BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

Product Name: BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
CAS No.: 159275-17-9
Chemical Name: BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Synonyms: BUTTPARK 95\50-67;1-CBZ-4-(BROMOMETHYL)PIPERIDINE;N-Cbz-4-(broMoMethyl)piperidine;4-(bromomethyl)piperidine-1-carboxylate;4-(Bromomethyl)piperidine, N-CBZ protected;benzyl 4-(broMoMethyl)piperidine-N-carboxylate;BENZYL 4-(BROMOMETHYL)PIPERIDINE-1-CARBOXYLATE;N-(BENZYLOXYCARBONYL)-4-(BROMOMETHYL)PIPERIDINE;N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine, 98 %;Benzyl 4-(bromoethyl)tetrahydro-1(2H)-pyridinecarboxylate
CBNumber: CB0136222
Molecular Formula: C14H18BrNO2
Formula Weight: 312.2
MOL File: 159275-17-9.mol

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BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property

Melting point:: 68 °C
Boiling point:: 403.4±28.0 °C(Predicted)
Density: 1.356±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
pka: -1.96±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C14H18BrNO2/c15-10-12-6-8-16(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,12H,6-11H2
InChIKey: XJHKDSZGAWXUTB-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC(CBr)CC1
CAS DataBase Reference: 159275-17-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
Safety Statements: 26-36/37/39-45
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B233410
Product name: Benzyl4-(bromomethyl)tetrahydro-1(2h)-pyridinecarboxylate
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144283
Product name: Benzyl 4-(bromomethyl)piperidine-1-carboxylate
Packaging: 250mg
Price: $72.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144283
Product name: Benzyl 4-(bromomethyl)piperidine-1-carboxylate
Packaging: 500mg
Price: $125
Updated: 2021/12/16

Apolloscientific

Product number: OR23105
Product name: 4-(Bromomethyl)piperidine,N-CBZprotected
Purity: 98%
Packaging: 1g
Price: $148
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-V0
Product name: 4-(Bromomethyl)piperidine, N-Cbz protected
Purity: 98%
Packaging: 1g
Price: $164
Updated: 2021/12/16

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BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production

Synthesis

122860-33-7

159275-17-9

Under nitrogen atmosphere, benzyl 4-(hydroxymethyl)piperidine-1-carboxylate (10 g, 40.11 mmol) was added to a 500 mL three-necked round-bottomed flask, dissolved in dichloromethane (100 mL), and the mixture was cooled to 0 °C. Subsequently, a solution of triphenylphosphine (13.7 g, 52.14 mmol) in dichloromethane (50 mL) was slowly added to the reaction mixture and kept stirring at 0°C for 20 minutes. Next, a dichloromethane (50 mL) solution of carbon tetrabromide (16 g, 48.13 mmol) was added and the reaction mixture was brought to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with deionized water. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, purification by column chromatography afforded benzyl 4-(bromomethyl)piperidine-1-carboxylate (10 g).

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 10, p. 3586 - 3604
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 13, p. 2606 - 2620
[3] Patent: WO2015/195950, A1. Location in patent: Page/Page column 82
[3] Patent: , 2015, . Location in patent: Page/Page column 82

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

4-Piperidinemethanol Tetrahydrofuran Sulfuryl chloride Isonipecotic acid Benzyl chloroformate Carbon tetrabromide Methanol Sodium hydroxide Phosphorus tribromide Lithium borohydride Triphenylphosphine

Preparation Products

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BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Suppliers

Belgium 1 China 81 France 2 Germany 3 India 1 United Kingdom 9 United States 24 Global 121

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View Lastest Price from BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 159275-17-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Career Henan Chemical Co

Product: BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 159275-17-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-25

159275-17-9, BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATERelated Search:

Benzyl formate BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE BENZYL (4-BROMOBUTYL)CARBAMATE

N-(BENZYLOXYCARBONYL)-4-(BROMOMETHYL)PIPERIDINE

BENZYL 4-(BROMOMETHYL)PIPERIDINE-1-CARBOXYLATE

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

BUTTPARK 95\50-67

Benzyl 4-(bromoethyl)tetrahydro-1(2H)-pyridinecarboxylate

4-(Bromomethyl)piperidine, N-CBZ protected

N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine, 98 %

1-CBZ-4-(BROMOMETHYL)PIPERIDINE

Benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate ,97%

benzyl 4-(broMoMethyl)piperidine-N-carboxylate

1-Piperidinecarboxylic acid, 4-(broMoMethyl)-, phenylMethyl ester

N-Cbz-4-(broMoMethyl)piperidine

4-(bromomethyl)piperidine-1-carboxylate

159275-17-9

C14H18BrNO2

ALKYL HALIDE

Methyl Halides

Pyrans, Piperidines & Piperazines

Methyl Halides

Pyrans, Piperidines &Piperazines

Piperidine

API intermediates

Halides

Heterocycles