Diclofenac sodium
Uses Mechanisms of action Clinical Application- Product Name
- Diclofenac sodium
- CAS No.
- 15307-79-6
- Chemical Name
- Diclofenac sodium
- Synonyms
- Naclof;Voldal;KROPLEX;Diacron;gp45840;kriplex;ortofen;VALETAN;BENFOFEN;Naclofen
- CBNumber
- CB5474464
- Molecular Formula
- C14H10Cl2NNaO2
- Formula Weight
- 318.13
- MOL File
- 15307-79-6.mol
Diclofenac sodium Property
- Melting point:
- 288-290°C
- Density
- 0.781 g/cm3
- storage temp.
- -20°C Freezer
- solubility
- H2O: 50 mg/mL
- pka
- 4(at 25℃)
- form
- White solid
- Water Solubility
- Soluble in water to 50mg/ml.
- Merck
- 14,3081
- Stability:
- Stable.
- InChIKey
- KPHWPUGNDIVLNH-UHFFFAOYSA-M
- CAS DataBase Reference
- 15307-79-6(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38-63
- Safety Statements
- 22-36/37-45-36-26-60-20
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- AG6330000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29224999
- Toxicity
- LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 287840
- Product name
- Diclofenac Sodium
- Packaging
- 1gm
- Price
- $44.2
- Updated
- 2020/08/18
- Product number
- Y0001635
- Product name
- Diclofenac for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Price
- $190
- Updated
- 2021/03/22
- Product number
- S0765000
- Product name
- Diclofenac sodium
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Price
- $190
- Updated
- 2021/03/22
- Product number
- 1188800
- Product name
- Diclofenac sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $366
- Updated
- 2021/03/22
- Product number
- D2508
- Product name
- Diclofenac Sodium Salt
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $63
- Updated
- 2021/03/22
Diclofenac sodium Chemical Properties,Usage,Production
Uses
Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain.
Mechanisms of action
Putative mechanisms of action of diclofenac may include inhibition of leukotriene synthesis, inhibition of phospholipase A2, modulation of free arachidonic acid levels, stimulation of adenosine triphosphate-sensitive potassium channels via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and centrally mediated and neuropathic mechanisms. Other emerging mechanisms of action may include inhibition of peroxisome proliferator activated receptor-c, reduction in plasma and synovial substance P and interleukin-6 levels, inhibition of the thromboxane-prostanoid receptor and inhibition of acid-sensing ion channels.
Clinical Application
Clinical trials have demonstrated the analgesic efficacy of diclofenac sodium in terms of relieving moderate to severe postoperative pain in patients undergoing dental surgery or minor orthopaedic surgery. Subcutaneous diclofenac sodium also effectively relieved moderate to severe neuropathic pain, related to cancer or not. Diclofenac sodium was generally well tolerated in clinical trials, with injection-site reactions among the most commonly reported adverse events.
Chemical Properties
Off-White Crystalline Solid
Originator
Voltaren,Fujisawa,Japan,1974
Uses
A nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
Uses
A nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
Uses
An inhibitor of Cox-1 and Cox-2.
Definition
ChEBI: The sodium salt of diclofenac.
Manufacturing Process
Four grams of N-chloroacetyl-N-phenyl-2,6-dichloroaniline and 4 grams of
aluminum chloride are well mixed together and heated for 2 hours at 160°C.
The melt is cooled and poured onto about 50 grams of ice while it is still
warm. The oil which separates is dissolved in 50 ml of chloroform, the
chloroform solution is washed with 10 ml of water, dried over sodium sulfate
and concentrated under 11 torr. The residue is distilled. The 1-(2,6-
dichlorophenyl)-2-indolinone melts at 126°-127°C.
A solution of 186 grams of 1-(2,6-dichlorophenyl)-2-indolinone in 660 ml of
ethanol and 660 ml of 2 N sodium hydroxide solution is refluxed for 4 hours.
The solution is then cooled and left to stand for 4 hours at 0°-5°C. The
crystals which form are filtered off and recrystallized from water. The sodium
salt of 2-(2,6-dichloroanilino)-phenylacetic acid melts at 283°-285°C. The
yield is 97% of theoretical, according to US Patent 3,558,690.
brand name
Solaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
Clinical Use
Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Veterinary Drugs and Treatments
The equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.
Diclofenac sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diclofenac sodium manufacturers
- Product
- Diclofenac sodium 15307-79-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2020-12-25
- Product
- Diclofenac sodium 15307-79-6
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-16
- Product
- Diclofenac sodium 15307-79-6
- Price
- US $1.00/Kg/Bag
- Min. Order
- 5T
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2021-04-14