Ethyl trifluoroacetate

Product Name: Ethyl trifluoroacetate
CAS No.: 383-63-1
Chemical Name: Ethyl trifluoroacetate
Synonyms: ETHYL 2,2,2-TRIFLUOROACETATE;ETFA;TFAET;TRIFLUOROACETIC ACID ETHYL ESTER;CF3COOC2H5;RARECHEM AL BI 0416;2,2,2-Trifluoroacetic acid ethyl ester;cb1020;fd06h11;wu:fd06h11
CBNumber: CB6349488
Molecular Formula: C4H5F3O2
Formula Weight: 142.08
MOL File: 383-63-1.mol

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Ethyl trifluoroacetate Property

Melting point:: -78 °C
Boiling point:: 60-62 °C(lit.)
Density: 1.194 g/mL at 25 °C(lit.)
vapor pressure: 18.5kPa at 20℃
refractive index: n20/D 1.307(lit.)
Flash point:: 30 °F
storage temp.: 2-8°C
solubility: 4g/l
form: Liquid
pka: 0.43[at 20 ℃]
Specific Gravity: 1.194
color: Clear
PH: 4 (4g/l, H2O, 20℃)
Water Solubility: HYDROLYSIS
Sensitive: Moisture Sensitive
BRN: 1761411
Stability:: Hygroscopic, Moisture Sensitive, Volatile
InChIKey: STSCVKRWJPWALQ-UHFFFAOYSA-N
LogP: 0.79-1.032 at 25℃
CAS DataBase Reference: 383-63-1(CAS DataBase Reference)
NIST Chemistry Reference: Acetic acid, trifluoro-, ethyl ester(383-63-1)
EPA Substance Registry System: Ethyl trifluoroacetate (383-63-1)

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Safety

Hazard Codes: F,Xn,C
Risk Statements: 11-22-37/38-41-34
Safety Statements: 9-16-26-36/39-45-36/37/39
RIDADR: UN 1993 3/PG 2
WGK Germany: 1
Hazard Note: Flammable/Corrosive
TSCA: T
HazardClass: 3
PackingGroup: II
HS Code: 29159080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E50000
Product name: Ethyl trifluoroacetate
Purity: 99%
Packaging: 25g
Price: $33.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: E50000
Product name: Ethyl trifluoroacetate
Purity: 99%
Packaging: 100g
Price: $110
Updated: 2024/03/01

TCI Chemical

Product number: T0432
Product name: Ethyl Trifluoroacetate
Purity: >99.0%(GC)
Packaging: 25g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: T0432
Product name: Ethyl Trifluoroacetate
Purity: >99.0%(GC)
Packaging: 100g
Price: $98
Updated: 2024/03/01

Alfa Aesar

Product number: A11520
Product name: Ethyl trifluoroacetate, 99%
Packaging: 50g
Price: $51.9
Updated: 2024/03/01

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Ethyl trifluoroacetate Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Uses

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Uses

Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.

Preparation

Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.

Definition

ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056

Flammability and Explosibility

Highly flammable

Purification Methods

Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]

Ethyl trifluoroacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid

Preparation Products

2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-CARBOXALDEHYDE EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE 8-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBONITRILE 3-TRIFLUOROACETYL-D-CAMPHOR 6,7-DIMETHOXY-3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 2-AMINO-6-T-BUTYL-4-(TRIFLUOROMETHYL)PYRIMIDINE METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE Efavirenz HEXAFLUOROACETYLACETONE

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Ethyl trifluoroacetate Suppliers

Australia 1 Austria 1 Belgium 4 Brazil 1 Canada 2 China 378 Europe 4 France 2 Germany 11 India 37 Ireland 1 Italy 1 Japan 12 Russia 2 Slovakia 1 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 22 United States 59 Global 545

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.

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XIANJU DOEASTCHEM Co., Ltd.

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Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd

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Energy Chemical

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Jinan New Era Chemical Co., Ltd.

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Linyi Hongda Chemical Co., Ltd

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Jinan Jumeihui Chemical Co., Ltd

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Shandong longyue of chemical co., LTD

Tel: 15318857512
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View Lastest Price from Ethyl trifluoroacetate manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: Ethyl trifluoroacetate 383-63-1
Price: US $5.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 5t
Release date: 2022-01-18

Hebei Guanlang Biotechnology Co,.LTD

Product: Ethyl Trifluoroacetate 383-63-1
Price: US $10.70/Kg/Drum
Min. Order: 10g
Purity: 99%
Supply Ability: 10000kg
Release date: 2021-07-26

Hebei Guanlang Biotechnology Co., Ltd.

Product: Ethyl trifluoroacetate 383-63-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-03-10

383-63-1, Ethyl trifluoroacetateRelated Search:

Ethyl fluoroacetate Trifluoroacetic anhydride Ethyl cellulose Ethylbenzene Trifluoroacetic acid CHLOROETHANE Ethylparaben ETHYL CHLOROFLUOROACETATE Ethanol Ethyl acetate Ethyl difluoroacetate 2,2,2-Trifluoroethyl acrylate Ethyl acrylate Ethyl formate 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE TRICAPRIN Triethylene glycol diacetate TRIMETHYLSILYL ISOCYANATE

RARECHEM AL BI 0416

ETHYL 2,2,2-TRIFLUOROACETATE

ETHYL TRIFLUOROACETATE

TIMTEC-BB SBB008466

TRIFLUOROACETIC ACID ETHYL ESTER

Threetrifluoroacetic acid ethyl ester

cb1020

fd06h11

wu:fd06h11

aceticacid,trifluoro-,ethylester

CF3COOC2H5

Ethyl ester of Trifluoroacetic acid

Ethyl trifluoroethanoate

ethylperfluoroacetate

Trifluoressigsαureethylester

trifluoro-aceticaciethylester

Ethyltrifluoroacetate(ETFA)

VITAS-BB TBB000648

3,4,5-Trimethoxybenzenesulfonic Acid Sodium

TFAET

ETHYL TRIFLUOROACETATE 98% (GC)

Ethyl trifluoroacetate,99%

Ethyl trifluoroacetate 99%

2,2,2-TRIFLOUROETHYL ACETATE (TFAET)

Ethyltrifluoracetat

2,2,2-Trifluoroacetic acid ethyl ester

trifluoroacetatic acid ethyl ester

Ethyl trifluoroacetate, 98+%

Ethyl trifluoroaceta

Trifluoroacetic acid ethyl

Ethyl 4-trifluoroacetate

Ethyl trifluoroacetate, 99% 100ML

Ethyl trifluoroacetate, 99% 25ML

ETFA

Ethyl trifluoroacetate or Propyl ester

Ethyltrifuoroacetate

Ethyl Trifluoroacetate &gt

ETHYL TRIFLUOROACETATE For Synthesis

Sitagliptin Impurity 76

Ethyl trifluoroacetate（TFAE）

383-63-1

C4H5F3O2

CF3CO2CH2CH3

CF3CO2C2H5

F3CCOOC2H5

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organofluorine compounds

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C2 to C5

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