REVERSE T3
Description- Product Name
- REVERSE T3
- CAS No.
- 5817-39-0
- Chemical Name
- REVERSE T3
- Synonyms
- T3;TRIIODOTHYRONINE;rT3;LIOTHYRONIN;Reverse triiodothyronine;(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid;L-T3-13C6;REVERSE T3;REVERSE T3;3,3',5'-T3
- CBNumber
- CB5221268
- Molecular Formula
- C15H12I3NO4
- Formula Weight
- 650.97
- MOL File
- 5817-39-0.mol
REVERSE T3 Property
- Melting point:
- 234-238 °C(lit.)
- Boiling point:
- 534.6±50.0 °C(Predicted)
- Density
- 2.387±0.06 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder
- pka
- 2.17±0.20(Predicted)
- color
- Pale Beige to Brown
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
- InChIKey
- HZCBWYNLGPIQRK-LBPRGKRZSA-N
- SMILES
- C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 36/37/38-20/21/22-39/23/24/25-23/24/25-11
- Safety Statements
- 36-45-36/37-16
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- RTECS
- AY6750000
- F
- 8
- HS Code
- 29379000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- T-075
- Product name
- 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution
- Purity
- 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 17598
- Product name
- 3,3',5'-Triiodo-L-thyronine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 17598
- Product name
- 3,3',5'-Triiodo-L-thyronine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- 17598
- Product name
- 3,3',5'-Triiodo-L-thyronine
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- 17598
- Product name
- 3,3',5'-Triiodo-L-thyronine
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $674
- Updated
- 2024/03/01
REVERSE T3 Chemical Properties,Usage,Production
Description
Either a derivative or precursor of thyroxine. Triiodothyronine increases themetabolic rate and oxygen consumption of animal tissues. Used in biochemical research, medicine (metabolic insufficiency).
Chemical Properties
Beige Powder
Uses
One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
Uses
Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.
Definition
ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.
Biological Activity
3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].
References
[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.
REVERSE T3 Preparation Products And Raw materials
Raw materials
Preparation Products
REVERSE T3 Suppliers
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View Lastest Price from REVERSE T3 manufacturers
- Product
- T3 (Liothyronine sodium) 5817-39-0
- Price
- US $45.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 2000kg
- Release date
- 2024-03-14
- Product
- T3 5817-39-0
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-09-11
- Product
- T3 5817-39-0
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000000tons
- Release date
- 2023-11-01