ChemicalBook > CAS DataBase List > 4-Piperidinemethanol

4-Piperidinemethanol

Product Name
4-Piperidinemethanol
CAS No.
6457-49-4
Chemical Name
4-Piperidinemethanol
Synonyms
PIPERIDIN-4-YLMETHANOL;piperidin-4-ylmethanol hydrochloride;PiperidineMethanol;4-PIPERIDYLMETHANOL;4-(HYDROXYMETHYL)PIPERIDINE;55-59℃;BUTTPARK 27\08-74;4-piperdinemethanol;4-PIPERIDINEMETHANOL;4-Piperidinecarbinol
CBNumber
CB5710894
Molecular Formula
C6H13NO
Formula Weight
115.17
MOL File
6457-49-4.mol
More
Less

4-Piperidinemethanol Property

Melting point:
55-59 °C(lit.)
Boiling point:
118-120 °C10 mm Hg(lit.)
Density 
0,997 g/cm3
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Water Solubility 
Soluble in water
form 
Crystalline Powder, Chunks and/or Solid
pka
14.94±0.10(Predicted)
color 
White to off-white
Sensitive 
Hygroscopic
BRN 
103071
InChI
InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2
InChIKey
XBXHCBLBYQEYTI-UHFFFAOYSA-N
SMILES
N1CCC(CO)CC1
CAS DataBase Reference
6457-49-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
C,Xi
Risk Statements 
34-22
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
Hazard Note 
Irritant/Hygroscopic
HazardClass 
8
PackingGroup 
III
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
497312
Product name
4-Piperidinemethanol
Purity
97%
Packaging
5g
Price
$203
Updated
2025/07/31
Sigma-Aldrich
Product number
497312
Product name
4-Piperidinemethanol
Purity
97%
Packaging
25g
Price
$995
Updated
2025/07/31
TCI Chemical
Product number
P1653
Product name
4-Piperidinemethanol
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
P1653
Product name
4-Piperidinemethanol
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$239
Updated
2025/07/31
TRC
Product number
P481945
Product name
4-Piperidinemethanol
Packaging
10g
Price
$385
Updated
2021/12/16
More
Less

4-Piperidinemethanol Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder, chunks

Uses

4-Piperidinemethanol may be used in the preparation of:

  • N-tert-butoxycarbonyl-4-hydroxymethyl piperidine
  • desferrioxamine B (DFO) containing third generation triazine dendrimer
  • ethyl 3-(4-(hydroxymethyl)piperidin-1-yl)propanoate (EHMPP)
  • 4-(hydroxymethyl)piperidine-1-carbodithioic acid (HL)
  • 1-[[(1E)-2-(4-chlorophenyl)ethenyl]sulfonyl]-4-piperidinemethanol

General Description

4-Piperidinemethanol is a cyclic secondary amine. Its standard molar enthalpies of combustion, sublimation and formation have been determined.

Synthesis

1126-09-6

6457-49-4

The general procedure for the synthesis of 4-hydroxymethylpiperidine from ethyl 4-piperidinecarboxylate was as follows: lithium aluminum hydride (LiAlH4, 10.10 g, 0.266 mol) was suspended in tetrahydrofuran (THF, 150 mL) at 0 °C. Subsequently, a solution of ethyl 4-piperidinecarboxylate (18.13 g, 0.120 mol) dissolved in THF (300 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, it was cooled in an ice bath and a mixture of water (14 mL) and THF (28 mL) was slowly added. Next, a mixture of 15% aqueous sodium hydroxide (14 mL) and water (37 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was filtered to remove the precipitate and the filtrate was concentrated to give 17.88 g of the target product 4-hydroxymethylpiperidine in quantitative yield.

References

[1] Patent: WO2004/76450, 2004, A1. Location in patent: Page 59
[2] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 27
[3] RSC Advances, 2016, vol. 6, # 22, p. 17929 - 17940
[4] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[5] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 773 - 791

4-Piperidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 2-(4-Chloromethylpiperidin-1-yl)pyrimidine-5-carboxamide ,97% 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxamide 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate (2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl)methanol 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate 2-(4-(Hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide 1-Boc-4-(aminomethyl)piperidine Terfenadine Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate (1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)methanol
More
Less

