4'-Fluoropropiophenone
- Product Name
- 4'-Fluoropropiophenone
- CAS No.
- 456-03-1
- Chemical Name
- 4'-Fluoropropiophenone
- Synonyms
- p-fluorophenone;Fluorophenylacetone;P-FLUOROPROPIOPHENONE;4-FLUOROPROPIOPHENONE;LABOTEST-BB LT01148316;4'-fluoropropiophenone;para-Fluoropropiophenone;4-Fluoropropiophenone99%;Propiophenone, 4'-fluoro-;4-Fluoropropiophenone 99%
- CBNumber
- CB1700848
- Molecular Formula
- C9H9FO
- Formula Weight
- 152.17
- MOL File
- 456-03-1.mol
4'-Fluoropropiophenone Property
- Boiling point:
- 100-102 °C (22 mmHg)
- Density
- 1.096 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5059(lit.)
- Flash point:
- 170 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- Specific Gravity
- 1.096
- BRN
- 1210310
- InChI
- InChI=1S/C9H9FO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2H2,1H3
- InChIKey
- QIJNVLLXIIPXQT-UHFFFAOYSA-N
- SMILES
- C(C1=CC=C(F)C=C1)(=O)CC
- CAS DataBase Reference
- 456-03-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Propanone, 1-(4-fluorophenyl)-(456-03-1)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-39-37/39
- RIDADR
- 2735
- WGK Germany
- 2
- Hazard Note
- Irritant
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 128414
- Product name
- 4′-Fluoropropiophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $48.3
- Updated
- 2023/01/07
- Product number
- F0522
- Product name
- 4'-Fluoropropiophenone
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $17
- Updated
- 2025/07/31
- Product number
- F0522
- Product name
- 4'-Fluoropropiophenone
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- F598745
- Product name
- 4''-Fluoropropiophenone
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0023878
- Product name
- 4'-FLUOROPROPIOPHENONE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $2397.32
- Updated
- 2021/12/16
4'-Fluoropropiophenone Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid after melting
Uses
4′-Fluoropropiophenone was used in the preparation of 2-(4-fluorophenyl)-3-methylquinoxaline.
Synthesis
5724-03-8
456-03-1
General procedure for the synthesis of 4'-fluoropropiophenone from 1-(4-fluorophenyl)prop-2-en-1-ol: Under nitrogen protection, the ruthenium complex [RuCl2(6-C6H6)(PTA-Me)] (3a) (0.02-0.1 mmol; 0.5-2.5 mol%) and K2CO3 (0.05-0.25 mmol) were added to a solution of 1-(4-fluorophenyl)prop-2-en-1-ol (4a-o, 4 mmol) in tetrahydrofuran (4mL). -fluorophenyl)prop-2-en-1-ol (4a-o, 4 mmol) in a solution of tetrahydrofuran (4 mL). The reaction mixture was placed in a sealed tube and stirred at 75°C for the indicated time (see Table 4 and Scheme 3). The progress of the reaction was monitored by sampling and diluting 10 μL of the sample with dichloromethane (3 mL) every ~1 hr followed by GC analysis. Upon completion of the reaction, the mixture was cooled to room temperature, at which point the ruthenium complex 3a partially precipitated. The solids were removed by filtration and the reaction products were subsequently separated by solvent evaporation. The residue was purified using silica gel column chromatography with EtOAc-hexane (1:10) mixed solvent as eluent. The structure of the resulting carbonyl compounds 5a-o was confirmed by GC/MS analysis of their fragmentation patterns, NMR spectroscopy, and comparison of retention times of commercially pure samples (Sigma-Aldrich or Acros Organics).
References
[1] Tetrahedron, 2008, vol. 64, # 51, p. 11745 - 11750
[2] Journal of Molecular Catalysis A: Chemical, 2013, vol. 366, p. 390 - 399
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 26, p. 3886 - 3895
[4] Green Chemistry, 2010, vol. 12, # 9, p. 1628 - 1633
[5] Organometallics, 2012, vol. 31, # 23, p. 8301 - 8311
4'-Fluoropropiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-Fluoropropiophenone manufacturers
- Product
- 4'-Fluoropropiophenone 456-03-1
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2025-05-04
- Product
- 4'-Fluoropropiophenone 456-03-1
- Price
- US $99.00-45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-12-19
- Product
- 4'-Fluoropropiophenone 456-03-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10T
- Release date
- 2024-01-19