alpha,alpha-Diphenyl-4-piperidinomethanol
- Product Name
- alpha,alpha-Diphenyl-4-piperidinomethanol
- CAS No.
- 115-46-8
- Chemical Name
- alpha,alpha-Diphenyl-4-piperidinomethanol
- Synonyms
- AZACYCLONOL;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL;Azacyclanol;alpha,alpha-diphenyl-4-piperidinemethano;mer17;MER 17;Calmeran;Frenquel;Frenoton;MDL 4829
- CBNumber
- CB3146211
- Molecular Formula
- C18H21NO
- Formula Weight
- 267.37
- MOL File
- 115-46-8.mol
alpha,alpha-Diphenyl-4-piperidinomethanol Property
- Melting point:
- 160-163 °C
- Boiling point:
- 410.55°C (rough estimate)
- Density
- 1.0449 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5100 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- Chloroform, Methanol (Slightly, Sonicated)
- pka
- 13.32±0.29(Predicted)
- form
- Solid
- color
- White to light beige
- InChIKey
- ZMISODWVFHHWNR-UHFFFAOYSA-N
- CAS DataBase Reference
- 115-46-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Azacyclonol(115-46-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 8.14973
- Product name
- Diphenyl-4-piperidinemethanol
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $121
- Updated
- 2024/03/01
- Product number
- P1369
- Product name
- α-(4-Piperidyl)benzhydrol
- Purity
- >99.0%(GC)(T)
- Packaging
- 5g
- Price
- $39
- Updated
- 2024/03/01
- Product number
- P1369
- Product name
- α-(4-Piperidyl)benzhydrol
- Purity
- >99.0%(GC)(T)
- Packaging
- 25g
- Price
- $123
- Updated
- 2024/03/01
- Product number
- H61281
- Product name
- Diphenyl(4-piperidinyl)methanol, 95%
- Packaging
- 25g
- Price
- $70.9
- Updated
- 2021/12/16
- Product number
- H61281
- Product name
- Diphenyl(4-piperidinyl)methanol, 95%
- Packaging
- 100g
- Price
- $219
- Updated
- 2021/12/16
alpha,alpha-Diphenyl-4-piperidinomethanol Chemical Properties,Usage,Production
Description
alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.
Chemical Properties
α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.
Originator
Frenquel,Merrell,US,1955
Uses
Anxiolytic;H1 antagonist
Uses
α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.
Definition
ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment
with ammonia and when so obtained has a melting point of 160-161°C.
brand name
Frenquel (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
alpha,alpha-Diphenyl-4-piperidinomethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from alpha,alpha-Diphenyl-4-piperidinomethanol manufacturers
- Product
- Azacyclonol 115-46-8
- Price
- US $10.00-15.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10t
- Release date
- 2022-09-21
- Product
- alpha,alpha-Diphenyl-4-piperidinomethanol 115-46-8
- Price
- US $26.00/g
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-12-13
- Product
- alpha,alpha-Diphenyl-4-piperidinomethanol 115-46-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-22