4-Benzylpiperidine
- Product Name
- 4-Benzylpiperidine
- CAS No.
- 31252-42-3
- Chemical Name
- 4-Benzylpiperidine
- Synonyms
- NSC 30346;AKOS BBS-00003617;4-Benzylpiperdine;4-benzyl-piperidin;4-BENZYLPIPERIDINE;4-Benzylpiperidine99%;Piperidine, 4-benzyl-;LABOTEST-BB LTBB000752;4-Benzylpiperidine,98%;4-Benzylpiperidine >
- CBNumber
- CB9141122
- Molecular Formula
- C12H17N
- Formula Weight
- 175.27
- MOL File
- 31252-42-3.mol
4-Benzylpiperidine Property
- Melting point:
- 6-7 °C (lit.)
- Boiling point:
- 279 °C (lit.)
- Density
- 0.997 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.537(lit.)
- Flash point:
- >230 °F
- storage temp.
- Store below +30°C.
- form
- Viscous Liquid
- pka
- 10.58±0.10(Predicted)
- color
- Clear colorless to yellow
- BRN
- 132339
- CAS DataBase Reference
- 31252-42-3(CAS DataBase Reference)
- EPA Substance Registry System
- Piperidine, 4-(phenylmethyl)- (31252-42-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 142360
- Product name
- 4-Benzylpiperidine
- Purity
- 99%
- Packaging
- 25g
- Price
- $57.2
- Updated
- 2024/03/01
- Product number
- B0387
- Product name
- 4-Benzylpiperidine
- Purity
- >99.0%(GC)
- Packaging
- 25mL
- Price
- $32
- Updated
- 2022/04/27
- Product number
- B0387
- Product name
- 4-Benzylpiperidine
- Purity
- >99.0%(GC)
- Packaging
- 250mL
- Price
- $198
- Updated
- 2021/12/16
- Product number
- B23883
- Product name
- 4-Benzylpiperidine, 98%
- Packaging
- 100g
- Price
- $91.3
- Updated
- 2021/12/16
- Product number
- B23883
- Product name
- 4-Benzylpiperidine, 98%
- Packaging
- 25g
- Price
- $34.1
- Updated
- 2021/12/16
4-Benzylpiperidine Chemical Properties,Usage,Production
Chemical Properties
clear colourless to yellow viscous liquid.
Uses
4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.
Preparation
4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.
Application
Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution
Synthesis Reference(s)
Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196
General Description
4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.
Biochem/physiol Actions
4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.
4-Benzylpiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Benzylpiperidine manufacturers
- Product
- 4-benzylpiperidine 31252-42-3
- Price
- US $10.00-15.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 2546245
- Release date
- 2022-09-23
- Product
- 4-Benzylpiperidine 31252-42-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 100G
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-17
- Product
- 4-BENZYLPIPERIDINE 31252-42-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02