ChemicalBook > CAS DataBase List > Ethyl 3-amino-4,4,4-trifluorocrotonate

Ethyl 3-amino-4,4,4-trifluorocrotonate

Product Name
Ethyl 3-amino-4,4,4-trifluorocrotonate
CAS No.
372-29-2
Chemical Name
Ethyl 3-amino-4,4,4-trifluorocrotonate
Synonyms
Ethyl 3-amino-4;4-trifluorocrotonate;Ethyl 3-amino-4,4,4-trifluorocrotote;ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE;ethyl 3-amino-4,4,4-trifluro crotonate;Ethyl3-amino-4,4,4-trifluorocrotonate97%;ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE;ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE;2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR;Ethyl 3-amino-4,4,4-trifluorocrotonate 97%
CBNumber
CB2742977
Molecular Formula
C6H8F3NO2
Formula Weight
183.13
MOL File
372-29-2.mol
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Ethyl 3-amino-4,4,4-trifluorocrotonate Property

Melting point:
26°C
Boiling point:
83 °C15 mm Hg(lit.)
Density 
1.245 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.424(lit.)
Flash point:
149 °F
storage temp. 
2-8°C(protect from light)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Colourless to Pale Yellow Low-Melting to Semi-Solid
pka
0.76±0.70(Predicted)
color 
White or Colorless to Light yellow
FreezingPoint 
22.0 to 26.0 ℃
Sensitive 
Air Sensitive
BRN 
4397839
InChIKey
NXVKRKUGIINGHD-ONEGZZNKSA-N
CAS DataBase Reference
372-29-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
20/21/22-36/37
Safety Statements 
26-36-36/37
RIDADR 
3259
WGK Germany 
3
Hazard Note 
Toxic/Irritant
HazardClass 
IRRITANT
HazardClass 
8
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
443697
Product name
Ethyl 3-amino-4,4,4-trifluorocrotonate
Purity
96%
Packaging
10G
Price
$44.6
Updated
2023/01/07
TCI Chemical
Product number
A1475
Product name
Ethyl 3-Amino-4,4,4-trifluorocrotonate
Purity
>97.0%(GC)
Packaging
5g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
A1475
Product name
Ethyl 3-Amino-4,4,4-trifluorocrotonate
Purity
>97.0%(GC)
Packaging
25g
Price
$68
Updated
2025/07/31
TRC
Product number
E899680
Product name
Ethyl 3-amino-4,4,4-trifluorocrotonate
Packaging
500mg
Price
$45
Updated
2021/12/16
TRC
Product number
E899680
Product name
Ethyl 3-amino-4,4,4-trifluorocrotonate
Packaging
1g
Price
$50
Updated
2021/12/16
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Ethyl 3-amino-4,4,4-trifluorocrotonate Chemical Properties,Usage,Production

Chemical Properties

Colourless liquid or white solid

Uses

Ethyl 3-amino-4,4,4-trifluorocrotonate is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis

383-63-1

141-78-6

372-29-2

A slurry of sodium enolides was prepared from ethyl trifluoroacetate (88.1 g, 1.0 mol) and ethyl acetate (71.05 g, 0.50 mol) by mixing with solid sodium ethoxide (34.05 g, 0.5 mol). The mixture was evaporated and concentrated with reference to the operation of Example 1. Subsequently, 250 ml of cyclohexane was added to the reaction system, followed by ammonium acetate (77.1 g, 1.0 mol) and anhydrous acetic acid (39.0 g, 0.65 mol). The resulting suspension was heated to boiling, water was separated by distillation and cyclohexane was refluxed into the reaction mixture. The reaction was terminated after 5 hours. The organic phase was separated by adding 300 mL of water. Cyclohexane was removed from the organic phase by distillation and the product was subsequently fractionated under vacuum. 57.0 g of ethyl 3-amino-4,4,4-trifluorobut-2-enoate was obtained with 97.4% purity and 62% yield. The product was analyzed by EI mass spectrometry ([M+] = 183 AMU), 1H-NMR (7.6 ppm, NH; 4.86 ppm, 1H, CH; 4.08 ppm, Quadruple peak, 2H, ethyl; 1.18 ppm, Triple peak, 3H, ethyl) and 13C-NMR (168 ppm, COOEt; 147 ppm, Quadruple peak, C-NH2. 120 ppm, broad quadruple peak, CF3; 82 ppm, quadruple peak, CH; 59 ppm, ethyl; 14 ppm, ethyl) were characterized.

References

[1] Patent: WO2004/16579, 2004, A1. Location in patent: Page 9; 10

Ethyl 3-amino-4,4,4-trifluorocrotonate Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Ammonium hydroxide Ethanol Ammonium acetate

Preparation Products

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Ethyl 3-amino-4,4,4-trifluorocrotonate Suppliers

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View Lastest Price from Ethyl 3-amino-4,4,4-trifluorocrotonate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-22
Henan Aochuang Chemical Co.,Ltd.
Product
Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2025-04-01

372-29-2, Ethyl 3-amino-4,4,4-trifluorocrotonateRelated Search:

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  • 372-29-2
  • C6H8F3NO2
  • C6H8NO2F3
  • CF3CNH2CHCO2C2H5
  • Building Blocks
  • Carbonyl Compounds
  • C6 to C7
  • AMINE
  • Organic Building Blocks
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  • Fluorinated ketene derivatives
  • Ketene derivatives