4-Piperidinemethanol Suppliers

Americas 1 Belgium 3 China 310 Czech Republic 1 Europe 2 France 3 Germany 8 India 20 Ireland 1 Italy 2 Japan 4 Slovakia 1 Switzerland 4 Ukraine 2 United Kingdom 19 United States 46 Global 427
YuChen Biological Medicine
Tel
0535-7295056 15692356085
Email
sdycc1234@163.com
Country
China
ProdList
158
Advantage
58
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375892 15553111391
Email
3276840968@qq.com
Country
China
ProdList
301
Advantage
58
JIANGYIN RUISHIPHARM CO.,LIMITED
Tel
0510-0510-66227179 18921203887
Fax
+86-0510-66227179 QQ:2200317867
Email
sales@ruishipharm.com
Country
China
ProdList
749
Advantage
58
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084; 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
392
Advantage
60
BTC Pharmaceutical CO. Ltd
Tel
15716293042 18862996710
Fax
0513-68015394
Email
15050603958@163.com
Country
China
ProdList
695
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2802
Advantage
65
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Chem-Milestone Co., Ltd
Tel
021-50273253 13641951838
Fax
+86-21-61294436
Email
chemmilestone@163.com
Country
China
ProdList
151
Advantage
62
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
256
Advantage
55
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
21-33585366 13311639313
Fax
+86-21-34979012
Email
sales@shyrchem.com
Country
China
ProdList
806
Advantage
55
Candia Thamtech Company Limited
Tel
0371-86615086 18203638366 0371-86159066 13526786601
Fax
0371-86159066
Country
China
ProdList
2015
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Acesys Pharmatech
Tel
18860950986
Email
tangmanman@zenjipharma.com
Country
China
ProdList
1733
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1972
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
More
Less

View Lastest Price from 4-Piperidinemethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Piperidinemethanol 6457-49-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-13
Shaanxi Dideu Medichem Co. Ltd
Product
4-Piperidinemethanol 6457-49-4
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31
Henan Fengda Chemical Co., Ltd
Product
4-Piperidinemethanol 6457-49-4
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-17

6457-49-4, 4-PiperidinemethanolRelated Search:

2-Hydroxyethyl methacrylate Trimethylolpropane Triacetonediamine methylol cellulose 2,2,6,6-Tetramethyl-4-piperidinol 4-Piperidineethanol PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Hexahydroisonicotinamide Methyl 4-piperidinecarboxylate Methyl isonipecotate Ethyl 4-piperidinecarboxylate Isonipecotic acid 4,4-Piperidinediol hydrochloride Tris(hydroxymethyl)aminomethane Isonipecotic acid hydrochloride 3-Quinuclidinol hydrochloride Piperidine

  • 4-(Hydroxymethyl)piperidine, 98 % (NMR+TLC)
  • Piperidine-4-methanol
  • 4-Piperidinemethanol ,98%
  • piperidin-4-ylmethanol hydrochloride
  • 2-HydroMethyl piperidine
  • 4-PiperidineMethanol, 98% 5GR
  • 4-PiperidineMethanol or 4-(HydroxyMethyl)piperidine
  • PiperidineMethanol
  • 4-PiperidineMethanol 97%
  • 4-PiperidineMethanol, 97+%
  • China 4-Piperidinemethanol
  • (4-Piperidinyl)methanol
  • PIPERIDIN-4-YLMETHANOL
  • PIPERIDINEMETHANOL(4-)
  • 4-(HYDROXYMETHYL)PIPERIDINE
  • 4-PIPERIDINEMETHANOL
  • 4-PIPERIDYLMETHANOL
  • BUTTPARK 27\08-74
  • 4-Piperidinecarbinol
  • 4-Piperidine-methanol(4-(Hydroxymethyl)-piperidine)
  • 4-piperdinemethanol
  • 4-(Hydroxymethyl)piperidine 97%
  • 55-59℃
  • 4-PIPERIDINEMETHANOL 99.5+%
  • 4-HYDROXYMETHYLPIPERIDINE PIPERIDIN-4-YL-METHANOL
  • 4-Piperidine-methanol(4-(Hydroxymethyl)-piperi
  • 4-Piperidinemethanol&gt
  • 4- piperidinyl alcohol
  • 4-PIPERIDINEMETHANOL, PYPERIDINEMETHANOL
  • 4-Piperidinemethanol (6CI, 7CI, 9CI, ACI)
  • Butenafine Impurity 36
  • 4-Piperidinemethanol, 95%
  • 6457-49-4
  • Heterocyclic Building Blocks
  • Piperidines
  • Building Blocks
  • Piperidine Series
  • Pyrans, Piperidines & Piperazines
  • Alkohols
  • pharmacetical
  • PiperidineDerivative
  • Hydroxymethyl's
  • Pyrans, Piperidines &Piperazines
  • Piperidine
  • Alcohols and Derivatives
  • Amines and Anilines