4-Benzylpiperidine

ChemicalBook > CAS DataBase List > 4-Benzylpiperidine

Product Name: 4-Benzylpiperidine
CAS No.: 31252-42-3
Chemical Name: 4-Benzylpiperidine
Synonyms: NSC 30346;AKOS BBS-00003617;4-Benzylpiperdine;4-benzyl-piperidin;4-BENZYLPIPERIDINE;4-Benzylpiperidine99%;Piperidine, 4-benzyl-;LABOTEST-BB LTBB000752;4-Benzylpiperidine,98%;4-Benzylpiperidine >
CBNumber: CB9141122
Molecular Formula: C12H17N
Formula Weight: 175.27
MOL File: 31252-42-3.mol

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4-Benzylpiperidine Property

Melting point:: 6-7 °C (lit.)
Boiling point:: 279 °C (lit.)
Density: 0.997 g/mL at 25 °C (lit.)
refractive index: n20/D 1.537(lit.)
Flash point:: >230 °F
storage temp.: Store below +30°C.
form: Viscous Liquid
pka: 10.58±0.10(Predicted)
color: Clear colorless to yellow
BRN: 132339
CAS DataBase Reference: 31252-42-3(CAS DataBase Reference)
EPA Substance Registry System: Piperidine, 4-(phenylmethyl)- (31252-42-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: TM4728000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 142360
Product name: 4-Benzylpiperidine
Purity: 99%
Packaging: 25g
Price: $57.2
Updated: 2024/03/01

TCI Chemical

Product number: B0387
Product name: 4-Benzylpiperidine
Purity: >99.0%(GC)
Packaging: 25mL
Price: $32
Updated: 2022/04/27

TCI Chemical

Product number: B0387
Product name: 4-Benzylpiperidine
Purity: >99.0%(GC)
Packaging: 250mL
Price: $198
Updated: 2021/12/16

Alfa Aesar

Product number: B23883
Product name: 4-Benzylpiperidine, 98%
Packaging: 100g
Price: $91.3
Updated: 2021/12/16

Alfa Aesar

Product number: B23883
Product name: 4-Benzylpiperidine, 98%
Packaging: 25g
Price: $34.1
Updated: 2021/12/16

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4-Benzylpiperidine Chemical Properties,Usage,Production

Chemical Properties

clear colourless to yellow viscous liquid.

Uses

4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.

Preparation

4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

Application

Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Synthesis Reference(s)

Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196

General Description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

4-Benzylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Benzylpiperidine Suppliers

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View Lastest Price from 4-Benzylpiperidine manufacturers

Shanghai CRM New Material Technology Co., LTD

Product: 4-benzylpiperidine 31252-42-3
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 2546245
Release date: 2022-09-23

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Benzylpiperidine 31252-42-3
Price: US $0.00-0.00/Kg
Min. Order: 100G
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-17

Career Henan Chemical Co

Product: 4-BENZYLPIPERIDINE 31252-42-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-02

31252-42-3, 4-BenzylpiperidineRelated Search:

4-(4-FLUOROBENZOYL)PIPERIDINE P-TOLUENESULFONATE KETANSERIN TARTRATE 4-(4-Fluorobenzoyl)piperidine hydrochloride PIRENPERONE (4-METHOXYPHENYL)(4-PIPERIDYL)METHANONE HYDROCHLORIDE 4-BENZYL-4-HYDROXYPIPERIDINE alpha,alpha-Diphenyl-4-piperidinomethanol Ifenprodil Terfenadine 4-BENZOYLPIPERIDINE HYDROCHLORIDE BENZETIMIDE Diphenylpiperidin-4-ylmethanol hydrochloride Ketanserin 4-Benzylpiperidine 1-(2-Aminoethyl)-4-benzylpiperidine METHYL 1-BENZYL-PIPERIDINE-3-CARBOXYLATE 4-(3-TRIFLUOROMETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE

4-(phenylmethyl)-piperidin

4-benzyl-piperidin

LABOTEST-BB LTBB000752

PHENYL(4-PIPERIDYL)METHANE

Piperidine, 4-(phenylmethyl)-

Piperidine, 4-benzyl-

4-BENZYLPIPERIDINE

4-(PHENYLMETHYL)PIPERIDINE

ALPHA-(4-PIPERIDYL)TOLUENE

AKOS BBS-00003617

4-Benzylpiperidine99%

4-Benzylpiperidine,98%

4-Benzylpiperdine

NSC 30346

4-Benzylpiperidine,4-(phenylMethyl)piperidine

alpha-(Piperidin-4-yl)toluene

4-Benzylpiperidine, 98% 5GR

4-BENZYLPIPERIDINE FOR SYNTHESIS

4-(Phenylmethyl)piperidine, [(Piperidin-4-yl)methyl]benzene

4-Benzylpiperidine &gt

4-Benzylpiperidine USP/EP/BP

31252-42-3

31252-42-4

31252-42-0

C12H18N

Heterocyclic Building Blocks

Piperidines

Building Blocks

Bioactive Small Molecules

Building Blocks

C12

Cell Biology

Chemical Synthesis

Heterocyclic Building Blocks

Piperidines

Piperidine

Piperidine Series