4,4,4-Trifluoro-1-phenyl-1,3-butanedione

Product Name: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione
CAS No.: 326-06-7
Chemical Name: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione
Synonyms: 4,4,4-TRIFLUORO-1-PHENYLBUTANE-1,3-DIONE;3-BENZOYL-1,1,1-TRIFLUOROACETONE;BENZOYLTRIFLUOROACETONE;BENZOYL-1,1,1-TRIFLUOROACETONE;NSC 42628;NSC 405720;AKOS MSC-0330;Celecoxib Impurity 35;LABOTEST-BB LT00005189;4-Phenyl-1,1,1-trifluorobuta
CBNumber: CB5331972
Molecular Formula: C10H7F3O2
Formula Weight: 216.16
MOL File: 326-06-7.mol

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4,4,4-Trifluoro-1-phenyl-1,3-butanedione Property

Melting point:: 38-40 °C(lit.)
Boiling point:: 224 °C(lit.)
Density: 1,113 g/cm³
Flash point:: 210 °F
storage temp.: Sealed in dry,Room Temperature
solubility: 95% ethanol: soluble25mg/mL, clear, colorless to yellow
form: Crystalline Low Melting Solid
pka: pK1: 6.35 (25°C)
color: White to yellow
Water Solubility: Sparingly Soluble in water (0.24 g/L) (25°C).
BRN: 1875083
InChI: InChI=1S/C10H7F3O2/c11-10(12,13)9(15)6-8(14)7-4-2-1-3-5-7/h1-5H,6H2
InChIKey: VVXLFFIFNVKFBD-UHFFFAOYSA-N
SMILES: C(C1=CC=CC=C1)(=O)CC(=O)C(F)(F)F
CAS DataBase Reference: 326-06-7(CAS DataBase Reference)
EPA Substance Registry System: 1,3-Butanedione, 4,4,4-trifluoro-1-phenyl- (326-06-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25
WGK Germany: 3
TSCA: TSCA listed
HazardClass: IRRITANT
HS Code: 29147000
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 217042
Product name: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione
Purity: 99%
Packaging: 25g
Price: $94.5
Updated: 2025/07/31

TCI Chemical

Product number: T0437
Product name: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione
Purity: >98.0%(GC)
Packaging: 25g
Price: $114
Updated: 2025/07/31

Strem Chemicals

Product number: 09-1210
Product name: Benzoyl-1,1,1-trifluoroacetone, 98%
Packaging: 10g
Price: $45
Updated: 2024/03/01

Strem Chemicals

Product number: 09-1210
Product name: Benzoyl-1,1,1-trifluoroacetone, 98%
Packaging: 50g
Price: $138
Updated: 2024/03/01

TRC

Product number: B209730
Product name: Benzoyl-1,1,1-trifluoroacetone
Packaging: 5g
Price: $50
Updated: 2021/12/16

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4,4,4-Trifluoro-1-phenyl-1,3-butanedione Chemical Properties,Usage,Production

Chemical Properties

WHITE TO YELLOW CRYSTALLINE LOW MELTING SOLID

Uses

4,4,4-Trifluoro-1-phenyl-1,3-butanedione was used in the synthesis of series of NNO ketoimines bearing trifluoromethyl substituents via Schiff base condensation reaction. It was also used in mixed-ligand chelate extraction of trivalent lanthanides and as a ligand in the preparation of ternary lanthanide (Ln) complexes.

Synthesis

To a three-necked flask fitted with magnetic stirring, a dropping funnel and an inert gas device, 2 mL of anhydrous methanol was added with stirring and 0.230 g (10 ) of clean sodium metal crumbs were added. mmol) of clean sodium metal crumbs, and after all the sodium was dissolved, a water bath was installed to evaporate the unreacted methanol in the reaction system. After the sodium methanol was completely dried, 5 was added mL of anhydrous ether, quickly stirred well, and then cooled in an ice bath. 1.2 mL (10 mmol) of ethyl trifluoroacetate was diluted with 5 mL of anhydrous ether was diluted and added to the reaction flask. The ice bath was removed and 1.1 mL (10 mmol) acetophenone was diluted with 5 mL of anhydrous ether was diluted and added dropwise to the reaction system using a dropping funnel. The reaction was stirred at reflux for five hours and at the end of the reaction 10 was added mL of water was added to dissolve the resulting solid and the mixture was extracted with ether to remove unreacted ketones and esters. The aqueous phase was acidified with 0.5 mL (10 ) glacial acetic acid was acidified and then extracted with ether in portions, the organic phases were combined, dried with anhydrous magnesium sulfate and filtered. After the filtrate was evaporated from the ether, a light-yellow crystalline low-melting solid powder 1.691 was precipitated. g. The light yellow solid powder was recrystallized with ethanol-water to obtain light yellow pure benzoyltrifluoroacetone.

