2-Piperidone
- Product Name
- 2-Piperidone
- CAS No.
- 675-20-7
- Chemical Name
- 2-Piperidone
- Synonyms
- piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;ALPHA-PIPERIDONE;Piperidon;Piperidone-2
- CBNumber
- CB3680771
- Molecular Formula
- C5H9NO
- Formula Weight
- 99.13
- MOL File
- 675-20-7.mol
2-Piperidone Property
- Melting point:
- 38-40 °C (lit.)
- Boiling point:
- 256 °C (lit.) 81-82 °C/0.1 mmHg (lit.)
- Density
- 1.073
- refractive index
- 1.4431 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Low Melting Crystalline Mass
- color
- White to yellow to brown
- PH
- 4.8 (200g/l, H2O, 20℃)
- explosive limit
- 1.5-8.7%(V)
- Water Solubility
- 291 g/L (25 ºC)
- Sensitive
- Hygroscopic
- BRN
- 106434
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- InChIKey
- XUWHAWMETYGRKB-UHFFFAOYSA-N
- CAS DataBase Reference
- 675-20-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Piperidinone(675-20-7)
- EPA Substance Registry System
- 2-Piperidone (675-20-7)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37-36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- RTECS
- TO0110000
- F
- 3-10
- TSCA
- Yes
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- V209
- Product name
- δ-Valerolactam
- Purity
- 98%
- Packaging
- 25g
- Price
- $80.7
- Updated
- 2024/03/01
- Product number
- V209
- Product name
- δ-Valerolactam
- Purity
- 98%
- Packaging
- 100g
- Price
- $212
- Updated
- 2024/03/01
- Product number
- P0455
- Product name
- 2-Piperidone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- P0455
- Product name
- 2-Piperidone
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $184
- Updated
- 2024/03/01
- Product number
- A12271
- Product name
- delta-Valerolactam, 98%
- Packaging
- 25g
- Price
- $60.65
- Updated
- 2024/03/01
2-Piperidone Chemical Properties,Usage,Production
Chemical Properties
white to yellowish low melting crystalline mass
Uses
δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.
Definition
ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.
Preparation
2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 7629, 1980 DOI: 10.1021/ja00546a001
Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8
The Journal of Organic Chemistry, 21, p. 965, 1956 DOI: 10.1021/jo01115a010
Purification Methods
Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]
2-Piperidone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Piperidone manufacturers
- Product
- 2-Piperidone 675-20-7
- Price
- US $23.00-18.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000tons
- Release date
- 2024-04-07
- Product
- 2-Piperidone 675-20-7
- Price
- US $65.00-45.00/kg
- Min. Order
- 500kg
- Purity
- 99.9
- Supply Ability
- 200tons
- Release date
- 2024-03-08
- Product
- 2-Piperidone 675-20-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 300MT/month
- Release date
- 2022-11-24