KETANSERIN TARTRATE

Product Name: KETANSERIN TARTRATE
CAS No.: 83846-83-7
Chemical Name: KETANSERIN TARTRATE
Synonyms: kjk-945;R 41468;R41468 tartrate;Ketanserin Tartrat;Ketanserinetartrate;KETANSERIN TARTRATE;R 41468 TARTRATE SALT;quinazoline-2,4(1H,3H);KETANSERIN TARTRATE SALT;3-(2-(4-(4-Fluorobenzoyl)
CBNumber: CB8415888
Molecular Formula: C26H28FN3O9
Formula Weight: 545.52
MOL File: 83846-83-7.mol

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KETANSERIN TARTRATE Property

Melting point:: 183～186℃
storage temp.: 2-8°C
solubility: ethanol: 3.3mg/mL
form: solid
color: white
Water Solubility: Soluble to 10 mM in water
CAS DataBase Reference: 83846-83-7(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: VA1411195
HazardClass: 6.1
HS Code: 29335990
Toxicity: LD50 oral in rat: 129mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S006
Product name: Ketanserin (+)-tartrate salt
Purity: ≥97%, solid
Packaging: 10mg
Price: $90.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: S006
Product name: Ketanserin (+)-tartrate salt
Purity: ≥97%, solid
Packaging: 50mg
Price: $272.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.06271
Product name: Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem
Packaging: 50MG
Price: $111
Updated: 2025/07/31

Cayman Chemical

Product number: 22058
Product name: Ketanserin (tartrate)
Purity: ≥98%
Packaging: 50mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 22058
Product name: Ketanserin (tartrate)
Purity: ≥98%
Packaging: 100mg
Price: $152
Updated: 2024/03/01

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KETANSERIN TARTRATE Chemical Properties,Usage,Production

Description

Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT₂ (IC₅₀ = 6.3 nM; K_i = 2.1 nM). It has no activity at 5-HT₁ receptors but does have activity at histamine type 1, α₁-adrenergic, and dopamine receptors with K_i values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.

Uses

coccidiostat

Uses

Selective 5-HT2A serotonin receptor antagonist

Biological Activity

Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes.

Biochem/physiol Actions

Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.

storage

Room temperature

References

[1] J.E. LEYSEN. Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors[J]. Life sciences, 1981, 28 9: Pages 1015-1022. DOI: 10.1016/0024-3205(81)90747-5
[2] J M VAN NUETEN. Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1981, 218 1: 217-230.
[3] WEN-MIN DU. Effects of long-term treatment with ketanserin on blood pressure variability and end-organ damage in spontaneously hypertensive rats.[J]. Journal of Cardiovascular Pharmacology, 2003, 41 2: 233-239. DOI: 10.1097/00005344-200302000-00012
[4] SEBASTIAAN W. NIJ BIJVANK . Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial[J]. European journal of obstetrics, gynecology, and reproductive biology, 2015, 189: Pages 106-111. DOI: 10.1016/j.ejogrb.2015.02.002

KETANSERIN TARTRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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KETANSERIN TARTRATE Suppliers

China 136 Europe 1 Germany 2 India 1 Switzerland 2 United Kingdom 8 United States 17 Global 167

J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Chembest Research Laboratories Limited

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Ascent Scientific

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Jia Xing Isenchem Co.,Ltd

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Syntechem Co.,Ltd

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Dalian Meilun Biotech Co., Ltd.

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View Lastest Price from KETANSERIN TARTRATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ketanserin tartrate 83846-83-7
Price: US $0.00/Kg/Bag
Min. Order: 10g
Purity: 99%min
Supply Ability: 10kg
Release date: 2021-08-14

Henan Bao Enluo International TradeCo.，LTD

Product: KETANSERIN TARTRATE 83846-83-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-06-19

Hebei Zhanyao Biotechnology Co. Ltd

Product: Ketanserin Tartrate 83846-83-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/month
Release date: 2021-03-31

83846-83-7, KETANSERIN TARTRATERelated Search:

2-(4-BENZYLPIPERIDINO)-1-ETHANAMINE 4-BENZOYLPIPERIDINE HYDROCHLORIDE 4-(4'-Fluorobenzyl)piperidine Butanedioic acid,2,3-dihydroxy- (2R,3R)-, ammonium salt (1:) KETANSERIN TARTRATE BENZOYLUREA 4-(4-Fluorobenzoyl)piperidine N-(2-Aminoethyl)piperidine 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE Benzoyleneurea Ketanserin 4'-Fluoropropiophenone 4-Benzylpiperidine 1-(4-FLUOROPHENYL)-2-METHYLPROPAN-1-ONE 5-Diethylamino-2-pentanone CHEMBRDG-BB 4013122 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE 3,4-DIHYDRO-3-METHYL-2(1H)-QUINAZOLINONE

R 41468

R 41468 TARTRATE SALT

3-(2-(4-(p-fluorobenzoyl)-1-piperidinyl)ethyl)-2,4(1h,3h)-quinazolinedionel

4(1h,3h)-quinazolinedione,3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-(

kjk-945

r-(r*,r*))-2,3-dihydroxybutanedioate(1:1)

3-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H,3H)-dione [R-(R*,R*)]-tartrate

KETANSERIN TARTRATE (R 41468) (SELECTIVE 5-HT2/5-HT1C SEROTONI

Ketanserinetartrate

R 41468 (+)-tartrate salt, 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt

3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]-2,4-(1H,3H)-quinazolinedione tartrate

Ketanserin Tartrat

3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione 2,3-dihydroxysuccinate

R41468 tartrate

3-[2-[4-[(4-fluorophenyl)-oxomethyl]-1-piperidin-1-iumyl]ethyl]-1H-quinazoline-2,4-dione

3-(2-(4-(4-Fluorobenzoyl)

-dione 2,3-dihydroxysuccinate

quinazoline-2,4(1H,3H)

Ketanserin tartrate (R41468 tartrate)

Ketanserin tartrate salt Morpholino

3-[2-(4-FLUOROBENZOYL)-1-PIPERDINYL]-ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE

3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERDINYL]ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE

3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERDINYL]ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE

3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL]-2,4[1H,3H]-QUINAZOLINEDIONE TARTRATE

3-(2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL)-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE SALT

KETANSERIN TARTRATE

KETANSERIN TARTRATE SALT

Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem

Ketanserin Hydrogen Tartrate

2,4(1H,3H)-Quinazolinedione,3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-,(2R,3R)-2,3-dihydroxybutanedioate (1:1)

3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione (2R,3R)-2,3-dihydroxysuccinate

(.+-.)-TARTARIC ACID KETANSERIN HYDRATE

Ketanserin tartrate, 5-HT2 antagonist

Ketanserin tartrate, 10 mM in DMSO

Ketanserin tartrate - Bio-X ?

Ketanserin (+)-tartrate salt >=97%, solid

83846-83-7

C22H22FN3O3C4H6O6

C26H28N3O9F

C4H6O6C22H22FN3O3

C26H28FN3O9

Biochemicals and Reagents

Enzyme Inhibitors

Other

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Type

BioChemical

Serotonin

Cardiovascular APIs

Serotonin receptor