4,4,4-Trifluoro-1-phenyl-1,3-butanedione Preparation Products And Raw materials

Raw materials

Sodium Acetophenone Ethyl trifluoroacetate

Preparation Products

2-OXO-6-PHENYL-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

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4,4,4-Trifluoro-1-phenyl-1,3-butanedione Suppliers

Belgium 2 China 224 Europe 1 France 1 Germany 5 India 4 Japan 2 Russia 2 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 26 Global 283

Fluoropharm Co., Ltd.

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Energy Chemical

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View Lastest Price from 4,4,4-Trifluoro-1-phenyl-1,3-butanedione manufacturers

Sach biotech Co.,Ltd

Product: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 326-06-7
Price: US $260.00-220.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5mt
Release date: 2025-06-11

Henan Aochuang Chemical Co.,Ltd.

Product: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 326-06-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Career Henan Chemical Co

Product: BENZOYL-1,1,1-TRIFLUOROACETONE 326-06-7
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-17

326-06-7, 4,4,4-Trifluoro-1-phenyl-1,3-butanedioneRelated Search:

4,4,4-TRIFLUORO-1-(2-NAPHTHYL)-1,3-BUTANEDIONE 4,4,4-TRIFLUORO-1-(4-METHOXYPHENYL)-1,3-BUTANEDIONE 1-(4-CHLOROPHENYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE 4,4,4-TRIFLUORO-1-(4-FLUOROPHENYL)BUTANE-1,3-DIONE 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 4,4,4-Trifluoro-1-(p-tolyl)-1,3-butanedione Fluoroacetone Acetone 1,1,1-Trifluoroacetone Benzoylacetone 1-(4-BROMO-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 4,4,4-TRIFLUORO-1-(3,4,5-TRIMETHOXYPHENYL)-1,3-BUTANEDIONE 1-(3,4-DIMETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE 1-(3-CHLOROPHENYL)-4,4,4-TRIFLUOROBUTANE-1,3-DIONE 1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 4,4,4-trifluoro-1-(2-methylphenyl)butane-1,3-dione 1-(2-CHLOROPHENYL)-4,4,4-TRIFLUOROBUTANE-1,3-DIONE

TRIFLUORO-1-PHENYL-1,3-BUTANEDIONE

1,1,1-Trifluoro-4-phenyl-2,4-butanedione

1-Benzoyl-3,3,3-trifluoro-2-propanone

1-Benzoyl-3,3,3-trifluoroacetone

4,4,4-Trifluoro-1-phenylbutane-1,3-dione ,98%

ω-(Trifluoroacetyl)acetophenone

4,4,4-Trifluoro-1-phenyl-1,3-butanedione,99%

4-Phenyl-1,1,1-trifluorobuta

4,4,4-Trifluoro-1-phenyl-1,3-butanedione 99%

3-BENZOYL-1,1,1-TRIFLUOROACETONE

1,1,1-TRIFLUORO-4-PHENYLBUTANE-2,4-DIONE

BENZOYL-1 1 1-TRIFLUOROACETONE 98%

Benzoyltrifluoroacetone, 98+%

BENZOYL-1,1,1-TRIFLUOROACETONE IN TOLUENE

Benzoyl-1,1,1-trifluoroacetone,98%

3-Benzoyl 1,1,1-trifluoroacetate

3-Benzoyl-1,1,1-trifluoroacetone 98%

3-Benzoyl-1,1,1-trifluoroacetone98%

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

NSC 405720

NSC 42628

1-Phenyl-4,4,4-trifluoro-1,3-butanedione

4,4,4-trifluoro-1-phenyl-3-butanedione

4-Phenyl-1,1,1-trifluorobutane-2,4-dione

Benzoyl(trifluoroacetyl)methane

omega-(Trifluoroacetyl)acetophenone

w-(Trifluoroacetyl)acetophenone

BENZOYL-1,1,1-TRIFLUOROACETONE

BENZOYLTRIFLUOROACETONE

LABOTEST-BB LT00005189

AKOS MSC-0330

4,4,4-TRIFLUORO-1-PHENYL-1,3-BUTANEDIONE

4,4,4-TRIFLUORO-1-PHENYLBUTANE-1,3-DIONE

1-Phenyl-4,4,4-trifluorobutane-1,3-dione, 2,4-Dioxo-4-phenyl-1,1,1-trifluorobutane

Celecoxib Impurity 35

4,4,4-Trifluoro-1-phenylbutane-1,3-dione, 98%, for synthesis

4,4,4-Trifluoro-1-phenyl-1,3-butanedione &gt

1,3-Butanedione, 4,4,4-trifluoro-1-phenyl-

326-06-7

C6H5COCH2COCF3

Organic Building Blocks

Ketones

KETONE

Building Blocks

C10

Carbonyl Compounds

organofluorine compounds

Miscellaneous