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2-Piperidone

Product Name
2-Piperidone
CAS No.
675-20-7
Chemical Name
2-Piperidone
Synonyms
piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;ALPHA-PIPERIDONE;Piperidon;Piperidone-2
CBNumber
CB3680771
Molecular Formula
C5H9NO
Formula Weight
99.13
MOL File
675-20-7.mol
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2-Piperidone Property

Melting point:
38-40 °C (lit.)
Boiling point:
256 °C (lit.) 81-82 °C/0.1 mmHg (lit.)
Density 
1.073
refractive index 
1.4431 (estimate)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Low Melting Crystalline Mass
color 
White to yellow to brown
PH
4.8 (200g/l, H2O, 20℃)
explosive limit
1.5-8.7%(V)
Water Solubility 
291 g/L (25 ºC)
Sensitive 
Hygroscopic
BRN 
106434
Stability:
Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey
XUWHAWMETYGRKB-UHFFFAOYSA-N
CAS DataBase Reference
675-20-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Piperidinone(675-20-7)
EPA Substance Registry System
2-Piperidone (675-20-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37-36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
RTECS 
TO0110000
3-10
TSCA 
Yes
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V209
Product name
δ-Valerolactam
Purity
98%
Packaging
25g
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
V209
Product name
δ-Valerolactam
Purity
98%
Packaging
100g
Price
$212
Updated
2024/03/01
TCI Chemical
Product number
P0455
Product name
2-Piperidone
Purity
>98.0%(GC)
Packaging
25g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
P0455
Product name
2-Piperidone
Purity
>98.0%(GC)
Packaging
100g
Price
$184
Updated
2024/03/01
Alfa Aesar
Product number
A12271
Product name
delta-Valerolactam, 98%
Packaging
25g
Price
$60.65
Updated
2024/03/01
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2-Piperidone Chemical Properties,Usage,Production

Chemical Properties

white to yellowish low melting crystalline mass

Uses

δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.

Definition

ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.

Preparation

2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 7629, 1980 DOI: 10.1021/ja00546a001
Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8
The Journal of Organic Chemistry, 21, p. 965, 1956 DOI: 10.1021/jo01115a010

Purification Methods

Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]

2-Piperidone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Piperidone Suppliers

TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from 2-Piperidone manufacturers

Shandong Juchuang Chemical Co., LTD
Product
2-Piperidone 675-20-7
Price
US $65.00-45.00/kg
Min. Order
500kg
Purity
99.9
Supply Ability
200tons
Release date
2024-03-08
Hebei Duling International Trade Co. LTD
Product
2-Piperidone 675-20-7
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
300MT/month
Release date
2022-11-24
Shaanxi Dideu Medichem Co. Ltd
Product
2-Piperidone 675-20-7
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31

675-20-7, 2-PiperidoneRelated Search:


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