alpha,alpha-Diphenyl-4-piperidinomethanol

ChemicalBook > CAS DataBase List > alpha,alpha-Diphenyl-4-piperidinomethanol

alpha,alpha-Diphenyl-4-piperidinomethanol

Product Name: alpha,alpha-Diphenyl-4-piperidinomethanol
CAS No.: 115-46-8
Chemical Name: alpha,alpha-Diphenyl-4-piperidinomethanol
Synonyms: AZACYCLONOL;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL;Azacyclanol;alpha,alpha-diphenyl-4-piperidinemethano;mer17;MER 17;Calmeran;Frenquel;Frenoton;MDL 4829
CBNumber: CB3146211
Molecular Formula: C18H21NO
Formula Weight: 267.37
MOL File: 115-46-8.mol

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alpha,alpha-Diphenyl-4-piperidinomethanol Property

Melting point:: 160-163 °C
Boiling point:: 410.55°C (rough estimate)
Density: 1.0449 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.5100 (estimate)
storage temp.: Store below +30°C.
solubility: Chloroform, Methanol (Slightly, Sonicated)
pka: 13.32±0.29(Predicted)
form: Solid
color: White to light beige
InChIKey: ZMISODWVFHHWNR-UHFFFAOYSA-N
CAS DataBase Reference: 115-46-8(CAS DataBase Reference)
NIST Chemistry Reference: Azacyclonol(115-46-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25
WGK Germany: WGK 3 highly water endangering
RTECS: TN0470000
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.14973
Product name: Diphenyl-4-piperidinemethanol
Purity: for synthesis
Packaging: 25g
Price: $121
Updated: 2024/03/01

TCI Chemical

Product number: P1369
Product name: α-(4-Piperidyl)benzhydrol
Purity: >99.0%(GC)(T)
Packaging: 5g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: P1369
Product name: α-(4-Piperidyl)benzhydrol
Purity: >99.0%(GC)(T)
Packaging: 25g
Price: $123
Updated: 2024/03/01

Alfa Aesar

Product number: H61281
Product name: Diphenyl(4-piperidinyl)methanol, 95%
Packaging: 25g
Price: $70.9
Updated: 2021/12/16

Alfa Aesar

Product number: H61281
Product name: Diphenyl(4-piperidinyl)methanol, 95%
Packaging: 100g
Price: $219
Updated: 2021/12/16

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alpha,alpha-Diphenyl-4-piperidinomethanol Chemical Properties,Usage,Production

Description

alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.

Chemical Properties

α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.

Originator

Frenquel,Merrell,US,1955

Uses

Anxiolytic;H1 antagonist

Uses

α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.

Definition

ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.

Manufacturing Process

A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours. The solution is filtered and the filtrate evaprated under reduced pressure. The residue is dissolved in a mixture of equal parts of methanol and butanone and 0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283- 285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C.

brand name

Frenquel (Marion Merrell Dow).

Therapeutic Function

Tranquilizer

alpha,alpha-Diphenyl-4-piperidinomethanol Preparation Products And Raw materials

Raw materials

Preparation Products

Terfenadine

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View Lastest Price from alpha,alpha-Diphenyl-4-piperidinomethanol manufacturers

Shanghai CRM New Material Technology Co., LTD

Product: Azacyclonol 115-46-8
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-21

Qiuxian Baitai New Material Co., LTD

Product: alpha,alpha-Diphenyl-4-piperidinomethanol 115-46-8
Price: US $26.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-12-13

Dideu Industries Group Limited

Product: alpha,alpha-Diphenyl-4-piperidinomethanol 115-46-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-22

115-46-8, alpha,alpha-Diphenyl-4-piperidinomethanolRelated Search:

Chlorodiphenylphosphine α-Lipoic Acid Diphenylthiocarbazide 1,3-Diphenyl-2-thiourea Dithizone 4-Aminobutyric acid Diethylstilbestrol 1,5-Diphenylcarbazide Biphenyl 4-Piperidinemethanol Dichlorodiphenylsilane Diphenyldimethoxysilane Diphenyl-2-pyridylphosphine ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL, HYDROCHLORIDE,ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL HCL Terfenadine Ethyl 4-{4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl}-alpha,alpha-dimethylbenzeneacetate hydrochloride TERFENADINE IMP.I (EP):DIPHENYL(PIPERIDIN-4-YLMETHANOL(AZACYCLONOL) Fexofenadine hydrochloride

TIMTEC-BB SBB003057

4-Piperidinemethanol, alpha,alpha-diphenyl-

alpha,alpha-diphenyl-4-piperidinemethano

Ataractan

Azacyklonol

Calmeran

Diphenyl(4-piperidinyl)methanol

Diphenyl-4-piperidylmethanol

Frenoton

Frenquel

MER 17

mer17

Azacyclonol (base and/or unspecified salts)

AZACYCLONOL (ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL)

4-[Hydroxy(diphenyl)methyl]piperidine

Diphenyl(piperidin-4-yl)methanol, Azacyclonol, alpha-(Piperidin-4-yl)benzhydrol

α-(4-Piperidyl)benzhydrol

alpha,alpha-Diphenyl-4-piperidinoMethanol, 98+% 5GR

4-(DiphenylhydroxyMethyl)piperidine

MDL 4829

DIPHENYL-4-PIPERIDINEMETHANOL FOR SYNTHE

a-(4-Piperidyl)benzhydrol

Psychosa

α,α-Diphenyl-4-piperidinomethanol

a, a- Azacyclonol

4-PiperidineMethanol, a,a-diphenyl-

phenyl(4-(piperidin-1-yl)phenyl)methanol

ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE METHONOL

Diphenyl-4-piperidinemethanol for synthesis

α, α-Diphenyl-4-piperidinomethanol, 98+%

Fexofenadine hydrochloride impurity E (EP)

Fexofenadine EP Impurity E

Terfenadine Impurity 1

Psychosan

Azacyclonol Base

AzacyclonolBase98%

ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL

ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL

ALPHA-(4-PIPERIDYL)BENZHYDROL

A,A-DIPHENYL-4-PIPERIDINEMETHANOL

4-(ALPHA,ALPHA DIPHENYL) PIPERIDINE METHANOL

2,2-DIPHENYL-4-PIPERIDONOMETHANOL

AZACYCLONAL

AZACYCLONOL

DIPHENYL-4-PIPERIDINEMETHANOL

DIPHENYL-PIPERIDIN-4-YL-METHANOL

gamma-pipradol

α,α-Diphenyl-4-piperidinylcarbinol

alpha,alpha-Diphenyl-4-piperidinomethanol, 98+%

alpha,alpha-Diphenyl-4-piperid

AZACYCLONOL A , A -DIPHENYL-4-PIPERIDINEMETHANOL

Fexofenadine Related Compound E

ALPHA ALPHA -DIPHENYL-4-PIPERDINEMETHANO L

Fexofenadine Impurity 5（Fexofenadine EP Impurity E）

ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE

α-(4-Piperidyl)benzhydrol&gt

Diphenyl(piperidin-4-yl)methanol (A

4-Piperidinemethanol, α,α-diphenyl-