characterized.

References

[1] Patent: WO2004/16579, 2004, A1. Location in patent: Page 9; 10

Ethyl 3-amino-4,4,4-trifluorocrotonate Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Ammonium hydroxide Ethanol Ammonium acetate

Preparation Products

More

Less

Ethyl 3-amino-4,4,4-trifluorocrotonate Suppliers

Americas 1 Australia 1 Belgium 4 Brazil 1 Canada 2 China 244 Europe 3 France 2 Germany 8 India 11 Ireland 1 Italy 1 Japan 3 Slovakia 1 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 46 Global 352

Jinan Wanxingda New Material Technology Co., Ltd.

Tel: 0531-88064106 18253116016
Email: zhangjia@wxdchem.com
Country: China
ProdList: 43
Advantage: 58

Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd

Tel: 0576-88685096 13989620089
Fax: 0086-576-88685099
Email: sales@yfchem.cn
Country: China
ProdList: 9
Advantage: 65

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 5010
Advantage: 58

Ningbo Jiaheshan New Material Co., LTD

Tel: 13758655631
Email: 2573039014@qq.com
Country: China
ProdList: 18
Advantage: 58

Shanghai Jiahua Herong Biotechnology Co., Ltd

Tel: 13122653442 13122653442
Email: hr@bettersyn.com
Country: China
ProdList: 193
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44734
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

More

Less

View Lastest Price from Ethyl 3-amino-4,4,4-trifluorocrotonate manufacturers

Sichuan Zhuoyu Yantang Technology Co., Ltd.

Product: Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2025-09-09

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-22

372-29-2, Ethyl 3-amino-4,4,4-trifluorocrotonateRelated Search:

2-AMINODIETHYLMALONATE CHLOROETHANE Ethylbenzene 3-Amino-2-butenoic acid ethyl ester ETHYL 3-AMINOCROTONATE Ethanol Ethyl acrylate Ethyl formate Ethylparaben Ethyl acetate Benzocaine Ethyl 4-bromocrotonate Ethyl crotonate Urethane Ethyl cellulose ETHYL 3-METHYLAMINO-4,4,4-TRIFLUOROCROTONATE Crotonic acid Diethyl ether

Ethyl 3-amino-4,4,4-trifluorocrotote

4-trifluorocrotonate

Ethyl 3-amino-4

Ethyl 3-amino-4,4,4-trifluorocrotonate, 98.5%

3-Amino-4,4,4-trifluor-crotonsaeure-aethylester

ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE

ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE

ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE

2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUORO, ETHYL ESTER

3-AMINO-4,4,4-TRIFLUOROCROTONIC ACID ETHYL ESTER

3-AMINO-4,4,4-TRIFLUOROCROTONIC ETHYL ESTER

Ethyl 3-Amino-4,4,4-Trifluorocrotonate Ethyl 3-Amino-4,4,4-Trifluoro-2-Butenoate

Ethyl 3-amino-4,4,4-trifluorocrotonate 97%

Ethyl3-amino-4,4,4-trifluorocrotonate97%

Ethyl 3-amino-4,4,4-trifluorocrotonate,96%

2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR

Ethyl 3-amino-4,4,4-trifluorocrotonate ,99%

ethyl (2Z)-3-aMino-4,4,4-trifluorobut-2-enoate

(Z)-ethyl 3-aMino-4,4,4-trifluorobut-2-enoate

Ethyl 3-Amino-4,4,4-trifluorocrotonate &gt

3- Amino-4,4, 4-trifluorobartanate, ethyl ester

TIANFU CHEM---Ethyl 3-amino-4,4,4-trifluorocrotonate

ethyl 3-amino-4,4,4-trifluro crotonate

372-29-2

C6H8F3NO2

C6H8NO2F3

CF3CNH2CHCO2C2H5

Building Blocks

Carbonyl Compounds

C6 to C7

AMINE

Organic Building Blocks

Esters

Fluorinated ketene derivatives

Ketene derivatives