Ethyl 3-amino-4,4,4-trifluorocrotonate

Product Name: Ethyl 3-amino-4,4,4-trifluorocrotonate
CAS No.: 372-29-2
Chemical Name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Synonyms: Ethyl 3-amino-4;4-trifluorocrotonate;Ethyl 3-amino-4,4,4-trifluorocrotote;ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE;ethyl 3-amino-4,4,4-trifluro crotonate;Ethyl3-amino-4,4,4-trifluorocrotonate97%;ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE;ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE;2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR;Ethyl 3-amino-4,4,4-trifluorocrotonate 97%
CBNumber: CB2742977
Molecular Formula: C6H8F3NO2
Formula Weight: 183.13
MOL File: 372-29-2.mol

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Ethyl 3-amino-4,4,4-trifluorocrotonate Property

Melting point:: 26°C
Boiling point:: 83 °C15 mm Hg(lit.)
Density: 1.245 g/mL at 25 °C(lit.)
refractive index: n20/D 1.424(lit.)
Flash point:: 149 °F
storage temp.: 2-8°C(protect from light)
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Colourless to Pale Yellow Low-Melting to Semi-Solid
pka: 0.76±0.70(Predicted)
color: White or Colorless to Light yellow
FreezingPoint: 22.0 to 26.0 ℃
Sensitive: Air Sensitive
BRN: 4397839
InChIKey: NXVKRKUGIINGHD-ONEGZZNKSA-N
CAS DataBase Reference: 372-29-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37
Safety Statements: 26-36-36/37
RIDADR: 3259
WGK Germany: 3
Hazard Note: Toxic/Irritant
HazardClass: IRRITANT
HazardClass: 8
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 443697
Product name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Purity: 96%
Packaging: 10G
Price: $44.6
Updated: 2023/01/07

TCI Chemical

Product number: A1475
Product name: Ethyl 3-Amino-4,4,4-trifluorocrotonate
Purity: >97.0%(GC)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: A1475
Product name: Ethyl 3-Amino-4,4,4-trifluorocrotonate
Purity: >97.0%(GC)
Packaging: 25g
Price: $68
Updated: 2025/07/31

TRC

Product number: E899680
Product name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E899680
Product name: Ethyl 3-amino-4,4,4-trifluorocrotonate
Packaging: 1g
Price: $50
Updated: 2021/12/16

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Ethyl 3-amino-4,4,4-trifluorocrotonate Chemical Properties,Usage,Production

Chemical Properties

Colourless liquid or white solid

Uses

Ethyl 3-amino-4,4,4-trifluorocrotonate is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis

383-63-1

141-78-6

372-29-2

A slurry of sodium enolides was prepared from ethyl trifluoroacetate (88.1 g, 1.0 mol) and ethyl acetate (71.05 g, 0.50 mol) by mixing with solid sodium ethoxide (34.05 g, 0.5 mol). The mixture was evaporated and concentrated with reference to the operation of Example 1. Subsequently, 250 ml of cyclohexane was added to the reaction system, followed by ammonium acetate (77.1 g, 1.0 mol) and anhydrous acetic acid (39.0 g, 0.65 mol). The resulting suspension was heated to boiling, water was separated by distillation and cyclohexane was refluxed into the reaction mixture. The reaction was terminated after 5 hours. The organic phase was separated by adding 300 mL of water. Cyclohexane was removed from the organic phase by distillation and the product was subsequently fractionated under vacuum. 57.0 g of ethyl 3-amino-4,4,4-trifluorobut-2-enoate was obtained with 97.4% purity and 62% yield. The product was analyzed by EI mass spectrometry ([M+] = 183 AMU), 1H-NMR (7.6 ppm, NH; 4.86 ppm, 1H, CH; 4.08 ppm, Quadruple peak, 2H, ethyl; 1.18 ppm, Triple peak, 3H, ethyl) and 13C-NMR (168 ppm, COOEt; 147 ppm, Quadruple peak, C-NH2. 120 ppm, broad quadruple peak, CF3; 82 ppm, quadruple peak, CH; 59 ppm, ethyl; 14 ppm, ethyl) were characterized.

References

[1] Patent: WO2004/16579, 2004, A1. Location in patent: Page 9; 10

Ethyl 3-amino-4,4,4-trifluorocrotonate Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Ammonium hydroxide Ethanol Ammonium acetate

Preparation Products

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Ethyl 3-amino-4,4,4-trifluorocrotonate Suppliers

Americas 1 Australia 1 Belgium 4 Brazil 1 Canada 2 China 245 Europe 3 France 2 Germany 8 India 11 Ireland 1 Italy 1 Japan 3 Slovakia 1 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 46 Global 353

Matrix Fine Chemicals GmbH

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Country: Switzerland
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LONZA AG

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Lonza Group Ltd

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SIGMA-RBI

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Country: Switzerland
ProdList: 6896
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View Lastest Price from Ethyl 3-amino-4,4,4-trifluorocrotonate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-22

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2025-04-01

372-29-2, Ethyl 3-amino-4,4,4-trifluorocrotonateRelated Search:

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Ethyl 3-amino-4,4,4-trifluorocrotote

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Ethyl 3-amino-4,4,4-trifluorocrotonate 97%

Ethyl3-amino-4,4,4-trifluorocrotonate97%

Ethyl 3-amino-4,4,4-trifluorocrotonate,96%

2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR

Ethyl 3-amino-4,4,4-trifluorocrotonate ,99%

ethyl (2Z)-3-aMino-4,4,4-trifluorobut-2-enoate

(Z)-ethyl 3-aMino-4,4,4-trifluorobut-2-enoate

Ethyl 3-Amino-4,4,4-trifluorocrotonate &gt

3- Amino-4,4, 4-trifluorobartanate, ethyl ester

TIANFU CHEM---Ethyl 3-amino-4,4,4-trifluorocrotonate

ethyl 3-amino-4,4,4-trifluro crotonate

372-29-2

C6H8F3NO2

C6H8NO2F3

CF3CNH2CHCO2C2H5

Building Blocks

Carbonyl Compounds

C6 to C7

AMINE

Organic Building Blocks

Esters

Fluorinated ketene derivatives

Ketene derivatives