BENZETIMIDE

Product Name: BENZETIMIDE
CAS No.: 21888-98-2
Chemical Name: BENZETIMIDE
Synonyms: R 16470;BENZETIMIDE;Dexbenzetimide;DEXETIMIDE HCL;(+)-Benzetimide;RSYYBENZETIMIDE;Dextrobenzetimide;(S)-(+)-Dexetimide;BENZETIMIDE USP/EP/BP;(+)-DEXETIMIDE HYDROCHLORIDE
CBNumber: CB6343451
Molecular Formula: C23H26N2O2
Formula Weight: 362.46
MOL File: 21888-98-2.mol

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BENZETIMIDE Property

Melting point:: 181-183°
alpha: D20 +125° (chloroform)
Boiling point:: 543.9±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 100 mg/mL (275.89 mM)
pka: 11.20±0.40(Predicted)
form: Solid
color: White to off-white

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0026226
Product name: Dexetimide
Purity: 99.20%
Packaging: 10mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0026226
Product name: Dexetimide
Purity: 99.20%
Packaging: 50mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006654
Product name: DEXETIMIDE
Purity: 95.00%
Packaging: 5MG
Price: $504.38
Updated: 2021/12/16

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BENZETIMIDE Chemical Properties,Usage,Production

Originator

Tremblex,Brocades,Italy,1981

Uses

Anticholinergic.

Definition

ChEBI: Dexetimide is a member of piperidines.

Manufacturing Process

400 parts glacial acetic acid are cooled to 10°C to 20°C. Then there are added first dropwise 300 parts concentrated sulfuric acid followed by portionwise addition of 50 parts dl-1-benzyl-4-(1,3-dicyano-1-phenylpropyl)-piperidine hydrochloride at the same temperature. After the addition is complete, the whole is heated to 125°C in the course of 15 to 20 minutes. This temperature is then maintained for 10 minutes. After cooling, the reaction mixture is poured into ice, alkalized with NH4OH at a temperature < 20°C and extracted with chloroform. The chloroform layer is first washed twice with a K2CO3 5% solution, and then washed twice with water, dried over MgSO4, filtered and evaporated. The residue is dissolved in a mixture of 320 parts acetone and 600 parts diisopropylether, filtered and HCl gas is introduced into the filtrate. The solid hydrochloride is filtered off and dried, to yield 43 parts less pure lbenzyl-4-(2.6-dioxo-3-phenyl-3-piperidyl)-piperidine hydrochloride, melting point 283°C to 294°C.
A sample of 4 parts is recrystallized from a boiling mixture of 80 parts isopropanol, 40 parts methanol and 500 parts water. The whole is filtered and after cooling the filtrate overnight at -20°C, 1-benzyl-4-(2,6-dioxo-3phenyl-3- piperidyl)-piperidine hydrochloride is obtained, melting point 299°C to 301.5°C, as a white amorphous powder.
The dextro-isomer may be separated via the dextro-camphorsulfonate of the base.

Therapeutic Function

Anticholinergic (ophthalmic)

BENZETIMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZETIMIDE Suppliers

China 19 Europe 2 South Korea 1 Switzerland 3 United Kingdom 1 United States 11 Global 37

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30239
Advantage: 58

Jinan Ruisi Pharmaceutical Technology Co., LTD

Tel: 0531-69900633 18340090523
Email: changyuan20@163.com
Country: China
ProdList: 2649
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

21888-98-2, BENZETIMIDERelated Search:

(1-Methyl-piperidin-4-yl)-acetaldehyde 7-DIETHYLAMINOHEPTYLAMINE BENZETIMIDE HCL,BENZETIMIDE HYDROCHLORIDE 1,5-DIAMINO-2-METHYLPENTANE 4-Benzylpiperidine DL-Glutethimide 2-PHENYLBUTYRAMIDE 2,2-DI-N-PROPYLACETAMIDE 3,3-DIMETHYLPIPERIDINE 4-BUTYLPIPERIDINE 2-Piperidone 4-N-PROPYLPIPERIDINE BENZETIMIDE alpha-Methylhydratropamide N-(2-PIPERIDIN-4-YL-ETHYL)-ACETAMIDE (R)-2-PHENYLPROPYLAMIDE 4-tert-butylpiperidine 3-methyl-3-phenylpiperidine

[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-

Dexbenzetimide

Dextrobenzetimide

DEXETIMIDE HCL

(+)-DEXETIMIDE HYDROCHLORIDE

BENZETIMIDE

3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE HYDROCHLORIDE

R 16470

(S)-(+)-3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE, HCL

S(+)-DEXETIMIDE HYDROCHLORIDE

S(+)-DEXETIMIDE HYDROCHLORIDE (R16470) H IGH AFFINITY MUSCARI

(3S)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione

(S)-(+)-Dexetimide

[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)-

BENZETIMIDE USP/EP/BP

(+)-Benzetimide

RSYYBENZETIMIDE

21888-98-2

21888-96-9