BENZETIMIDE

Product Name: BENZETIMIDE
CAS No.: 21888-98-2
Chemical Name: BENZETIMIDE
Synonyms: R 16470;BENZETIMIDE;Dexbenzetimide;DEXETIMIDE HCL;(+)-Benzetimide;RSYYBENZETIMIDE;Dextrobenzetimide;(S)-(+)-Dexetimide;BENZETIMIDE USP/EP/BP;(+)-DEXETIMIDE HYDROCHLORIDE
CBNumber: CB6343451
Molecular Formula: C23H26N2O2
Formula Weight: 362.46
MOL File: 21888-98-2.mol

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BENZETIMIDE Property

Melting point:: 181-183°
alpha: D20 +125° (chloroform)
Boiling point:: 543.9±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 100 mg/mL (275.89 mM)
pka: 11.20±0.40(Predicted)

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0026226
Product name: Dexetimide
Purity: 99.20%
Packaging: 10mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0026226
Product name: Dexetimide
Purity: 99.20%
Packaging: 50mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006654
Product name: DEXETIMIDE
Purity: 95.00%
Packaging: 5MG
Price: $504.38
Updated: 2021/12/16

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BENZETIMIDE Chemical Properties,Usage,Production

Originator

Tremblex,Brocades,Italy,1981

Uses

Anticholinergic.

Definition

ChEBI: Dexetimide is a member of piperidines.

Manufacturing Process

400 parts glacial acetic acid are cooled to 10°C to 20°C. Then there are added first dropwise 300 parts concentrated sulfuric acid followed by portionwise addition of 50 parts dl-1-benzyl-4-(1,3-dicyano-1-phenylpropyl)-piperidine hydrochloride at the same temperature. After the addition is complete, the whole is heated to 125°C in the course of 15 to 20 minutes. This temperature is then maintained for 10 minutes. After cooling, the reaction mixture is poured into ice, alkalized with NH4OH at a temperature < 20°C and extracted with chloroform. The chloroform layer is first washed twice with a K2CO3 5% solution, and then washed twice with water, dried over MgSO4, filtered and evaporated. The residue is dissolved in a mixture of 320 parts acetone and 600 parts diisopropylether, filtered and HCl gas is introduced into the filtrate. The solid hydrochloride is filtered off and dried, to yield 43 parts less pure lbenzyl-4-(2.6-dioxo-3-phenyl-3-piperidyl)-piperidine hydrochloride, melting point 283°C to 294°C.
A sample of 4 parts is recrystallized from a boiling mixture of 80 parts isopropanol, 40 parts methanol and 500 parts water. The whole is filtered and after cooling the filtrate overnight at -20°C, 1-benzyl-4-(2,6-dioxo-3phenyl-3- piperidyl)-piperidine hydrochloride is obtained, melting point 299°C to 301.5°C, as a white amorphous powder.
The dextro-isomer may be separated via the dextro-camphorsulfonate of the base.

Therapeutic Function

Anticholinergic (ophthalmic)

BENZETIMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZETIMIDE Suppliers

China 17 Europe 2 South Korea 1 Switzerland 3 United Kingdom 1 United States 10 Global 34

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9767
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4880
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 29220
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

Jinan Ruisi Pharmaceutical Technology Co., LTD

Tel: 0531-69900633 18340090523
Email: changyuan20@163.com
Country: China
ProdList: 1717
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

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View Lastest Price from BENZETIMIDE manufacturers

Dideu Industries Group Limited

Product: BENZETIMIDE 21888-98-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-27

21888-98-2, BENZETIMIDERelated Search:

(1-Methyl-piperidin-4-yl)-acetaldehyde 7-DIETHYLAMINOHEPTYLAMINE BENZETIMIDE HCL,BENZETIMIDE HYDROCHLORIDE 1,5-DIAMINO-2-METHYLPENTANE 4-Benzylpiperidine DL-Glutethimide 2-PHENYLBUTYRAMIDE 2,2-DI-N-PROPYLACETAMIDE 3,3-DIMETHYLPIPERIDINE 4-BUTYLPIPERIDINE 2-Piperidone 4-N-PROPYLPIPERIDINE BENZETIMIDE alpha-Methylhydratropamide N-(2-PIPERIDIN-4-YL-ETHYL)-ACETAMIDE (R)-2-PHENYLPROPYLAMIDE 4-tert-butylpiperidine 3-methyl-3-phenylpiperidine

[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-

Dexbenzetimide

Dextrobenzetimide

DEXETIMIDE HCL

(+)-DEXETIMIDE HYDROCHLORIDE

BENZETIMIDE

3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE HYDROCHLORIDE

R 16470

(S)-(+)-3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE, HCL

S(+)-DEXETIMIDE HYDROCHLORIDE

S(+)-DEXETIMIDE HYDROCHLORIDE (R16470) H IGH AFFINITY MUSCARI

(3S)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione

(S)-(+)-Dexetimide

[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)-

BENZETIMIDE USP/EP/BP

(+)-Benzetimide

RSYYBENZETIMIDE

21888-98-2

21888-96-9