3,5-Diiodo-L-tyrosine dihydrate

Product Name: 3,5-Diiodo-L-tyrosine dihydrate
CAS No.: 300-39-0
Chemical Name: 3,5-Diiodo-L-tyrosine dihydrate
Synonyms: (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID
CBNumber: CB5490149
Molecular Formula: C9H9I2NO3
Formula Weight: 432.98
MOL File: 300-39-0.mol

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3,5-Diiodo-L-tyrosine dihydrate Property

Melting point:: 200 °C (dec.)(lit.)
alpha: -20.7 º (c=2.5, 0.1N NaOH/H2O)
Boiling point:: 546.5°C (rough estimate)
Density: 2.405±0.06 g/cm3(Predicted)
refractive index: 1.2 ° (C=5, 1mol/L HCl)
storage temp.: 2-8°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly)
pka: 2.12(at 25℃)
form: crystalline
color: white
Water Solubility: slightly soluble
Sensitive: Light Sensitive
CAS DataBase Reference: 300-39-0(CAS DataBase Reference)
NIST Chemistry Reference: 3,5-Diiodo-l-tyrosine(300-39-0)
EPA Substance Registry System: L-Tyrosine, 3,5-diiodo- (300-39-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36/37-24/25
RIDADR: 2811
WGK Germany: 3
F: 8
TSCA: Yes
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H65420
Product name: 3,5-Diiodo-L-tyrosine, 95%
Packaging: 25g
Price: $66.5
Updated: 2021/12/16

Alfa Aesar

Product number: H65420
Product name: 3,5-Diiodo-L-tyrosine, 95%
Packaging: 100g
Price: $210
Updated: 2021/12/16

TRC

Product number: D466055
Product name: 3,5-Diiodo-L-tyrosine
Packaging: 5g
Price: $85
Updated: 2021/12/16

TRC

Product number: D466055
Product name: 3,5-Diiodo-L-tyrosine
Packaging: 25g
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD46930
Product name: 3,5-Diiodo-L-tyrosine
Packaging: 500g
Price: $175
Updated: 2021/12/16

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3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Usage,Production

Description

Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.

Chemical Properties

white to beige powder

Uses

It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.

Uses

3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.

Uses

3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.

Definition

ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.

Synthesis

Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.

Purification Methods

It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]

3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

L-Thyroxine

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3,5-Diiodo-L-tyrosine dihydrate Suppliers

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View Lastest Price from 3,5-Diiodo-L-tyrosine dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,5-Diiodo-L-tyrosine dihydrate 300-39-0
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98%min
Supply Ability: 100kgs
Release date: 2021-08-23

Hebei Weibang Biotechnology Co., Ltd

Product: 3,5-Diiodo-L-tyrosine dihydrate 300-39-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Hebei Yanxi Chemical Co., Ltd.

Product: 3,5-Diiodo-L-tyrosine dihydrate 300-39-0
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-20

300-39-0, 3,5-Diiodo-L-tyrosine dihydrateRelated Search:

Prostratin, PKC activator H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH L-Alanine Boc-D-Tyr-OH L-Tyrosine 2',6'-Pipecoloxylidide 2-Piperidone 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 3,4-Dimethoxy-L-phenylalanine L-Thyroxine FMOC-3,5-DIIODO-L-TYROSINE N-Acetyl-3,5-Diiodo-L-tyrosine dihydrate 3 5-DIIODO-L-TYROSINE DIHYDRATE 98%,3 5-DIIODO-L-TYROSINE DIHYDRATE 98 Levothyroxine sodium Sodium levothyroxine Liothyronine sodium 3,3',5-Triiodo-L-thyronine 3,5-Diiodo-L-thyronine

3,5-Diiodo-L-tyrosine dihydrate, BR

Liothyronine EP Impurity B

3,5-Diiodo-4-hydroxy-β-phenylalanine

3,5-diiodo-l-tyrosin

3,5-Diiodotyrocine

3,5-Iodo-L-tyrosine

3,5-L-Diiodotyrosine

4-Hydroxy-3,5-diiodophenylalanine

diiodotyrosine

L-3,5-DiioDOTyrosine

Tryosine, 3,5-diiodo-

Tyrosine, 3,5-diiodo-, L-

L-Diiodotyrosine

3,5-Diiodo-L-tyrosine dihydrate,99%

5-Diiodo-L-tyrosinedehydrate

(S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid

L-4-hydroxy-3,5-diiodo-phenylalanine

DI-IODO-L-TYROSINE(P)

3,5-Diiodo-L-Tyr-OH

3,7-DibroMo-L-Tyrosine

3,5-Diiodo-L-Tyr-OH, 98.5%

(2S)-2-amino-3-(4-hydroxy-3,5-diiodo-phenyl)propanoic acid

H-Tyr(3,5-Di-I)-OH

3,5-Diiodo-L-tyrosinedehydrate

3,5-DIIODO-4-HYDROXY-BETA-PHENYLALANINE

3,5-DIIODINE-L-TYROSINE

3,5-DIIODO-BETA(4-HYDROXYPHENYL)ALANINE

3,5-DIIODO-TYROSINE

4-HYDROXY-3,5-DIIODOPHENYLALANINE, 2-AMINO-3-(4-HYDROXY-3,5-DIIODOPHENYL)PROPIONIC ACID

AGONTAN

L-TYROSINE, 3,5-DIIODO-

DITYRIN

H-TYR(3,5-I2)-OH

IODOGORGOIC ACID

H-3,5-DIIODO-TYR-OH

H-L-TYR(3,5-I2)-OH

3,5-Diiodo-beta-(p-hydroxyphenyl)alanine dihydrate

H-L-Tyr(3,5-I2)-OH*2H2O

3,5-Diiodo-L

-tyrosine dihydrate

Levofolinate Impurity 2 (Liothyronine EP Impurity B)

3,5-Diiodo-L-tyrosine dihydrate USP/EP/BP

Liothyronine sodium EP Impurity B

TIANFU CHEM--3,5-Diiodo-L-tyrosine dihydrate

Liothyronine Impurity 2 (Liothyronine EP Impurity B)

DIIODO-L-TYROSINE

3,5-Diiodo-L-tyrosine (Liothyronine Impurity)

300-39-0

C9H9I2NO3x2H2O

C9H9I2NO3

C9H912NO3

C9H9I2NO32H2O

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Modified Amino Acids

A - H

Peptide Synthesis