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Liothyronine sodium

Product Name
Liothyronine sodium
CAS No.
55-06-1
Chemical Name
Liothyronine sodium
Synonyms
Ibiot;Cyomel;T3, NA;Cytobin;Cynomel;Cytomine;Triostat;Sodium T3;Tertroxin;T3 Sodium
CBNumber
CB3195390
Molecular Formula
C15H11I3NNaO4
Formula Weight
672.96
MOL File
55-06-1.mol
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Liothyronine sodium Property

Melting point:
205 °C (dec.)(lit.)
alpha 
20 º (c=2,alcohol/1.2N HCl)
RTECS 
YP2836500
storage temp. 
2-8°C
solubility 
4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
form 
powder
color 
White to Pale Brown
Water Solubility 
Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.
Sensitive 
Light Sensitive
Merck 
5510
BRN 
8179867
CAS DataBase Reference
55-06-1(CAS DataBase Reference)
EPA Substance Registry System
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (55-06-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
22-24/25-36
WGK Germany 
3
3-8-10
HS Code 
29379000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T2752
Product name
3,3′,5-Triiodo-L-thyronine sodium salt
Purity
≥95% (HPLC)
Packaging
100mg
Price
$52.5
Updated
2020/08/18
Sigma-Aldrich
Product number
T2752
Product name
3,3′,5-Triiodo-L-thyronine sodium salt
Purity
≥95% (HPLC)
Packaging
250mg
Price
$146
Updated
2020/08/18
Alfa Aesar
Product number
J63312
Product name
3,3',5'-Triiodo-L-thyronine sodium salt
Packaging
500mg
Price
$115
Updated
2020/06/24
Alfa Aesar
Product number
J63312
Product name
3,3',5'-Triiodo-L-thyronine sodium salt
Packaging
1g
Price
$206
Updated
2020/06/24
Cayman Chemical
Product number
16028
Product name
3,3',5-Triiodo-L-thyronine (sodium salt)
Purity
≥98%
Packaging
1g
Price
$175
Updated
2020/06/24
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Liothyronine sodium Chemical Properties,Usage,Production

Chemical Properties

white to beige powder

Originator

Cytomel,SKF,US,1956

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Uses

cytochrome P450 inhibitor, Ca antagonist, anesthetic (local)

Definition

ChEBI: The sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma.

Indications

Liothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3 alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.

Manufacturing Process

The 3,5-diiodo compound used as a starting material is a known material and may be prepared by the method in British Patents 643,089 and 671,070 and in the Journal of the Chemical Society, London, 1949, page 3424.
Synthesis: L-diiodo thyronine (1.05 g) is dissolved in ammonia (specific gravity 0.880) (40 ml) and methanol (40 ml) and iodinated slowly with shaking with N-iodine in KI solution at room temperature. After iodination,most of the ammonia and methanol are removed by evaporation under diminished pressure, water is added to the original volume, the solution is heated to 60°C and brought to pH 4 with hydrochloric acid. A crystalline precipitate is obtained which after cooling to room temperature is collected and washed with water. At this stage, the crude triiodo thyronine is contaminated with thyroxine and a little unchanged diiodo thyronine.
Purification: The crude precipitate is dissolved in boiling 2N HCl (300 ml) and filtered from the relatively insoluble thyroxine hydrochloride. The hot filtrate is brought to pH 4 with 5N NaOH and triiodo thyronine again separates; after chilling at 0° to 4°C it is collected, washed with water and dried. The yield of triiodo thyronine is 70 to 75% of the theoretical. This triiodo thyronine still contains some thyroxine (about 10%).
The final purification consists of chromatographic separation of thyroxine and triiodo thyronine on a kieselguhr column using 20% chloroform in n-butanol equilibrated with 0.5N NaOH as the developing solvent. 80 to 100 mg triiodo thyronine is purified during each run on a 50 g kieselguhr column. Pure Ltriiodo thyronine has MP 236° to 237°C (dec.) and [α]D29.5° = +21.5 in a 4.75% solution in a mixture of 1 part of N HCl and 2 parts of ethanol. Liothyronine is commonly used as the sodium salt.

brand name

Thyroid hormone Cytomel (King); Triostat (Jones).

Therapeutic Function

Thyroid hormone

Veterinary Drugs and Treatments

Because of its shorter duration of action, liothyronine is generally not considered the drug of first choice in treating hypothyroidism. Infrequently, animals not responding to levothyroxine may respond to liothyronine.

Liothyronine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Liothyronine sodium Suppliers

Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
+86-512-68780025
Fax
+86-512-68780026
Email
sales@ryanchem.com
Country
China
ProdList
147
Advantage
62
Suzhou Pharmaceutical Technology co.,ltd
Fax
051282177481
Email
lsenfy@126.com
Country
China
ProdList
56
Advantage
61
Shifang ShengYuan Technology Co., Ltd.
Tel
13402890778,
Email
1120021438@qq.com
Country
China
ProdList
174
Advantage
56
Shanghai Mokay Pharmaceutical Technology Co., Ltd.
Tel
021-60257269 18601606476
Fax
+86-21-60253672
Email
yl@mkpharma.cn
Country
China
ProdList
206
Advantage
58
Shanghai Mokai Pharmaceutical Technology Co., Ltd.
Tel
021-60951261;021-60951261
Email
nancy@mkpharma.cn;dhn@mkpharma.cn
Country
China
ProdList
228
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40268
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15880
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30163
Advantage
84
BeiJing Hwrk Chemicals Limted
Tel
0757-86311057-
Fax
0757-86311057
Email
kennyrong@hwrkchemical.com
Country
China
ProdList
18708
Advantage
55
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View Lastest Price from Liothyronine sodium manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Liothyronine sodium
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-12-28
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Liothyronine sodium 55-06-1
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-11
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
T3 Sodium 55-06-1
Price
US $1.00/g
Min. Order
10g
Purity
98.5-99.9%HPLC,USP36
Supply Ability
9999KGs
Release date
2020-10-15

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