ChemicalBook > CAS DataBase List > 2-Piperidone

2-Piperidone

Product Name
2-Piperidone
CAS No.
675-20-7
Chemical Name
2-Piperidone
Synonyms
piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;ALPHA-PIPERIDONE;Piperidon;Piperidone-2
CBNumber
CB3680771
Molecular Formula
C5H9NO
Formula Weight
99.13
MOL File
675-20-7.mol
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2-Piperidone Property

Melting point:
38-40 °C (lit.)
Boiling point:
256 °C (lit.) 81-82 °C/0.1 mmHg (lit.)
Density 
1.073
refractive index 
1.4431 (estimate)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Low Melting Crystalline Mass
color 
White to yellow to brown
PH
4.8 (200g/l, H2O, 20℃)
explosive limit
1.5-8.7%(V)
Water Solubility 
291 g/L (25 ºC)
Sensitive 
Hygroscopic
BRN 
106434
Stability:
Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey
XUWHAWMETYGRKB-UHFFFAOYSA-N
CAS DataBase Reference
675-20-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Piperidinone(675-20-7)
EPA Substance Registry System
2-Piperidone (675-20-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37-36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
RTECS 
TO0110000
F 
3-10
TSCA 
Yes
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V209
Product name
δ-Valerolactam
Purity
98%
Packaging
25g
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
V209
Product name
δ-Valerolactam
Purity
98%
Packaging
100g
Price
$212
Updated
2024/03/01
TCI Chemical
Product number
P0455
Product name
2-Piperidone
Purity
>98.0%(GC)
Packaging
25g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
P0455
Product name
2-Piperidone
Purity
>98.0%(GC)
Packaging
100g
Price
$184
Updated
2024/03/01
Alfa Aesar
Product number
A12271
Product name
delta-Valerolactam, 98%
Packaging
25g
Price
$60.65
Updated
2024/03/01
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2-Piperidone Chemical Properties,Usage,Production

Chemical Properties

white to yellowish low melting crystalline mass

Uses

δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.

Definition

ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.

Preparation

2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 7629, 1980 DOI: 10.1021/ja00546a001
Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8
The Journal of Organic Chemistry, 21, p. 965, 1956 DOI: 10.1021/jo01115a010

Purification Methods

Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]

2-Piperidone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Piperidone Suppliers

Americas 1 Belgium 2 China 293 Europe 2 France 2 Germany 10 India 14 Japan 7 Slovakia 1 Switzerland 4 Ukraine 1 United Kingdom 11 United States 40 USA 1 Global 389
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View Lastest Price from 2-Piperidone manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
2-Piperidone 675-20-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98
Supply Ability
1000
Release date
2024-12-25
Shaanxi Dideu Medichem Co. Ltd
Product
2-Piperidone 675-20-7
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31
Wuhan Boyuan Import & Export Co., LTD
Product
2-Piperidone 675-20-7
Price
US $23.00-18.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000tons
Release date
2024-04-07

675-20-7, 2-PiperidoneRelated Search:

N-Methyl-2-pyrrolidone Cyclohexanone Laurocapram Cyclopentanone Buspirone TRIAMYLAMINE Propyzamide Amylamine Diltiazem hydrochloride 1,5-Diaminopentane 2',6'-Pipecoloxylidide 3,5-Diiodo-L-tyrosine dihydrate 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 3,4-Dimethoxy-L-phenylalanine Piperidine Chlorophacinone 3-CARBETHOXY-2-PIPERIDONE 3,3-Tetramethyleneglutarimide

  • 2-Piperidinone for synthesis
  • 2-KETOPIPERIDINE
  • 2-AZACYCLOHEXANONE
  • 5-pentanelactam
  • 5-Pentanolactam
  • Pentanoic acid, 5-amino-, lactam
  • Piperidon
  • Piperidone-2
  • valerolactim
  • delta-Valerolactame
  • delta-Valerolactam,97%
  • i-valerolactam
  • 3,4,5,6-Tetrahydropyridine-2-ol
  • 5-Aminovaleric acid lactam
  • ^d-Valerolactam, 98+%
  • delta-Valerolactam,99%
  • δ-Valerolactam, 98+%
  • Left Bupivacaine Impurity 10
  • VALEROLACTAM
  • piperidin-2-one
  • D-VALEROLACTAM
  • DELTA-VALEROLACTAM
  • ALPHA-PIPERIDONE
  • 6-VALEROLACTAM
  • 2-PIPERIDONE
  • 2-PIPERIDINONE
  • 2-Piperidone ,98.5%
  • 2-Oxo-piperidine
  • delta-Valerolactam, 2-Azacyclohexan-1-one
  • Piperidin-5-one
  • Piperidin-6-one
  • Piperidin-7-one
  • delta-ValerolactaM, 99% 100GR
  • delta-ValerolactaM, 99% 25GR
  • delta-ValerolactaM, 99% 5GR
  • 2-Azacyclohexanone delta-Valerolactam
  • 2-Piperidone Synonyms Piperidin-2-one
  • δ-Valerolactam, >=99%
  • delta-Valerolactam, 98+%
  • delta-ValerolactaM 98%
  • 2-Piperidone, 97+%
  • 3-CHLORO-2-(HYDROX...
  • 2-Piperidone&gt
  • Bupivacaine Impurity 26
  • 2-PIPERIDONE 675-20-7
  • RSSYY(Perospirone Hydrochloride Hydrate)-14
  • RSSYY(Perospirone Hydrochloride Hydrate)-11
  • 2-Piperidone (8CI)
  • Piperidone impurity 2（Bupivacaine Impurity7）
  • Valarolactam
  • Meso-2,4-Dichloropentane
  • 2-Piperidone, Valerolactam, 2-Azacyclohexanone, 2-Ketopiperidine, 2-Piperidinone, 2-Piperidone, 6-Valerolactam, Alpha-Piperidone, Delta-Valerolactam, D-Valerolactam, Piperidin-2-one, Valerolactam, 5-Pentanelactam, 5-Pentanolactam, Pentanoic acid, 5-amino-, lactam, Piperidon, Piperidone-2, valerolactim, delta-Valerolactame, delta-Valerolactam, i-valerolactam
  • 675-20-7
  • 675-20-8
  • 675-20-9
  • Lactams
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