ChemicalBook > CAS DataBase List > 4-Benzylpiperidine

4-Benzylpiperidine

Product Name
4-Benzylpiperidine
CAS No.
31252-42-3
Chemical Name
4-Benzylpiperidine
Synonyms
NSC 30346;AKOS BBS-00003617;4-Benzylpiperdine;4-benzyl-piperidin;4-BENZYLPIPERIDINE;4-Benzylpiperidine99%;Piperidine, 4-benzyl-;LABOTEST-BB LTBB000752;4-Benzylpiperidine,98%;4-Benzylpiperidine >
CBNumber
CB9141122
Molecular Formula
C12H17N
Formula Weight
175.27
MOL File
31252-42-3.mol
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4-Benzylpiperidine Property

Melting point:
6-7 °C (lit.)
Boiling point:
279 °C (lit.)
Density 
0.997 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.537(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
form 
Viscous Liquid
pka
10.58±0.10(Predicted)
color 
Clear colorless to yellow
BRN 
132339
CAS DataBase Reference
31252-42-3(CAS DataBase Reference)
EPA Substance Registry System
Piperidine, 4-(phenylmethyl)- (31252-42-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TM4728000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
142360
Product name
4-Benzylpiperidine
Purity
99%
Packaging
25g
Price
$57.2
Updated
2024/03/01
TCI Chemical
Product number
B0387
Product name
4-Benzylpiperidine
Purity
>99.0%(GC)
Packaging
25mL
Price
$32
Updated
2022/04/27
TCI Chemical
Product number
B0387
Product name
4-Benzylpiperidine
Purity
>99.0%(GC)
Packaging
250mL
Price
$198
Updated
2021/12/16
Alfa Aesar
Product number
B23883
Product name
4-Benzylpiperidine, 98%
Packaging
100g
Price
$91.3
Updated
2021/12/16
Alfa Aesar
Product number
B23883
Product name
4-Benzylpiperidine, 98%
Packaging
25g
Price
$34.1
Updated
2021/12/16
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4-Benzylpiperidine Chemical Properties,Usage,Production

Chemical Properties

clear colourless to yellow viscous liquid.

Uses

4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.

Preparation

4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

Application

Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Synthesis Reference(s)

Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196

General Description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

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4-Benzylpiperidine Suppliers

Shaanxi Didu New Material Co., Ltd
Tel
029-81145920 15353716720
Email
1046@dideu.com
Country
China
ProdList
10003
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9414
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
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View Lastest Price from 4-Benzylpiperidine manufacturers

Shanghai CRM New Material Technology Co., LTD
Product
4-benzylpiperidine 31252-42-3
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
2546245
Release date
2022-09-23
Shaanxi Dideu Medichem Co. Ltd
Product
4-Benzylpiperidine 31252-42-3
Price
US $0.00-0.00/Kg
Min. Order
100G
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-17
Career Henan Chemical Co
Product
4-BENZYLPIPERIDINE 31252-42-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-02

31252-42-3, 4-BenzylpiperidineRelated Search:


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