ChemicalBook > CAS DataBase List > BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

Product Name
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
CAS No.
159275-17-9
Chemical Name
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Synonyms
BUTTPARK 95\50-67;1-CBZ-4-(BROMOMETHYL)PIPERIDINE;N-Cbz-4-(broMoMethyl)piperidine;4-(bromomethyl)piperidine-1-carboxylate;4-(Bromomethyl)piperidine, N-CBZ protected;benzyl 4-(broMoMethyl)piperidine-N-carboxylate;BENZYL 4-(BROMOMETHYL)PIPERIDINE-1-CARBOXYLATE;N-(BENZYLOXYCARBONYL)-4-(BROMOMETHYL)PIPERIDINE;N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine, 98 %;Benzyl 4-(bromoethyl)tetrahydro-1(2H)-pyridinecarboxylate
CBNumber
CB0136222
Molecular Formula
C14H18BrNO2
Formula Weight
312.2
MOL File
159275-17-9.mol
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BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property

Melting point:
68 °C
Boiling point:
403.4±28.0 °C(Predicted)
Density 
1.356±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, stored under nitrogen
pka
-1.96±0.40(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C14H18BrNO2/c15-10-12-6-8-16(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,12H,6-11H2
InChIKey
XJHKDSZGAWXUTB-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC(CBr)CC1
CAS DataBase Reference
159275-17-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-34
Safety Statements 
26-36/37/39-45
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
B233410
Product name
Benzyl4-(bromomethyl)tetrahydro-1(2h)-pyridinecarboxylate
Packaging
250mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144283
Product name
Benzyl 4-(bromomethyl)piperidine-1-carboxylate
Packaging
250mg
Price
$72.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144283
Product name
Benzyl 4-(bromomethyl)piperidine-1-carboxylate
Packaging
500mg
Price
$125
Updated
2021/12/16
Apolloscientific
Product number
OR23105
Product name
4-(Bromomethyl)piperidine,N-CBZprotected
Purity
98%
Packaging
1g
Price
$148
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-9-V0
Product name
4-(Bromomethyl)piperidine, N-Cbz protected
Purity
98%
Packaging
1g
Price
$164
Updated
2021/12/16
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BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production

Synthesis

122860-33-7

159275-17-9

Under nitrogen atmosphere, benzyl 4-(hydroxymethyl)piperidine-1-carboxylate (10 g, 40.11 mmol) was added to a 500 mL three-necked round-bottomed flask, dissolved in dichloromethane (100 mL), and the mixture was cooled to 0 °C. Subsequently, a solution of triphenylphosphine (13.7 g, 52.14 mmol) in dichloromethane (50 mL) was slowly added to the reaction mixture and kept stirring at 0°C for 20 minutes. Next, a dichloromethane (50 mL) solution of carbon tetrabromide (16 g, 48.13 mmol) was added and the reaction mixture was brought to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with deionized water. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, purification by column chromatography afforded benzyl 4-(bromomethyl)piperidine-1-carboxylate (10 g).

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 10, p. 3586 - 3604
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 13, p. 2606 - 2620
[3] Patent: WO2015/195950, A1. Location in patent: Page/Page column 82
[3] Patent: , 2015, . Location in patent: Page/Page column 82

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

4-Piperidinemethanol Tetrahydrofuran Sulfuryl chloride Isonipecotic acid Benzyl chloroformate Carbon tetrabromide Methanol Sodium hydroxide Phosphorus tribromide Lithium borohydride Triphenylphosphine

Preparation Products

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View Lastest Price from BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 159275-17-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Career Henan Chemical Co
Product
BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 159275-17-9
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-25

159275-17-9, BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATERelated Search:

Benzyl formate BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE BENZYL (4-BROMOBUTYL)CARBAMATE

  • N-(BENZYLOXYCARBONYL)-4-(BROMOMETHYL)PIPERIDINE
  • BENZYL 4-(BROMOMETHYL)PIPERIDINE-1-CARBOXYLATE
  • BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
  • BUTTPARK 95\50-67
  • Benzyl 4-(bromoethyl)tetrahydro-1(2H)-pyridinecarboxylate
  • 4-(Bromomethyl)piperidine, N-CBZ protected
  • N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine, 98 %
  • 1-CBZ-4-(BROMOMETHYL)PIPERIDINE
  • Benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate ,97%
  • benzyl 4-(broMoMethyl)piperidine-N-carboxylate
  • 1-Piperidinecarboxylic acid, 4-(broMoMethyl)-, phenylMethyl ester
  • N-Cbz-4-(broMoMethyl)piperidine
  • 4-(bromomethyl)piperidine-1-carboxylate
  • 159275-17-9
  • C14H18BrNO2
  • ALKYL HALIDE
  • Methyl Halides
  • Pyrans, Piperidines & Piperazines
  • Methyl Halides
  • Pyrans, Piperidines &Piperazines
  • Piperidine
  • API intermediates
  • Halides
  • Heterocycles