Ethyl 4-bromobutyrate
- Product Name
- Ethyl 4-bromobutyrate
- CAS No.
- 2969-81-5
- Chemical Name
- Ethyl 4-bromobutyrate
- Synonyms
- Ethyl 4-bromobutanoate;4- broMobutanoate;4-BROMOBUTYRIC ACID ETHYL ESTER;4- broMo ethyl;4-bromohexanoate;4-Bromobutylester;Ethyl 4-broMobutyr;BrCH2CH2CH2C(O)OC2H5;Ethl 4-broMobutyrate;Ethyl 4-bromibutyrate
- CBNumber
- CB5216846
- Molecular Formula
- C6H11BrO2
- Formula Weight
- 195.05
- MOL File
- 2969-81-5.mol
Ethyl 4-bromobutyrate Property
- Melting point:
- 98-100 °C
- Boiling point:
- 80-82 °C/10 mmHg (lit.)
- Density
- 1.363 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.456(lit.)
- Flash point:
- 195 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
- form
- Liquid
- Specific Gravity
- 1.363
- color
- Clear colorless to yellow
- Water Solubility
- immiscible
- BRN
- 1749700
- InChIKey
- XBPOBCXHALHJFP-UHFFFAOYSA-N
- CAS DataBase Reference
- 2969-81-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl 4-bromobutyrate(2969-81-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 2915900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 167118
- Product name
- Ethyl 4-bromobutyrate
- Purity
- 95%
- Packaging
- 50g
- Price
- $60.9
- Updated
- 2025/07/31
- Product number
- 167118
- Product name
- Ethyl 4-bromobutyrate
- Purity
- 95%
- Packaging
- 250g
- Price
- $186.9
- Updated
- 2025/07/31
- Product number
- B0999
- Product name
- Ethyl 4-Bromobutyrate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- B0999
- Product name
- Ethyl 4-Bromobutyrate
- Purity
- >97.0%(GC)
- Packaging
- 100g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- B0999
- Product name
- Ethyl 4-Bromobutyrate
- Purity
- >97.0%(GC)
- Packaging
- 500g
- Price
- $177
- Updated
- 2025/07/31
Ethyl 4-bromobutyrate Chemical Properties,Usage,Production
Description
Ethyl 4-bromobutyrate is a colourless volatile liquid organic or biological reagent. It is used in organic synthesis to prepare 4-bromobutyl ester, 4-bromobutyl amide and 4-bromobutyl ether. It is also used in the synthesis of poly(2,6-dimethyl-1,4-epoxyphenyl ether) and isotopic thieno[2,3-b]azepin-4-one thieno[2,3-b]-azepin-4-one with antitumour activity. In the biological field, it has been used in enzyme-linked immunosorbent assays for zilpaterol.
Chemical Properties
clear colorless to yellow liquid
Uses
A versatile building block and synthesis reagent
Uses
Ethyl 4-bromobutyrate is used as a building block for the preparation of firefly luciferase inhibitor-conjucated peptide derivatives. It finds application in the synthesis of poly(2,6,-dimethyl-1,4-phehylene oxide) and thieno(2,3-b)-azepin-4-ones.
Synthesis Reference(s)
The Journal of Organic Chemistry, 56, p. 2264, 1991 DOI: 10.1021/jo00006a061
Hazard
Strongly irritating to skin and eyes
Synthesis
2623-87-2
2969-81-5
Part A: Synthesis of ethyl 4-bromobutyrate To a solution of 4-bromobutyric acid (3 g, 18 mmol) in ethanol (30 mL) was added 5 mL of a dioxane solution of 4N HCl. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the volatile components were removed under vacuum. The concentrated residue was dissolved in 150 mL of dichloromethane. The organic phase was washed sequentially with saturated aqueous NaHCO3 (1 x 150 mL) and brine (1 x 150 mL), dried over anhydrous MgSO4, filtered, and the filtrate was concentrated under reduced pressure. The concentrated residue was dried under vacuum to give 3 g (85.5% yield) of ethyl 4-bromobutyrate as a yellow oil.1H NMR (300 MHz, CDCl3): δ1.22 (t, 3H, J = 7.15 Hz), 2.13 (m, 2H, J = 6.80 Hz), 2.45 (t, 2H, J = 7.15 Hz), 3.43 (t , 2H, J = 6.44Hz), 4.10 (q, 2H, J = 7.25Hz).
References
[1] Patent: US5753660, 1998, A
Ethyl 4-bromobutyrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-bromobutyrate manufacturers
- Product
- Ethyl 4-bromobutyrate 2969-81-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-27
- Product
- Ethyl 4-bromobutyrate 2969-81-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2025-08-05
- Product
- Ethyl 4-bromobutyrate 2969-81-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-29