BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- Product Name
- BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- CAS No.
- 159275-17-9
- Chemical Name
- BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- Synonyms
- BUTTPARK 95\50-67;1-CBZ-4-(BROMOMETHYL)PIPERIDINE;N-Cbz-4-(broMoMethyl)piperidine;4-(bromomethyl)piperidine-1-carboxylate;4-(Bromomethyl)piperidine, N-CBZ protected;benzyl 4-(broMoMethyl)piperidine-N-carboxylate;BENZYL 4-(BROMOMETHYL)PIPERIDINE-1-CARBOXYLATE;N-(BENZYLOXYCARBONYL)-4-(BROMOMETHYL)PIPERIDINE;N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine, 98 %;Benzyl 4-(bromoethyl)tetrahydro-1(2H)-pyridinecarboxylate
- CBNumber
- CB0136222
- Molecular Formula
- C14H18BrNO2
- Formula Weight
- 312.2
- MOL File
- 159275-17-9.mol
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property
- Melting point:
- 68 °C
- Boiling point:
- 403.4±28.0 °C(Predicted)
- Density
- 1.356±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- -1.96±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C14H18BrNO2/c15-10-12-6-8-16(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,12H,6-11H2
- InChIKey
- XJHKDSZGAWXUTB-UHFFFAOYSA-N
- SMILES
- N1(C(OCC2=CC=CC=C2)=O)CCC(CBr)CC1
- CAS DataBase Reference
- 159275-17-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38-34
- Safety Statements
- 26-36/37/39-45
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B233410
- Product name
- Benzyl4-(bromomethyl)tetrahydro-1(2h)-pyridinecarboxylate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB144283
- Product name
- Benzyl 4-(bromomethyl)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $72.5
- Updated
- 2021/12/16
- Product number
- FB144283
- Product name
- Benzyl 4-(bromomethyl)piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- OR23105
- Product name
- 4-(Bromomethyl)piperidine,N-CBZprotected
- Purity
- 98%
- Packaging
- 1g
- Price
- $148
- Updated
- 2021/12/16
- Product number
- 4H56-9-V0
- Product name
- 4-(Bromomethyl)piperidine, N-Cbz protected
- Purity
- 98%
- Packaging
- 1g
- Price
- $164
- Updated
- 2021/12/16
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production
Synthesis
122860-33-7
159275-17-9
Under nitrogen atmosphere, benzyl 4-(hydroxymethyl)piperidine-1-carboxylate (10 g, 40.11 mmol) was added to a 500 mL three-necked round-bottomed flask, dissolved in dichloromethane (100 mL), and the mixture was cooled to 0 °C. Subsequently, a solution of triphenylphosphine (13.7 g, 52.14 mmol) in dichloromethane (50 mL) was slowly added to the reaction mixture and kept stirring at 0°C for 20 minutes. Next, a dichloromethane (50 mL) solution of carbon tetrabromide (16 g, 48.13 mmol) was added and the reaction mixture was brought to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with deionized water. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, purification by column chromatography afforded benzyl 4-(bromomethyl)piperidine-1-carboxylate (10 g).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 10, p. 3586 - 3604
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 13, p. 2606 - 2620
[3] Patent: WO2015/195950, A1. Location in patent: Page/Page column 82
[3] Patent: , 2015, . Location in patent: Page/Page column 82
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Suppliers
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View Lastest Price from BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE manufacturers
- Product
- BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 159275-17-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10
- Product
- BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 159275-17-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-25