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Ethyl 4,4,4-trifluoroacetoacetate

Product Name
Ethyl 4,4,4-trifluoroacetoacetate
CAS No.
372-31-6
Chemical Name
Ethyl 4,4,4-trifluoroacetoacetate
Synonyms
ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE;ETHYL TRIFLUOROACETOACETATE;ETFAA;4,4,4-trifL;AKOS B020306;uoroacetoacetate;TIMTEC-BB SBB008825;Ethyl 4,4,4-trifluor;4-trifluoroacetoacetate;Ethyl 4,4,4-trifluoroaceto
CBNumber
CB1133091
Molecular Formula
C6H7F3O3
Formula Weight
184.11
MOL File
372-31-6.mol
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Ethyl 4,4,4-trifluoroacetoacetate Property

Melting point:
-39 °C
Boiling point:
129-130 °C(lit.)
Density 
1.259 g/mL at 25 °C(lit.)
vapor pressure 
8hPa at 20℃
refractive index 
n20/D 1.375(lit.)
Flash point:
84 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
10g/l
form 
Liquid
pka
7.76±0.10(Predicted)
Specific Gravity
1.259 (20/4℃)
color 
Clear colorless to slightly yellow
PH
6.2 (10g/l, H2O, 20℃)
Water Solubility 
10 g/L (20 ºC)
BRN 
608353
InChIKey
OCJKUQIPRNZDTK-UHFFFAOYSA-N
CAS DataBase Reference
372-31-6(CAS DataBase Reference)
NIST Chemistry Reference
Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6)
EPA Substance Registry System
Ethyl 4,4,4-trifluoroacetoacetate (372-31-6)
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Safety

Hazard Codes 
Xn,F,C,Xi
Risk Statements 
10-22-52/53
Safety Statements 
61-16
RIDADR 
UN 3272 3/PG 3
WGK Germany 
2
Hazard Note 
Flammable/Corrosive
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29183000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T0810
Product name
Ethyl 4,4,4-Trifluoroacetoacetate
Purity
>98.0%(GC)
Packaging
25g
Price
$75
Updated
2024/03/01
TCI Chemical
Product number
T0810
Product name
Ethyl 4,4,4-Trifluoroacetoacetate
Purity
>98.0%(GC)
Packaging
100g
Price
$195
Updated
2024/03/01
Alfa Aesar
Product number
A13717
Product name
Ethyl trifluoroacetoacetate, 98+%
Packaging
10g
Price
$39.65
Updated
2024/03/01
Alfa Aesar
Product number
A13717
Product name
Ethyl trifluoroacetoacetate, 98+%
Packaging
50g
Price
$128.65
Updated
2024/03/01
Sigma-Aldrich
Product number
E50205
Product name
Ethyl 4,4,4-trifluoroacetoacetate
Purity
99%
Packaging
5g
Price
$32.8
Updated
2024/03/01
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Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties,Usage,Production

Chemical Properties

Clear liquid

Uses

Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet

Uses

Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Flammability and Explosibility

Flammable

Synthesis

With an ethanol solution of sodium ethoxide as a catalyst and in the presence of an organic solvent, ethyl trifluoroacetate and ethyl acetate are subjected to a Claisen condensation reaction, and ethyl 4,4,4-trifluoroacetoacetate is synthesized.

Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid

Preparation Products

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 2-Hydroxy-4-(trifluoromethyl)quinoline (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE THIFLUZAMIDE Ethyl 3-amino-4,4,4-trifluorocrotonate 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE 4-Methylpyrimidine 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97% Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% Coumarin 151 ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline 6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97% 4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-bromo-2-(trifluoromethyl)quinoline 4-(Trifluoromethyl)quinolin-2-amine 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone 4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE 2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE
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Ethyl 4,4,4-trifluoroacetoacetate Suppliers

Belgium 2 Canada 1 China 437 Europe 3 France 1 Germany 8 India 16 Ireland 1 Italy 1 Japan 5 Russia 1 Slovakia 1 Sweden 1 Switzerland 5 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 50 Global 554
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Ethyl 4,4,4-trifluoroacetoacetate manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl 4,4,4-trifluoroacetoacetate 372-31-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-25
Hebei Guanlang Biotechnology Co,.LTD
Product
Ethyl 4,4,4-trifluoroacetoacetate 372-31-6
Price
US $9.10/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10000
Release date
2021-08-20
Hebei Guanlang Biotechnology Co., Ltd.
Product
Ethyl 4,4,4-trifluoroacetoacetate 372-31-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-28

