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KETANSERIN TARTRATE

Product Name
KETANSERIN TARTRATE
CAS No.
83846-83-7
Chemical Name
KETANSERIN TARTRATE
Synonyms
kjk-945;R 41468;R41468 tartrate;Ketanserin Tartrat;Ketanserinetartrate;KETANSERIN TARTRATE;R 41468 TARTRATE SALT;quinazoline-2,4(1H,3H);KETANSERIN TARTRATE SALT;3-(2-(4-(4-Fluorobenzoyl)
CBNumber
CB8415888
Molecular Formula
C26H28FN3O9
Formula Weight
545.52
MOL File
83846-83-7.mol
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KETANSERIN TARTRATE Property

Melting point:
183～186℃
storage temp. 
2-8°C
solubility 
ethanol: 3.3mg/mL
form 
solid
color 
white
Water Solubility 
Soluble to 10 mM in water
CAS DataBase Reference
83846-83-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
VA1411195
HazardClass 
6.1
HS Code 
29335990
Toxicity
LD50 oral in rat: 129mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S006
Product name
Ketanserin (+)-tartrate salt
Purity
≥97%, solid
Packaging
10mg
Price
$87.6
Updated
2024/03/01
Sigma-Aldrich
Product number
S006
Product name
Ketanserin (+)-tartrate salt
Purity
≥97%, solid
Packaging
50mg
Price
$279
Updated
2024/03/01
Sigma-Aldrich
Product number
5.06271
Product name
Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem
Packaging
50MG
Price
$126
Updated
2024/03/01
Alfa Aesar
Product number
J62798
Product name
Ketanserin tartrate, 98+%
Packaging
250mg
Price
$390.65
Updated
2024/03/01
Cayman Chemical
Product number
22058
Product name
Ketanserin (tartrate)
Purity
≥98%
Packaging
50mg
Price
$81
Updated
2024/03/01
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KETANSERIN TARTRATE Chemical Properties,Usage,Production

Description

Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.

Uses

coccidiostat

Uses

Selective 5-HT2A serotonin receptor antagonist

Biological Activity

Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes.

Biochem/physiol Actions

Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.

storage

Room temperature

KETANSERIN TARTRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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KETANSERIN TARTRATE Suppliers

China 111 Europe 1 Germany 2 India 1 Switzerland 2 United Kingdom 8 United States 16 Global 141
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View Lastest Price from KETANSERIN TARTRATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ketanserin tartrate 83846-83-7
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
99%min
Supply Ability
10kg
Release date
2021-08-14
Henan Bao Enluo International TradeCo.，LTD
Product
KETANSERIN TARTRATE 83846-83-7
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-06-19
Hebei Lingding Biotechnology Co., Ltd.
Product
Ketanserin Tartrate 83846-83-7
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-06-08

83846-83-7, KETANSERIN TARTRATERelated Search:

2-(4-BENZYLPIPERIDINO)-1-ETHANAMINE 4-BENZOYLPIPERIDINE HYDROCHLORIDE 4-(4'-Fluorobenzyl)piperidine Butanedioic acid,2,3-dihydroxy- (2R,3R)-, ammonium salt (1:) KETANSERIN TARTRATE BENZOYLUREA 4-(4-Fluorobenzoyl)piperidine N-(2-Aminoethyl)piperidine 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE Benzoyleneurea Ketanserin 4'-Fluoropropiophenone 4-Benzylpiperidine 1-(4-FLUOROPHENYL)-2-METHYLPROPAN-1-ONE 5-Diethylamino-2-pentanone CHEMBRDG-BB 4013122 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE 3,4-DIHYDRO-3-METHYL-2(1H)-QUINAZOLINONE

  • R 41468
  • R 41468 TARTRATE SALT
  • 3-(2-(4-(p-fluorobenzoyl)-1-piperidinyl)ethyl)-2,4(1h,3h)-quinazolinedionel
  • 4(1h,3h)-quinazolinedione,3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-(
  • kjk-945
  • r-(r*,r*))-2,3-dihydroxybutanedioate(1:1)
  • 3-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H,3H)-dione [R-(R*,R*)]-tartrate
  • KETANSERIN TARTRATE (R 41468) (SELECTIVE 5-HT2/5-HT1C SEROTONI
  • Ketanserinetartrate
  • R 41468 (+)-tartrate salt, 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt
  • 3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]-2,4-(1H,3H)-quinazolinedione tartrate
  • Ketanserin Tartrat
  • 3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione 2,3-dihydroxysuccinate
  • R41468 tartrate
  • 3-[2-[4-[(4-fluorophenyl)-oxomethyl]-1-piperidin-1-iumyl]ethyl]-1H-quinazoline-2,4-dione
  • 3-(2-(4-(4-Fluorobenzoyl)
  • -dione 2,3-dihydroxysuccinate
  • quinazoline-2,4(1H,3H)
  • Ketanserin tartrate (R41468 tartrate)
  • Ketanserin tartrate salt Morpholino
  • 3-[2-(4-FLUOROBENZOYL)-1-PIPERDINYL]-ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE
  • 3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERDINYL]ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE
  • 3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERDINYL]ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE
  • 3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL]-2,4[1H,3H]-QUINAZOLINEDIONE TARTRATE
  • 3-(2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL)-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE SALT
  • KETANSERIN TARTRATE
  • KETANSERIN TARTRATE SALT
  • Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem
  • Ketanserin Hydrogen Tartrate
  • 2,4(1H,3H)-Quinazolinedione,3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-,(2R,3R)-2,3-dihydroxybutanedioate (1:1)
  • 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione (2R,3R)-2,3-dihydroxysuccinate
  • 83846-83-7
  • C22H22FN3O3C4H6O6
  • C26H28N3O9F
  • C4H6O6C22H22FN3O3
  • C26H28FN3O9
  • Biochemicals and Reagents
  • Enzyme Inhibitors
  • Other
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • BioChemical
  • Serotonin
  • Cardiovascular APIs
  • Serotonin receptor