4'-Fluoropropiophenone

Product Name: 4'-Fluoropropiophenone
CAS No.: 456-03-1
Chemical Name: 4'-Fluoropropiophenone
Synonyms: p-fluorophenone;Fluorophenylacetone;P-FLUOROPROPIOPHENONE;4-FLUOROPROPIOPHENONE;LABOTEST-BB LT01148316;4'-fluoropropiophenone;para-Fluoropropiophenone;4-Fluoropropiophenone99%;Propiophenone, 4'-fluoro-;4-Fluoropropiophenone 99%
CBNumber: CB1700848
Molecular Formula: C9H9FO
Formula Weight: 152.17
MOL File: 456-03-1.mol

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4'-Fluoropropiophenone Property

Boiling point:: 100-102 °C (22 mmHg)
Density: 1.096 g/mL at 25 °C (lit.)
refractive index: n20/D 1.5059(lit.)
Flash point:: 170 °F
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
color: Colorless to Light orange to Yellow
Specific Gravity: 1.096
BRN: 1210310
InChI: InChI=1S/C9H9FO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2H2,1H3
InChIKey: QIJNVLLXIIPXQT-UHFFFAOYSA-N
SMILES: C(C1=CC=C(F)C=C1)(=O)CC
CAS DataBase Reference: 456-03-1(CAS DataBase Reference)
NIST Chemistry Reference: 1-Propanone, 1-(4-fluorophenyl)-(456-03-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38
Safety Statements: 26-39-37/39
RIDADR: 2735
WGK Germany: 2
Hazard Note: Irritant
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 128414
Product name: 4′-Fluoropropiophenone
Purity: 98%
Packaging: 5g
Price: $48.3
Updated: 2023/01/07

TCI Chemical

Product number: F0522
Product name: 4'-Fluoropropiophenone
Purity: >97.0%(GC)
Packaging: 5g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: F0522
Product name: 4'-Fluoropropiophenone
Purity: >97.0%(GC)
Packaging: 25g
Price: $26
Updated: 2025/07/31

TRC

Product number: F598745
Product name: 4''-Fluoropropiophenone
Packaging: 500mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0023878
Product name: 4'-FLUOROPROPIOPHENONE
Purity: 95.00%
Packaging: 100G
Price: $2397.32
Updated: 2021/12/16

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4'-Fluoropropiophenone Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid after melting

Uses

4′-Fluoropropiophenone was used in the preparation of 2-(4-fluorophenyl)-3-methylquinoxaline.

Synthesis

5724-03-8

456-03-1

General procedure for the synthesis of 4'-fluoropropiophenone from 1-(4-fluorophenyl)prop-2-en-1-ol: Under nitrogen protection, the ruthenium complex [RuCl2(6-C6H6)(PTA-Me)] (3a) (0.02-0.1 mmol; 0.5-2.5 mol%) and K2CO3 (0.05-0.25 mmol) were added to a solution of 1-(4-fluorophenyl)prop-2-en-1-ol (4a-o, 4 mmol) in tetrahydrofuran (4mL). -fluorophenyl)prop-2-en-1-ol (4a-o, 4 mmol) in a solution of tetrahydrofuran (4 mL). The reaction mixture was placed in a sealed tube and stirred at 75°C for the indicated time (see Table 4 and Scheme 3). The progress of the reaction was monitored by sampling and diluting 10 μL of the sample with dichloromethane (3 mL) every ~1 hr followed by GC analysis. Upon completion of the reaction, the mixture was cooled to room temperature, at which point the ruthenium complex 3a partially precipitated. The solids were removed by filtration and the reaction products were subsequently separated by solvent evaporation. The residue was purified using silica gel column chromatography with EtOAc-hexane (1:10) mixed solvent as eluent. The structure of the resulting carbonyl compounds 5a-o was confirmed by GC/MS analysis of their fragmentation patterns, NMR spectroscopy, and comparison of retention times of commercially pure samples (Sigma-Aldrich or Acros Organics).

References

[1] Tetrahedron, 2008, vol. 64, # 51, p. 11745 - 11750
[2] Journal of Molecular Catalysis A: Chemical, 2013, vol. 366, p. 390 - 399
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 26, p. 3886 - 3895
[4] Green Chemistry, 2010, vol. 12, # 9, p. 1628 - 1633
[5] Organometallics, 2012, vol. 31, # 23, p. 8301 - 8311

4'-Fluoropropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Fluoropropiophenone Suppliers

Americas 1 Belgium 1 China 167 Europe 3 France 1 Germany 3 India 15 Italy 1 Japan 3 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 16 United States 31 Global 246

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View Lastest Price from 4'-Fluoropropiophenone manufacturers

RongNa Biotechnology Co.,Ltd

Product: 4'-Fluoropropiophenone 456-03-1
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 10 ton
Release date: 2025-05-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4'-Fluoropropiophenone 456-03-1
Price: US $99.00-45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-12-19

Shandong Hanjiang Chemical Co., Ltd

Product: 4'-Fluoropropiophenone 456-03-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10T
Release date: 2024-01-19

456-03-1, 4'-FluoropropiophenoneRelated Search:

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P-FLUOROPROPIOPHENONE

ETHYL 4-FLUOROPHENYL KETONE

LABOTEST-BB LT01148316

4-FLUOROPROPIOPHENONE

1-(4-Fluorophenyl)-1-propanone

1-Propanone,1-(4-fluorophenyl)-

para-Fluoropropiophenone

Propiophenone, 4'-fluoro-

4-Fluoropropiophenone99%

4-Fluoropropiophenone 99%

4'-Fluoropropiophenone,97+%

1-(4-fluorophenyl)propan-1-one

Ethyl p-fluorophenyl ketone

4'-difluoroaMilineacetone

The fluorine benzene acetone

4-amino-3-(phenoxymethyl)-1H-1,2,4-triazole-5-thione

4'-Fluoropropiophenone &gt

4'-Fluoropropiophenone USP/EP/BP

High Quality 4'-Fluoropropiophenone

99% purity 4'-Fluoropropiophenone

4'-fluoropropiophenone

p-fluorophenone

4'-Fluoropropiophenone, 98%

4′-Fluoropropiophenone, CAS 456-03-1

Fluorophenylacetone

4-Fluoropropiophenone 99%

456-03-1

Building Blocks

C9

Carbonyl Compounds

Ketones

Organic Building Blocks

C9

Carbonyl Compounds

Ketones

Fluorine Compounds

Aromatic Ketones (substituted)

ketone

Fluorobenzene

Acetophenone Series

Adehydes, Acetals & Ketones

456-03-1