ChemicalBook > CAS DataBase List > Ethyl trifluoroacetate

Ethyl trifluoroacetate

Product Name
Ethyl trifluoroacetate
CAS No.
383-63-1
Chemical Name
Ethyl trifluoroacetate
Synonyms
ETHYL 2,2,2-TRIFLUOROACETATE;ETFA;TFAET;TRIFLUOROACETIC ACID ETHYL ESTER;CF3COOC2H5;RARECHEM AL BI 0416;2,2,2-Trifluoroacetic acid ethyl ester;cb1020;fd06h11;wu:fd06h11
CBNumber
CB6349488
Molecular Formula
C4H5F3O2
Formula Weight
142.08
MOL File
383-63-1.mol
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Ethyl trifluoroacetate Property

Melting point:
-78 °C
Boiling point:
60-62 °C(lit.)
Density 
1.194 g/mL at 25 °C(lit.)
vapor pressure 
18.5kPa at 20℃
refractive index 
n20/D 1.307(lit.)
Flash point:
30 °F
storage temp. 
2-8°C
solubility 
4g/l
form 
Liquid
pka
0.43[at 20 ℃]
Specific Gravity
1.194
color 
Clear
PH
4 (4g/l, H2O, 20℃)
Water Solubility 
HYDROLYSIS
Sensitive 
Moisture Sensitive
BRN 
1761411
Stability:
Hygroscopic, Moisture Sensitive, Volatile
InChIKey
STSCVKRWJPWALQ-UHFFFAOYSA-N
LogP
0.79-1.032 at 25℃
CAS DataBase Reference
383-63-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, trifluoro-, ethyl ester(383-63-1)
EPA Substance Registry System
Ethyl trifluoroacetate (383-63-1)
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Safety

Hazard Codes 
F,Xn,C
Risk Statements 
11-22-37/38-41-34
Safety Statements 
9-16-26-36/39-45-36/37/39
RIDADR 
UN 1993 3/PG 2
WGK Germany 
1
Hazard Note 
Flammable/Corrosive
TSCA 
T
HazardClass 
3
PackingGroup 
II
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E50000
Product name
Ethyl trifluoroacetate
Purity
99%
Packaging
25g
Price
$33.2
Updated
2024/03/01
Sigma-Aldrich
Product number
E50000
Product name
Ethyl trifluoroacetate
Purity
99%
Packaging
100g
Price
$110
Updated
2024/03/01
TCI Chemical
Product number
T0432
Product name
Ethyl Trifluoroacetate
Purity
>99.0%(GC)
Packaging
25g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
T0432
Product name
Ethyl Trifluoroacetate
Purity
>99.0%(GC)
Packaging
100g
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
A11520
Product name
Ethyl trifluoroacetate, 99%
Packaging
50g
Price
$51.9
Updated
2024/03/01
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Ethyl trifluoroacetate Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Uses

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Uses

Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.

Preparation

Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.

Definition

ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056

Flammability and Explosibility

Highly flammable

Purification Methods

Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]

Ethyl trifluoroacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid

Preparation Products

2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-CARBOXALDEHYDE EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE 8-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBONITRILE 3-TRIFLUOROACETYL-D-CAMPHOR 6,7-DIMETHOXY-3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 2-AMINO-6-T-BUTYL-4-(TRIFLUOROMETHYL)PYRIMIDINE METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE Efavirenz HEXAFLUOROACETYLACETONE
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Australia 1 Austria 1 Belgium 4 Brazil 1 Canada 2 China 391 Europe 4 France 2 Germany 11 India 36 Ireland 1 Italy 1 Japan 12 Russia 2 Slovakia 1 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 22 United States 59 Global 557
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View Lastest Price from Ethyl trifluoroacetate manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Ethyl trifluoroacetate 383-63-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01
Qingdao RENAS Polymer Material Co., Ltd.
Product
Ethyl trifluoroacetate 383-63-1
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-08-26
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethyl Trifluoroacetate 383-63-1
Price
US $10.70/KG
Min. Order
10KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-13

383-63-1, Ethyl trifluoroacetateRelated Search:

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