372-31-6, Ethyl 4,4,4-trifluoroacetoacetateRelated Search:

tert-Butyl acetoacetate Ethyl acetoacetate Ethyl 2-chloroacetoacetate Ethylparaben Methyl acetoacetate Ethyl formate Ethyl bromodifluoroacetate Ethanol Acetoxyacetic acid Ethyl cellulose Ethyl trifluoroacetate Ethyl 4-chloroacetoacetate Ethyl 4-bromoacetoacetate CHLOROETHANE Ethylbenzene Ethyl acetate Ethyl acrylate Ethyl 2-methylacetoacetate Ethyl Trifluoroacetoacetate

  • Ethyl4,4,-Trifluoroacetoacetate
  • Ethyltrifluoroacetoacetate,98+%
  • ETHYL 4,4,4-TRIFLUOROACETYLACETATE
  • ETFAA
  • 1-Ethoxy-4,4,4-trifluorobutane-1,3-dione
  • Ethyl 3-oxo-4,4,4-trifluorobutanoate
  • Ethyl 4,4,4-trifluoro-3-oxobutyrate
  • (Trifluoroacetyl)acetic acid ethyl ester
  • 2-(Trifluoroacetyl)acetic acid ethyl ester
  • 3-Oxo-4,4,4-trifluorobutanoic acid ethyl ester
  • 4,4,4-Trifluoro-3-oxobutyric acid ethyl ester
  • Trifluoroacetylacetic acid ethyl ester
  • Ethyl 4,4,4-trifluoroacetoacetate 98%
  • Ethyl4,4,4-trifluoroacetoacetate98%
  • Ethyl 4,4,4-trifluoroacetoacetate,Ethyl 3-oxo-4,4,4-trifluorobutyrate
  • Ethyl 4,4,4-trifluoro-3-oxobutanoate, 97%+
  • Ethyl 4,4,4-trifluoro-3-oxobutanoate, 95%+
  • ETHYL TRIFLUOROACETOACETATE 98%
  • Ethyl 4,4,4-trifluoroacetoacetate,97%
  • Ethyl 2-(trifluoroacethyl)acetate
  • 1-Ethoxy-4,4,4-trifluorobutane
  • ETHYL 3-OXO-4,4,4-TRIFLUOROACETOACETATE
  • ETHYL 3-OXO,4,4,4-TRIFLUOROBUTYRATE
  • ETHYL 4,4,4-TRIFLUOROACETOACETATE
  • ETHYL 4,4,4-TRIFLUOROACETOACTATE
  • ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE
  • ETHYL TRIFLUOROACETOACETATE
  • TIMTEC-BB SBB008825
  • 4,4,4-TRIFLUORO-3-OXOBUTANOIC ACID ETHYL ESTER
  • 4,4,4-TRIFLUOROACETOACETIC ACID ETHYL ESTER
  • AKOS B020306
  • 4,4,4-trifluoro-3-oxo-butanoicaciethylester
  • Acetoacetic acid, 4,4,4-trifluoro-, ethyl ester
  • Acetoacetic acid, 4-trifluoro-, ethyl ester
  • Butanoicacid,4,4,4-trifluoro-3-oxo-,ethylester
  • Ethyl (trifluoroacetyl)acetate
  • Ethyl gamma,gamma,gamma-trifluoroacetoacetate
  • Ethyl omega,omega,omega-trifluoroacetoacetate
  • Ethyl 4,4,4-trifluor
  • TRIFLUOROACETOACETIC ACID ETHYL ESTER
  • Ethyl 4,4,4-trifluoroacetocaetate
  • Ethyl 4,4,4-trifluoroaceto
  • 4,4,4- threefluorideethyl acetoacetate
  • Trifluoro ethyl acetoacetate
  • 4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (Ethyl trifluoroacetoacetate)
  • Ethyl 4,4,4-trifluoro-3-oxobutanoate, Ethyl 4,4,4-trifluoro-3-oxobutyrate
  • Ethyl 3-oxo-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-oxobutanoate 4,4,4-Trifluoroacetoacetic Acid Ethyl Ester
  • 4-trifluoroacetoacetate
  • Ethyl4,4,4-trifluoroacetoacetate (ETFAA)
  • 4,4,4-trifL
  • uoroacetoacetate
  • Ethyl 4,4,4-trifluoroacetoa
  • Ethyl-4,4,4-trifluoracetoacetat
  • 4,4,4-Ethyl trifluoroacetyl acetate
  • Ethyl 4,4,4-trifluoroacetoacetate?New
  • 372-31-6
  • 373-31-6
  • 371-31-6