Ethyl 4-bromocrotonate
- Product Name
- Ethyl 4-bromocrotonate
- CAS No.
- 37746-78-4
- Chemical Name
- Ethyl 4-bromocrotonate
- Synonyms
- Ethyl (E)-4-bromobut-2-enoate;Ethyl (E)-4-bromo-2-butenoate;(E)-Ethyl 4-broMobut-2-enoate;Neratinib Impurity 26;thyl 4-bromocrotonate;ETHYL 4-BROMOCROTONATE;Ethyl-4-bromocrotanate;4- broMoethyl crotonate;Ethylbromocrotonatepract;Ethyl gamma-bromocrotonate
- CBNumber
- CB3111015
- Molecular Formula
- C6H9BrO2
- Formula Weight
- 193.04
- MOL File
- 37746-78-4.mol
Ethyl 4-bromocrotonate Property
- Boiling point:
- 94-95 °C/12 mmHg (lit.)
- Density
- 1.402 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.493(lit.)
- Flash point:
- 207 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Liquid
- Specific Gravity
- 1.402
- color
- Clear light yellow to brown
- Water Solubility
- Insoluble in water.
- BRN
- 1721388
- Stability:
- Light Sensitive
- InChIKey
- FHGRPBSDPBRTLS-ONEGZZNKSA-N
- CAS DataBase Reference
- 37746-78-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Butenoic acid, 4-bromo-, ethyl ester, (E)-(37746-78-4)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-45-24/25
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10-19-23
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29161995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E13830
- Product name
- Ethyl 4-bromocrotonate
- Purity
- 75%, technical grade
- Packaging
- 5g
- Price
- $53.2
- Updated
- 2025/07/31
- Product number
- E13830
- Product name
- Ethyl 4-bromocrotonate
- Purity
- 75%, technical grade
- Packaging
- 25g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- E676685
- Product name
- (E)-Ethyl4-Bromobut-2-enoate(>80%)
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- E676685
- Product name
- (E)-Ethyl4-Bromobut-2-enoate(>80%)
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- C269
- Product name
- Ethyl 4-bromocrotonate
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
Ethyl 4-bromocrotonate Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid
Uses
Ethyl 4-bromocrotonate is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.
Synthesis
623-70-1
37746-78-4
General procedure for the synthesis of ethyl (E)-4-bromobut-2-enoate from ethyl crotonate: To a round-bottomed flask containing ethyl (2E)-but-2-enoate (10.9 g, 87.6 mmol) and carbon tetrachloride (100 mL), N-bromosuccinimide (NBS, 17 g, 96 mmol) and azobisisobutyronitrile (AIBN, 4.3 g, 26 mmol). The reaction mixture was stirred at 80 °C for 12 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane (DCM) and washed sequentially with saturated sodium bicarbonate solution, water and brine. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give ethyl (E)-4-bromobut-2-enoate (7.5 g, 44% yield) as an oil.
References
[1] Journal of the American Chemical Society, 2001, vol. 123, # 21, p. 4966 - 4973
[2] Patent: WO2017/100668, 2017, A1. Location in patent: Page/Page column 150
[3] Patent: WO2018/103058, 2018, A1. Location in patent: Page/Page column 150
[4] Bulletin de la Societe Chimique de France, 1966, p. 1315 - 1324
[5] Journal of Organometallic Chemistry, 1973, vol. 60, p. 209 - 217
Ethyl 4-bromocrotonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-bromocrotonate manufacturers
- Product
- Ethyl 4-bromocrotonate 37746-78-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-20
- Product
- Ethyl 4-bromocrotonate 37746-78-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-10